Effect of uric acid on hypertension progression in spontaneously hypertensive rats

Durante, Paula; Chavez, M. Colas; Pérez, Mariela; Romero, Freddy; Rivera, Fernando

doi:10.1016/j.lfs.2010.05.004

Cited by 12 publications

(10 citation statements)

References 65 publications

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“…As previously described [46], these parameters were significantly elevated in SHRs compared to WKY rats, and they were both normalized by LGF treatment. However, LGF treatment did not alter WKY plasma oxidative status, confirming our previous data on hemodynamic, cellular, cardiac and vascular effects of LGF treatment, which were observed only in the hypertensive strain [28,29].…”

Section: Discussionsupporting

confidence: 76%

Liver growth factor treatment reverses vascular and plasmatic oxidative stress in spontaneously hypertensive rats

Condezo-Hoyos

Arribas²,

Abderrahim³

et al. 2012

Journal of Hypertension

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Section: Discussionsupporting

confidence: 76%

Liver growth factor treatment reverses vascular and plasmatic oxidative stress in spontaneously hypertensive rats

Condezo-Hoyos

Arribas²,

Abderrahim³

et al. 2012

Journal of Hypertension

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“…Uric acid causes hypertension in a rat model through the activation of the renin-angiotensin system, down regulation of nitric oxide, and induction of endothelial dysfunction and vascular smooth muscle proliferation (64). Some other studies showed that SUA protects against progression of hypertension in spontaneously hypertensive rats (70). Similarly to the vascular injury, understanding of the paradox should be pointed to metabolic pathway of uric acid production through xantine oxidase (1), as well as the differences between acting of uric acid inside the cells or in the extracellular milieu (71).…”

Section: Sua and Hypertensionmentioning

confidence: 98%

Uric acid as one of the important factors in multifactorial disorders – facts and controversies

Marinković²,

2012

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With considering serum concentration of the uric acid in humans we are observing hyperuricemia and possible gout development. Many epidemiological studies have shown the relationship between the uric acid and diff erent disorders such are obesity, metabolic syndrome, hypertension and coronary artery disease. Clinicians and investigators recognized serum uric acid concentration as very important diagnostic and prognostic factor of many multifactorial disorders. This review presented few clinical conditions which are not directly related to uric acid, but the concentrations of uric acid might have a great impact in observing, monitoring, prognosis and therapy of such disorders. Uric acid is recognized as a marker of oxidative stress. Production of the uric acid includes enzyme xanthine oxidase which is involved in producing of radical-oxigen species (ROS). As by-products ROS have a signifi cant role in the increased vascular oxidative stress and might be involved in atherogenesis. Uric acid may inhibit endothelial function by inhibition of nitric oxide-function under conditions of oxidative stress. Down regulation of nitric oxide and induction of endothelial dysfunction might also be involved in pathogenesis of hypertension. The most important and well evidenced is possible predictive role of uric acid in predicting short-term outcome (mortality) in acute myocardial infarction (AMI) patients and stroke. Nephrolithiasis of uric acid origin is signifi cantly more common among patients with the metabolic syndrome and obesity. On contrary to this, uric acid also acts is an ''antioxidant'' , a free radical scavenger and a chelator of transitional metal ions which are converted to poorly reactive forms.

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“…Ofori et al (20) reported a significant relationship between serum uric acid levels and target organ damage in hypertensive patients. Durante et al (21) specified that uric acid was protective against the progression of HT. While Tsioufis et al (22) found serum uric acid level to be significantly associated with body mass index, SBP, and urine albumin excretion, they revealed no relationship with left ventricular hypertrophy.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Relationship Between Uric Acid and CRP, RDW, and MPV as Cardiovascular Risk Factors in Patients with Hypertension

Karagöz¹,

Şahin²,

Karagöz³

et al. 2016

Bezmialem Science

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Objective: Many factors that are associated with both clinical outcomes and pathogenesis of disease in cases of essential hypertension have been reported. One of these is uric acid. In this study, we aimed to investigate the relationship between serum and spot urine uric acid levels and red blood cell distribution width (RDW), mean platelet volume (MPV), and C-reactive protein (CRP) levels in patients with essential hypertension. Methods:Sixty-two patients with essential hypertension were enrolled in the study between January 01, 2013 and December 31, 2013. The presence of cardiovascular disease was assessed by echocardiography, coronary angiography, and stress test. The patients were divided into two groups according to the absence (group 1) or presence (group 2) of cardiovascular complications. Data were collected for serum and spot urine uric acid levels, serum CRP levels, MPV, and RDW and were compared between the two groups.Results: Cardiovascular complications were determined in 23 patients (37.1%). In groups 1 and 2, the CRP level was 4.89 and 3.64, RDW was 13.8 and 13.5, serum uric acid level was 5.57±1.23 and 5.33±0.8, spot urine uric acid level was 65.13±29.11 and 61.94±18.13, and MPV was 7.7 and 7.2, respectively. A significant difference was not found between the two groups in terms of serum and spot urine uric acid levels, serum CRP levels, MPV, and RDW (p>0.05). In group 2, there was a significant negative correlation between the glomerular filtration rate and RDW and between RDW and MPV and positive correlation between CRP levels and RDW (p<0.01, p <0.05, and p<0.05, respectively).Conclusions: Serum and spot urine uric acid levels, serum CRP levels, MPV, and RDW cannot predict the development of cardiovascular disease in patients with essential hypertension.

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Effect of uric acid on hypertension progression in spontaneously hypertensive rats

Cited by 12 publications

References 65 publications

Liver growth factor treatment reverses vascular and plasmatic oxidative stress in spontaneously hypertensive rats

Liver growth factor treatment reverses vascular and plasmatic oxidative stress in spontaneously hypertensive rats

Uric acid as one of the important factors in multifactorial disorders – facts and controversies

Evaluation of Relationship Between Uric Acid and CRP, RDW, and MPV as Cardiovascular Risk Factors in Patients with Hypertension

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