2012
DOI: 10.1016/j.fct.2012.07.067
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Effect of ursolic acid on cardiac marker enzymes, lipid profile and macroscopic enzyme mapping assay in isoproterenol-induced myocardial ischemic rats

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Cited by 55 publications
(44 citation statements)
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“…ISO is a well-known cardiotoxic agent due to its ability to destroy myocardial cells [13,15,35,36]. Thus, studies on ISO-induced myocardial injury have provided a good insight into this pathology, which helps to evaluate the protective effect and underlying mechanism of GdCl 3 against cell damage.…”
Section: Discussionmentioning
confidence: 99%
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“…ISO is a well-known cardiotoxic agent due to its ability to destroy myocardial cells [13,15,35,36]. Thus, studies on ISO-induced myocardial injury have provided a good insight into this pathology, which helps to evaluate the protective effect and underlying mechanism of GdCl 3 against cell damage.…”
Section: Discussionmentioning
confidence: 99%
“…Isoproterenol (ISO), a b-adrenergic agonist, is reported to cause severe stress in the myocardium, giving rise to infarct-like necrosis of heart [12][13][14][15]. Two consecutive large doses of ISO lead to an increase in Ca 2?…”
Section: Introductionmentioning
confidence: 99%
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“…The animals were considered diabetic if their blood glucose level was higher than 200 mg/dL [9] . Cardiac injury was confirmed by measuring the creatine-kinase MB (CK-MB) serum level [10] 24 hours following STZ injection [11] in the Biochemistry Department, Faculty of Medicine, Cairo University. The rats were left for 8 weeks without therapy.…”
Section: Experimental Designmentioning
confidence: 99%
“…Oxidative corrosion of membrane polyunsaturated fatty acids by these free radicals within the myocardium is associated with increased levels of thiobarbituric acid reactive substances (TBARS), lipid radicals (L); lipid peroxy radical (LOO) and lipid hydroperoxides (LOOH) as observed during the initial stages of MI influenced by oxidative stress. 6 Eriodictyol is 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-2,3-dihydro-4H-chromen-4-one (Figure 1) is a flavanone extracted from Yerba Santa (Eriodictyon californicum) 7 and the twigs of Millettia duchesnei. 8 Eriodictyol present in lemon fruit, is found to suppress oxidative stress in serum, liver, and kidney of diabetic rats in combination with hesperidin.…”
Section: Introductionmentioning
confidence: 99%