Effect of Vagotomy on Gastric Secretion and Emptying Time in Dogs

Antia, F. P.; Rosiere, C. E.; Robertson, Charlotte; Grossman, M. I.

doi:10.1152/ajplegacy.1951.166.2.470

Cited by 37 publications

(10 citation statements)

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“…The response to 2-deoxy-D-glucose and to pentagastrin in the present series was similar as in experiments by other authors [2,6,10] while basal acid secretion was relatively high [1,5]. It should be noted, however, that in this series no particular care was taken to train the dogs before experiments were started.…”

Section: Discussionsupporting

confidence: 90%

Esophageal and duodenal approach for testing duodenogastric reflux in dogs

et al. 1982

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A modified Komarov-Marks esophagostomy is described. It was the aim of our experiments to show that this procedure does not harm the vagal innervation of the stomach. The vagal function was assessed by testing (1) basal secretion, (2) 2-deoxy-D-glucose-stimulated secretion, (3) pentagastrin-stimulated secretion, and (4) serum gastrin levels in five mongrel dogs. Each test was performed at least three times in each dog before and after the esophagostomy procedure, respectively. The secretion rates were not affected by surgery. It is concluded that cervical esophagostomy in dogs does not affect vagal stimulation of gastric acid secretion. For the application of tracer substances into the duodenum, two types of conduits are described: (1) a short jejunal segment and (2) a jejunal segment with an invagination valve. The pros and cons of these procedures are discussed.

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Section: Discussionsupporting

confidence: 90%

Esophageal and duodenal approach for testing duodenogastric reflux in dogs

et al. 1982

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“…The vagal nerve has stimulatory and inhibitory actions on acid secretion [20,21] and it releases several neurotransmitters, such as acetylcholine [22], gastrin-releasing peptide (GRP) [23], substance P [24], calcitonin gene-related peptide [24], and pituitary adenylate cyclase activating peptide (PACAP) [25]. Among these, GRP has a stimulatory action on gastrin release from G cells [26].…”

Section: Discussionmentioning

confidence: 99%

Histamine Mediates the Stimulatory Action of Ghrelin on Acid Secretion in Rat Stomach

Yakabi

Onouhi

et al. 2006

Dig Dis Sci

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Ghrelin, a novel growth hormone-releasing peptide, is present in the rat and human stomach and is known to stimulate acid secretion and stomach motility. However, the mechanism of action of ghrelin is not fully understood. In the present study, we attempted to elucidate the role of histamine in ghrelin-induced acid secretion in rat stomach. Intravenous administration of ghrelin at 0.8 to 20 microg/kg dose dependently increased gastric acid secretion, as measured by the gastric lumen perfusion method. The maximum response was almost equal to that of gastrin (20 microg/kg). These actions were abolished by bilateral subdiaphragmatic vagotomy. Famotidine (0.33 mg/kg) also completely inhibited the effects of ghrelin. Furthermore, ghrelin increased histidine decarboxylase (HDC) messenger RNA (mRNA) levels, as measured by real-time reverse transcription-polymerase chain reaction using LightCycler. The action of ghrelin on HDC mRNA was abolished by vagotomy. Ghrelin did not affect histamine release from isolated vascularly perfused rat stomach. Taken together, these results suggest that ghrelin stimulates gastric acid secretion via a mechanism involving activation of vagal efferent nerve and histamine release from gastric enterochromaffin-like cells.

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“…Vagal nerve has stimulatory and inhibitory actions on acid secretion [15,16] and it contains and releases several neurotransmitters such as acetylcholine [17] , gastrin-releaseing peptide (GRP) [18] , substance P [19] . Calcitonin gene-related peptide [19] and pituitary adenylate cyclase activating peptide (PACAP) [20] .…”

Section: Ghrelin and Histamine Releasementioning

confidence: 99%