Effect of Various Anticoagulant Agents on Large‐Volume Leukocytapheresis Using New Cellsorba CS‐180S Filter

Abstract

We conducted a study to evaluate the effect of various anticoagulant agents on large-volume leukocytapheresis using the new Cellsorba CS-180S Filter filled with a changed solution of sodium pyrosulfite and sodium carbonate. We conducted the study on a total of 12 cases of rheumatoid arthritis. As the anticoagulant agents we used sodium citrate, nafamostat mesilate and low molecular weight heparin. The new Cellsorba CS-180S was safely used with the various blood anticoagulant agents. Also, through adjustment of the sodium citrate percentage to the blood flow volume, it is hypothesized that it is possible to increase the neutrophil removal rate.

Reduction in bradykinin generation during leukocytapheresis using novel cellsorbaTM CS‐180S: Effects of changing the filling solution

“…Previously, we reported the effects of changing the filling solution to sodium pyrosulfate and sodium carbonate in the novel Cellsorba TM CS-180S [11]. Regardless of the type of anticoagulant used, there was an equivalent leukocyte removal rate.…”

“…For patients who are allergic to NM, heparin-based anticoagulants such as heparin or low molecular weight heparin (LMWH), or sodium citrate-based anticoagulants have been considered. Previously, we reported the effects of changing the filling solution to sodium pyrosulfate and sodium carbonate in the novel Cellsorba TM CS-180S [11]. Regardless of the type of anticoagulant used, there was an equivalent leukocyte removal rate.…”