Pharmacological Activity of Eriodictyol: The Major Natural Polyphenolic Flavanone

Deng, Zirong; Hassan, Sabba; Rafiq, Muhammad; Li, Hongshui; He, Yang; Cai, Yi; Xi, Kang; Liu, Zhaoguo; Yan, Tingdong

doi:10.1155/2020/6681352

Cited by 54 publications

(31 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Eriodictyol is a hydroxylated flavonoid compound widely present in citrus fruits, vegetables, and many medicinal plants [ 1 ]. This plant-based natural product has antioxidative, anti-inflammatory and neuroprotective effects, and can thus be potentially used in pharmaceutical, nutraceutical, or food industries [ 1 – 3 ]. At present, the main way of obtaining eriodictyol is via extraction from plants or chemical synthesis [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis of eriodictyol from tyrosine by Corynebacterium glutamicum

Liu

Liú

et al. 2022

Microb Cell Fact

View full text Add to dashboard Cite

Background Eriodictyol is a bioactive flavonoid compound that shows potential applications in medicine development and food processing. Microbial synthesis of eriodictyol has been attracting increasing attention due to several benefits. In this study, we employed a GRAS strain Corynebacterium glutamicum as the host to produce eriodictyol directly from tyrosine. Results We firstly optimized the biosynthetic module of naringenin, the upstream intermediate for eriodictyol production, through screening of different gene orthologues. Next, to improve the level of the precursor malonyl-CoA necessary for naringenin production, we introduced matB and matC from Rhizobium trifolii into C. glutamicum to convert extracellular malonate to intracellular malonyl-CoA. This combinatorial engineering resulted in around 35-fold increase in naringenin production from tyrosine compared to the initial recombinant C. glutamicum. Subsequently, the hpaBC genes from E. coli encoding 4-hydroxyphenylacetate 3-hydroxylase were expressed in C. glutamicum to synthesize eriodictyol from naringenin. Further optimization of the biotransformation process parameters led to the production of 14.10 mg/L eriodictyol. Conclusions The biosynthesis of the ortho-hydroxylated flavonoid eriodictyol in C. glutamicum was achieved for the first time via functional expression of E. coli hpaBC, providing a baseline strain for biosynthesis of other complex flavonoids. Our study demonstrates the potential application of C. glutamicum as a host microbe for the biosynthesis of value-added natural compounds from tyrosine.

show abstract

Section: Introductionmentioning

confidence: 99%

Biosynthesis of eriodictyol from tyrosine by Corynebacterium glutamicum

Liu

Liú

et al. 2022

Microb Cell Fact

View full text Add to dashboard Cite

show abstract

“…Natural molecules isolated from plants may be promising alternatives to synthetic chemicals for the management of periodontal disease [ 20 , 21 ]. Eriodictyol { Figure 1 ; [(S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-2,3-dihydrochromen-4-one]} is a flavonoid belonging to the flavanone subclass and is mainly found in the traditional medicinal plant yerba santa ( Eriodictyon californicum ) as well as in citrus fruits and vegetables [ 22 , 23 ]. Studies carried out over the past decade have shown that eriodictyol exibits a number of therapeutic properties, including antioxidant and anti-inflammatory effects [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

“…Eriodictyol { Figure 1 ; [(S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-2,3-dihydrochromen-4-one]} is a flavonoid belonging to the flavanone subclass and is mainly found in the traditional medicinal plant yerba santa ( Eriodictyon californicum ) as well as in citrus fruits and vegetables [ 22 , 23 ]. Studies carried out over the past decade have shown that eriodictyol exibits a number of therapeutic properties, including antioxidant and anti-inflammatory effects [ 22 , 23 ]. The therapeutic properties of eriodictyol appear to depend on its capacity to modulate several cell signaling pathways [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

“…Studies carried out over the past decade have shown that eriodictyol exibits a number of therapeutic properties, including antioxidant and anti-inflammatory effects [ 22 , 23 ]. The therapeutic properties of eriodictyol appear to depend on its capacity to modulate several cell signaling pathways [ 22 , 23 ]. Although a recent study showed that food supplementation with eriodictyol could prevent periodontal disease in a mouse model [ 24 ], to the best of our knowledge, there are no reports in the literature that have addressed the exact underlying mechanisms of the potential beneficial effect of eriodictyol on periodontitis.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Eriodictyol Suppresses Porphyromonas gingivalis-Induced Reactive Oxygen Species Production by Gingival Keratinocytes and the Inflammatory Response of Macrophages

Maquera-Huacho

Spolidorio

Manthey

et al. 2022

Front. Oral. Health

View full text Add to dashboard Cite

Porphyromonas gingivalis is a key pathogen of periodontitis, an inflammatory disease that affects the tooth-supporting tissues. The aim of the present study was to investigate the effects of the flavanone eriodictyol on P. gingivalis-induced reactive oxygen species (ROS) production by gingival keratinocytes and the inflammatory response of macrophages. Porphyromonas gingivalis and H2O2 acted synergistically to induce ROS production by keratinocytes. The presence of eriodictyol significantly attenuated ROS production in a dose-dependent manner. We used a macrophage model to show that eriodictyol decreases the secretion of IL-1β, IL-6, IL-8, and TNF-α induced by P. gingivalis. Evidence has been brought that this anti-inflammatory property of eriodictyol may be related to its ability to prevent the activation of the NF-κB signaling pathway by P. gingivalis. This periodontal pathogen was also found to be a potent inducer of matrix metalloproteinase (MMP) production by macrophages, including MMP-2, MMP-8, and MMP-9. Eriodictyol dose-dependently inhibited the production of all three MMPs. Lastly, eriodictyol inhibited the catalytic activity of both MMP-9 and P. gingivalis collagenase. In conclusion, eriodictyol may be a potential therapeutic agent for preventing and/or treating periodontal disease due to its antioxidant, anti-inflammatory, and anti-proteinase properties.

show abstract

“…Eriodictyol (ED) [IUPAC name (2S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-2,3-dihydrochromen-4-one], is a avonoid in the avanones subclass abundantly found in various medicinal plants, citrus fruits, and vegetables (Islam et al 2020). ED has multiple therapeutic effects such as anti-oxidant, anti-cancer, antiammatory, and neuro-protective bioactivity (Clavin et al 2007; Deng et al 2020;Islam et al 2020;Lv et al 2021). Such numerous pharmacological and biological roles of ED have attracted much research interest for increasing titer and quality (Marin et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Bioproduction of Eriodictyol By Escherichia Coli Engineered Co-Culture

Nguyen

Tatipamula

Viet

et al. 2021

Preprint

View full text Add to dashboard Cite

Eriodictyol is a flavonoid in the flavanones subclass. It is abundantly present in a wide range of medicinal plants, citrus fruits, and vegetables. In addition, eriodictyol owns numerous importantly medicinal bioactivities such as inhibition of proliferation, metastasis and induction of apoptosis in glioma cells or inhibition of glioblastoma migration, and invasion. This study described the heterologous production of eriodictyol by E. coli based co-culture engineering system from the initial substrate as D-glucose. Notably, the upstream module was composed of genes for synthesis of p-coumaric acid (pCA) from D-glucose. The downstream module consisted of genes for the synthesis of eriodictyol from p-coumaric acid. The maximal result of eryodictyol was achieved 51.5 mg/L using optimal culture conditions, while mono-culture was only achieved 21.3 mg/L. In conclusion, co-culture was the efficiently alternative approach for the synthesis of eriodictyol and other natural products.

show abstract

Pharmacological Activity of Eriodictyol: The Major Natural Polyphenolic Flavanone

Cited by 54 publications

References 94 publications

Biosynthesis of eriodictyol from tyrosine by Corynebacterium glutamicum

Biosynthesis of eriodictyol from tyrosine by Corynebacterium glutamicum

Eriodictyol Suppresses Porphyromonas gingivalis-Induced Reactive Oxygen Species Production by Gingival Keratinocytes and the Inflammatory Response of Macrophages

Bioproduction of Eriodictyol By Escherichia Coli Engineered Co-Culture

Contact Info

Product

Resources

About