Effect of vagotomy on gastric acid secretion stimulated by pentagastrin and histamine.

Payne, Robert A.; Cox, Alan G.; Spencer, J; Cheng, F C

doi:10.1136/bmj.4.5577.456

Cited by 18 publications

(4 citation statements)

References 8 publications

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“…Historically, the acid secreting [3][4][5][6] capacity of the stomach has been used as a surrogate for vagal function, by quantifying acid secretion in response to vagal stimulation, or by spraying Congo red onto the gastric mucosa. 7 These methods are invasive and require either endoscopy or intubation of the stomach.…”

Section: Resultsmentioning

confidence: 99%

A Safe and Noninvasive Test for Vagal Integrity Revisited

et al. 2002

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Section: Resultsmentioning

confidence: 99%

A Safe and Noninvasive Test for Vagal Integrity Revisited

et al. 2002

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“…In view of a possible significant influence of atrophic mucosal changes upon gastric secretory function, the same trial was repeated after dis- Although Konturek et al5,6 reported a higher stimulatory effect of pentapeptide than that of histamine in man, the conclusion has not yet been generally accepted.7,8 The same situation was found in the vagotomized concerning the stimulatory effect of these substances on gastric secretion. Jepson and Johnston9 found almost the same stimulatory effect with pentagastrin and betazole hydrochloride in vagotomized patients with duodenal ulcer and supported the view of Payne et al 10 However, Konturek6 reported a higher stimulatory effect of histamine than that of pentagastrin in the vagotomized, while others obtained the reverse findings.11,12 In the present investigation, the individual data in the male of 20 to 49 years of age, who had not been vagotomized, disclosed a significantly higher response to AOC-tetrapeptide than to betazole hydrochloride, while composite data in the same group did not. These results are attributed to the difficulty in such a comparison in man, on account of insufficient reproducibility of gastric analysis.…”

Section: ) Reproducibility Of Secretory Response To Aoc-tetrapeptidementioning

confidence: 53%

Gastric Secretion Stimulated by Gastrin-like AOC-tetrapeptide

Yamagata

Masuda

Ishimori

et al. 1970

Tohoku J. Exp. Med.

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“…and that if the doses are increased higher acid tflow reaches outputs can be obtained, even approaching the greater curve preoperative levels. Payne et al (1967) found that the parietal cell acid Study (1967) gave a similar figure (67 %). This suggests that the effect of vagotomy on the parietal cells is constant and that the variable change in postoperative output in this series is more likely to be due to variation in the antral release of gastrin.…”

Section: Recording Of Resultsmentioning

confidence: 75%

Effect of vagotomy on the gastric secretion of acid chloride and pepsin in response to an antral stimulus and to insulin and maximal histamine stimulation.

Tovey¹,

Swaminathan²,

Parker³

et al. 1968

Gut

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In this investigation the secretory response of the stomach to an antral stimulus followed by insulin and then histamine stimulation before and after vagotomy has been estimated in order to determine: (1) the effect of vagotomy on 'endogenous' gastric secretion resulting from antral stimulation compared with its effect on 'exogenous' secretion following insulin and histamine injections; (2) the effect of vagotomy on pepsin secretion compared with its effect on acid secretion; (3) the effect of vagotomy on total chloride secretion; and (4) whether after selective vagotomy any vagal innervation may reach the stomach via the coeliac plexus and greater curve resulting in a greater response to stimuli than that obtained after total vagotomy. METHODIt was not possible to use a continuous aspiration technique because, in order to determine the antral response, it was necessary that the antrum should be stimulated by a constant amount of the stimulating fluid for a constant time. Instead the dye dilution technique, as described by Brooks, Erskine, Gephart, Swaim, and Moore (1950), was used. At the beginning of every 10 minutes 100 ml of fluid containing phenol red (7 mg/l.) was injected into the stomach and the stomach was completely emptied by aspiration at the end of the 10-minute period. From the concentration of the dye in the aspirate it was possible to calculate both the volume of juice secreted and also the amount that had emptied from the stomach. It was then possible to calculate the actual concentration and quantity of acid, chloride, and pepsin that had been secreted during the period.Both sodium bicarbonate and peptone were used as antral stimulants because there is evidence that these act on the antral mucosa in different ways (Celestin, 1966). The effect of peptone is abolished by Lignocaine solution 3 % whereas the effect of sodium bicarbonate is unaltered, suggesting that peptone acts through neuroreceptors and sodium bicarbonate acts directly on the mucosal cells.

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Effect of vagotomy on gastric acid secretion stimulated by pentagastrin and histamine.

Cited by 18 publications

References 8 publications

A Safe and Noninvasive Test for Vagal Integrity Revisited

A Safe and Noninvasive Test for Vagal Integrity Revisited

Gastric Secretion Stimulated by Gastrin-like AOC-tetrapeptide

Effect of vagotomy on the gastric secretion of acid chloride and pepsin in response to an antral stimulus and to insulin and maximal histamine stimulation.

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