Effect of vaginal sildenafil on the outcome of in vitro fertilization (IVF) after multiple IVF failures attributed to poor endometrial development

Sher, Geoffrey; Fisch, Jeffrey D

doi:10.1016/s0015-0282(02)03375-7

Cited by 223 publications

(142 citation statements)

References 11 publications

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“…Vaginal sildenafil has been shown to have favorable effects on endometrial thickening as it is observed in previous studies [12,13]. In this study, we showed that using vaginal sildenafil during the IVF cycle does improve endometrial thickness, although there have been contraindicating results in other studies too.…”

Section: Discussionsupporting

confidence: 68%

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Effect of Vaginal Sildenafil on in Vitro Fertilization Success Rates in Women With Previous Failed in Vitro Fertilization Attempts

Tehraninejad

Khazei

Ayati

et al. 2018

Asian J Pharm Clin Res

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Objectives: Endometrial thickness of <9 mm is a predictor of in vitro fertilization (IVF) failure, although neither pregnancy rates nor the pregnancy outcomes are dependent on the endometrial thickness alone. The impact that uterine artery blood flow has on endometrial growth is dependent on nitric oxide which concentrations could be altered by halting a cyclic guanosine monophosphate-mediated pathway with a phosphodiesterase type 5 selective inhibitor such as sildenafil. Methods:In this clinical trial, 72 patients aged below 45 years which have had at least two earlier failed IVF attempts were randomly split into two groups each consisting of 36 patients. Both groups were started on a long IVF protocol. The case group was also administered 100 mg vaginal sildenafil suppositories daily, starting on day 3 of menstruation which was continued until human chorionic gonadotropin administration. Endometrial thickness was measured using ultrasonography in both groups plus pregnancy rates were assessed in both groups.

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Section: Discussionsupporting

confidence: 68%

“…In a retrospective cohort analysis of 105 infertile women aged <40 years, with at least two consecutive prior IVF failures attributed to inadequate endometrial development Sher et al expressed that sildenafil citrate could enhance the endometrium development although they did not clearly evaluate the difference in the pregnancy rates [13].…”

Section: Discussionmentioning

confidence: 99%

Effect of Vaginal Sildenafil on in Vitro Fertilization Success Rates in Women With Previous Failed in Vitro Fertilization Attempts

Tehraninejad

Khazei

Ayati

et al. 2018

Asian J Pharm Clin Res

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“…Sin embargo, dada la incorporación de nuevas modalidades de tratamiento para la hipertensión pulmonar, tales como prostaciclinas, heparinas, oxido nítrico, L-arginina y sildenafil, la mortalidad materna se redujo en 30%, siendo las principales causas el ingreso tardío a control obstétrico y diagnóstico de hipertensión pulmonar después de las 25 semanas de gestación (4). Prostaciclina (PGI2) en infusión o en aerosol y la inhalación de óxido nítrico se han descrito como tratamientos efectivos de la hipertensión pulmonar (13,14), y han sido utilizados con éxito en la gestación asociada a hipertensión pulmonar primaria (14)(15)(16)(17)(18)(19). Más recientemente, ha aparecido las primeras comunicaciones sobre casos aislados, beneficiados por una intervención dirigida a aumentar la disponibilidad de guanosina monofosfato cíclica (cGMP), el mensajero intracelular de NO, mediante el inhibidor de fosfodiesterasa sildenafil (20)(21)(22)(23)(24); este ha sido empleado como droga única (22,23) o en asociación a NO inhalado (24).…”

Section: Discussionunclassified

Síndrome De Eisenmenger Y Embarazo

et al. 2007

Rev. chil. obstet. ginecol.

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INTRODUCCIÓNEl desarrollo de hipertensión pulmonar (HP) secundaria a cardiopatías congénitas con defectos septales, habitualmente ocurren en la cuarta déca-da de la vida (1). Sin embargo, hay numerosas publicaciones de mujeres embarazadas con este síndrome (2-4). Corresponde a una cardiopatía congénita del tipo de la comunicación interauricular (CIA), interventricular (CIV) y ductus persistente en las que se ha producido inversión del shunt de izquierda a derecha, lo que da como resultado un incremento progresivo de la resistencia vascular pulmonar, falla ventricular derecha y muerte (5).En embarazos normales el gasto cardíaco se incrementa entre un 30-50%, la volemia en un 40%, y el consumo de oxígeno en un 20%, modificaciones fisiológicas a las cuales el corazón sano se adapta. La función sistólica izquierda decrece en el último período del embarazo, y durante el parto las contracciones uterinas inducen una elevación adicional del gasto cardíaco de 40% aproximadamente (6). Todos estos cambios fisiológicos hacen que la hipertensión pulmonar sea pobremente tole- RESUMENAntecedentes: El embarazo está contraindicado en toda paciente con hipertensión pulmonar, y particularmente en aquellas con síndrome de Eisenmenger. Objetivo: Describir 3 casos de embarazadas con síndrome de Eisenmenger, tratadas con sildenafil. Resultados: El desarrollo del embarazo se complicó en las tres pacientes con parto prematuro, a las 30, 28 y 35 semanas, respectivamente. En 2 pacientes el parto se resolvió mediante operación cesárea. No hubo mortalidad materna ni perinatal. Conclusión: El síndrome de Eisenmenger es de alto riesgo de morbimortalidad materno-perinatal y el manejo multidisciplinario optimiza los resultados. Se describe el uso de sildenafil.PALABRAS CLAVE: Síndrome de Eisenmenger y embarazo, sildenafil SUMMARY Background: Pregnancy in contraindicated in patient with pulmonary hypertension, especially in dose with Eisenmenger syndrome. Objective: To present 3 cases of pregnancy in patients with Eisenmenger syndrome treated with sildenafil. Results: The pregnancy becomes complicated in the 3 cases, with premature delivery at 30, 28 and 35 weeks respectively. Cesarean delivery was performed in two cases. There was no maternal or perinatal mortality. Conclusion: The Eisenmenger syndrome is a high risk condition of maternal-perinatal morbimortality and the multidisciplinary handling optimizes the results. The sildenafil use is described.

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“…Treatment with high dose oral estrogen or vaginal estradiol application, intended to increase the estradiol level in the serum, as well as in the vicinity of the endometrium, has demonstrated only marginal success [22,107]. Similarly, treatment with low dose aspirin [114] or vaginal sildenafil [90], which presumably increases blood flow to the uterus, consequently improving the response to estradiol, were rather disappointing [86]. Our approach is to freeze embryos when a thin endometrium is noticed, and to transfer them in a natural cycle, if possible; or alternatively, in an artificial cycle, while applying increased dosages of estradiol, for as long as three weeks before progesterone is added.…”

Section: The Endometriummentioning

confidence: 99%

Assessment and treatment of repeated implantation failure (RIF)

Simon

Laufer

2012

J Assist Reprod Genet

215

161

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Repeated implantation failure (RIF) is determined when embryos of good quality fail to implant following several in vitro fertilization (IVF) treatment cycles. Implantation failure is related to either maternal factors or embryonic causes. Maternal factors include uterine anatomic abnormalities, thrombophilia, non-receptive endometrium and immunological factors. Failure of implantation due to embryonic causes is associated with either genetic abnormalities or other factors intrinsic to the embryo that impair its ability to develop in utero, to hatch and to implant. New methods of time-lapse imaging of embryos and assessment of their metabolic functions may improve selection of embryos for transfer, and subsequent outcomes for IVF patients, as well as for those diagnosed with RIF. This review discusses the various causes associated with RIF and addresses appropriate treatments.

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Effect of vaginal sildenafil on the outcome of in vitro fertilization (IVF) after multiple IVF failures attributed to poor endometrial development

Cited by 223 publications

References 11 publications

Effect of Vaginal Sildenafil on in Vitro Fertilization Success Rates in Women With Previous Failed in Vitro Fertilization Attempts

Effect of Vaginal Sildenafil on in Vitro Fertilization Success Rates in Women With Previous Failed in Vitro Fertilization Attempts

Síndrome De Eisenmenger Y Embarazo

Assessment and treatment of repeated implantation failure (RIF)

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