Effect of Vagotomy on Postcastration Gonadotropin Secretion in Male Rats

Lg, Allen; Ca, Hodson; Hw, Burden; Ie, Lawrence

doi:10.3181/00379727-173-41695

Cited by 7 publications

(3 citation statements)

References 1 publication

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“…Previous studies have also demonstrated that levels of high-and low-density lipoproteins were normal in abdominally vagotomized rats (Ojeda et al, 1983). Ovarian function is not altered in animals subjected to reduced food intake to mimic the body weight loss induced by vagotomy (Burden and Lawrence, 1977;Allen et al, 1983). Collectively, these observations suggest that altered ovarian functions subsequent to vagotomy are not nonspecific effects attributable to weight loss.…”

Section: Av-lulo (4)supporting

confidence: 48%

The effects of vagotomy on compensatory ovarian hypertrophy and follicular activation after unilateral ovariectomy

et al. 1986

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Following unilateral ovariectomy in the rat, the remaining ovary undergoes rapid compensatory changes including an increase in the number of antral follicles (follicular activation) and an increase in ovarian weight (compensatory ovarian hypertrophy). The ovary is innervated by the vagus nerve (Burden et al., 1983). In the present study, the effects of right and left cervical vagotomy and abdominal vagotomy on follicular activation and compensatory ovarian hypertrophy in the remaining right or left ovary were compared 15 days after unilateral ovariectomy. Neither right nor left cervical vagotomy affected compensatory ovarian hypertrophy of the right or left ovaries but abdominal vagotomy depressed compensatory ovarian hypertrophy in both the right and left ovaries. Left cervical vagotomy did not inhibit follicular activation, but right cervical vagotomy prevented follicular activation in the right but not left ovary. Also, abdominal vagotomy inhibited follicular activation in the right but not the left ovary. In animals with both ovaries which were subjected to the left or right cervical vagotomy or abdominal vagotomy follicular counts in both right and left ovaries were similar. Collectively, these data indicate that the vagus nerve participates in follicular activation after unilateral ovariectomy. The data also indicate that the right ovary is more dependent on vagal influences for follicular activation than the left ovary.

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Section: Av-lulo (4)supporting

confidence: 48%

The effects of vagotomy on compensatory ovarian hypertrophy and follicular activation after unilateral ovariectomy

et al. 1986

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“…Concerning the role of the vagus nerve, bilateral vagotomy has been reported to have a transient suppressive effect on bilateral orchidectomy‐induced gonadotropin response ( 68). In adult rats, unilateral (right‐sided) transection of the vagus nerve induces a significant luteinizing hormone rise ( 69) while, in peripubertal hemicastrated rats, right‐sided vagotomy combined with right‐sided hemiorchidectomy decreases serum gonadotropin concentrations and testosterone secretion ( 70).…”

Section: Discussionmentioning

confidence: 99%

Central Nervous System Structures Labelled from the Testis Using the Transsynaptic Viral Tracing Technique

Gerendai

Tóth

Boldogkői

et al. 2000

J Neuroendocrinology

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In the present study, the transneuronal transport of neurotrophic virus technique was used to identify cell groups of the spinal cord and the brain that are transsynaptically connected with the testis. Pseudorabies virus was injected into the testis and after survival times of 3-6 days, the spinal cord and brain were processed immunocytochemically using a polyclonal antibody against the virus. Virus-infected perikarya were detected in the preganglionic neurones of the spinal cord (T10-L1, L5-S1) and in certain cell groups and areas of the brain stem, the hypothalamus and the telencephalon. In the brain stem, the cell groups and areas in which labelled neurones were present included, among others, the nucleus of the solitary tract, the caudal raphe nuclei, the locus coeruleus and the periaqueductal grey of the mesencephalon. In the hypothalamus, virus infected perikarya were observed in the paraventricular nucleus and in certain other cell groups. Telencephalic structures containing labelled neurones included the preoptic area, the bed nucleus of the stria terminalis, the central amygdala and the insular cortex. These data identify a multisynaptic circuit of neurones in the spinal cord and in the brain which may be involved in the control of testicular functions.

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“…Hypothalamic lateralization is, however, not restricted to females. Pronounced morphological differences in the central nervous system-testis axis of male rodents, and humans provide plausible hypotheses for lateralized function at the hypothalamic level [11][12][13][14]. In fact, gonadotropin-releasing hormone (GnRH) cells were found in higher numbers in the right side of the brain [15] that is consistent with the larger amount of the neurohormone produced in the right side, detectable however exclusively in the morning period [16].…”

Section: Introductionmentioning

confidence: 96%

Metabolic Lateralization in the Hypothalamus of Male Rats Related to Reproductive and Satiety States

et al. 2020

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The hypothalamus is the main regulatory center of many homeostatic processes, such as reproduction, food intake, and sleepwake behavior. Recent findings show that there is a strongly interdependent side-linked localization of hypothalamic functions between the left and right hemispheres. The goal of the present study was to trace functional asymmetry of the hypothalamus related to the regulation of food intake and reproduction, in male rodents. Subjects were examined through measurements of mitochondrial metabolism ex vivo. Impact of gonadectomy and scheduled feeding was tested on the modulation of hypothalamic metabolic asymmetry. Results show that in male rats, functional lateralization of the hypothalamus can be attributed to the satiety state rather than to reproductive control. Fasting caused left-sided metabolic dominance, while satiety was linked to the right hemisphere; trends and direction in sided dominance gradually followed the changes in satiety state. Our findings revealed satiety state-dependent metabolic differences between the two hypothalamic hemispheres. It is therefore concluded that, at least in male rats, the hypothalamic hemispheres control the satiety state-related functions in an asymmetric manner.

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Effect of Vagotomy on Postcastration Gonadotropin Secretion in Male Rats

Cited by 7 publications

References 1 publication

The effects of vagotomy on compensatory ovarian hypertrophy and follicular activation after unilateral ovariectomy

The effects of vagotomy on compensatory ovarian hypertrophy and follicular activation after unilateral ovariectomy

Central Nervous System Structures Labelled from the Testis Using the Transsynaptic Viral Tracing Technique

Metabolic Lateralization in the Hypothalamus of Male Rats Related to Reproductive and Satiety States

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