2017
DOI: 10.1016/j.biopha.2017.08.071
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Effect of two andrographolide derivatives on cellular and rodent models of non-alcoholic fatty liver disease

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Cited by 26 publications
(11 citation statements)
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“…Our results demonstrated that lipid metabolism homeostasis was disrupted after HFD administration, and AG restored this metabolic disorder to some extent. The safety and ability of AG to redress the NAFLD in wistar rats on a HFD has also been reported (38). In NAFLD pathway, IL-1, IL-6 and TNF-α are the key inflammatory factors involved in the development of steatohepatitis.…”
Section: Discussionmentioning
confidence: 91%
“…Our results demonstrated that lipid metabolism homeostasis was disrupted after HFD administration, and AG restored this metabolic disorder to some extent. The safety and ability of AG to redress the NAFLD in wistar rats on a HFD has also been reported (38). In NAFLD pathway, IL-1, IL-6 and TNF-α are the key inflammatory factors involved in the development of steatohepatitis.…”
Section: Discussionmentioning
confidence: 91%
“…Lipid accumulation in the liver is associated with ER stress, mitochondrial stress or oxidative stress and impaired autophagy, resulting in lipotoxicity [ 7 10 ]. HSPs are a family of proteins that are produced by cells in response to stressful conditions [ 11 , 12 ].…”
Section: Discussionmentioning
confidence: 99%
“…Except for cells in the control group, others were cultured in a fresh medium containing 200 mM EtOH for 48 h [ 18 ]. After cells cultured in groups, intracellular lipids were extracted according to the previously described method [ 24 ]. The contents of TG and TC in cells were determined by the kit (Jiancheng Biological Engineering Research Institute Co., Ltd.Nanjing China).…”
Section: Methodsmentioning
confidence: 99%