An Evaluation of Antioxidant Potential of Flavonoid Eriodictyol in Isoproterenol-Induced Myocardial Infarction in Rats

Abstract

Aim:The study was designed to evaluate the antioxidant potential of eriodictyol on lipid peroxidation caused due to isoproterenol induced myocardial infarction in albino male wistar rats. Methods: Myocardial Infarction was induced by subcutaneous injection of isoproterenol, 85 mg/Kg body weight after a pretreatment period of 45 days with eriodictyol in various doses 50 mg, 100 mg and 200 mg per Kg body weight through intragastric intubation. The standard drug metoprolol succinate was administered orally at a dose of 2.5 mg per Kg body weight for 45 days followed by ISO induced myocardial infarction. Results: The study showed significant increase in the levels of thiobarbituric acid reactive substances, lipid hydroperoxides and conjugated dienes both in plasma and heart tissue with considerable decrease in the levels of enzymatic and non-enzymatic antioxidants in ISO induced myocardial infracted rats. The oral administration of eriodictyol showed significant decrease in lipid peroxidation products and with significant increase in the levels of antioxidants. The cardio protective role of eriodictyol was further assessed by histopathological studies. Conclusion: The results indicate that the oral administration of metoprolol succinate also modulates the lipid peroxidation and the antioxidant status in the ISO induced myocardial infracted rats.

The Antioxidant Enzymatic Activity of Date Palm Seedlings Under Abiotic Drought Stress

“…This result is consistent with that of Huseynova 19 and El Rabey et al 5 on wheat and Kar and Mishra. 20,21,22 on rice. This result also agrees with that of Wang 23 who noticed the increase in the antioxidant enzyme activity during germination of alfalfa under salt and drought stresses subjected to drought stress.…”

Isolation and Identification of Flavanone Derivative Eriodictyol from the Methanol Extract of Afzelia africana Bark and Its Antimicrobial and Antioxidant Activities

“…In other studies, eriodictyol was identifed as a novel insulin secretagogue through the stimulation of the cAMP/PKA signaling pathway at higher glucose concentration and hence could be applied as prophylaxis for treating drug-induced hypoglycemia [52]. Moreover, the anti-infammatory, antioxidant, antimicrobial, immunomodulatory, cytoprotective efects on the kidney, hepatoprotective, neuroprotective, analgesic, antipyretic, anticancer, and antiallergenic were well documented [41,[51][52][53][54][55][56][57]. Tese numerous pharmacological activities reported for the plant could contribute to the vast medicinal potentials reported for A. africana.…”

Pharmacological Activity of Eriodictyol: The Major Natural Polyphenolic Flavanone

“…The extracts rich in flavonoid can chelate metal particles and free radicals and associate with the metabolic products to provide a vital protection against various cellular degradation processes [ 32 ]. A recent study unleashed how ER diminishes lipid peroxidation in isoproterenol-induced myocardial infarcted rodents after 45 days of exposure to the drug [ 33 ]. ER provides increased cell protection by enhanced antioxidant activity.…”