Effect of vinyl chloride on testis in rats

Bi, Wenfang; Wang, Youshen; Huang, Meiyuang; Meng, Deshan

doi:10.1016/0147-6513(85)90074-0

Cited by 22 publications

(7 citation statements)

References 7 publications

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“…Much previous researches estimated the application of BMD in different toxicant such as manganese, cadmium (Santamaria and Sulsky, 2010; Lei et al, 2007; Piersma et al, 2008; Suwazono et al, 2011). Previous studies also have suggested the possibility of using Benchmark analysis to assess the toxicity of VCM (Bi et al, 1985). The main advantages of the use of the BMD over NOAEL and LOAEL in our study was the more complete use of dose–response data by BMD methods not limited to being one of the experimental dose levels.…”

Section: Discussionmentioning

confidence: 99%

Estimation of benchmark dose for micronucleus occurrence in Chinese vinyl chloride-exposed workers

Wang

Tan

Xiao

et al. 2013

International Journal of Hygiene and Environmental Health

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In this study, we estimated the possibility of using benchmark dose (BMD) to assess the dose–response relationship between vinyl chloride monomer (VCM) exposure and chromosome damage. A group of 317 workers occupationally exposed to vinyl chloride monomer and 166 normal, unexposed control in Shan-dong Province northern China were examined for chromosomal damage in peripheral blood lymphocytes (PBL) using the cytokinesis-blocked micronucleus (CB-MN) assay of DNA damage. The exposed group (3.47 ± 2.65)‰ showed higher micronucleus frequency than the control (1.60 ± 1.30)‰ (P < 0.01). Occupational exposure level based on micronucleus occurrence in all individuals was analyzed with benchmark dose (BMD) methods. The benchmark dose lower limit of a one-sided 95% confidence interval (BMDL) for 10% excess risk was also determined. Results showed a dose–response relationship between cumulative exposure and MN frequency, and a BMDL of 0.54 mg/m3 and 0.23 mg/m3 for males and females, respectively. Female workers were more susceptible to MN damage than male workers.

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Section: Discussionmentioning

confidence: 99%

Estimation of benchmark dose for micronucleus occurrence in Chinese vinyl chloride-exposed workers

Wang

Tan

Xiao

et al. 2013

International Journal of Hygiene and Environmental Health

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“…With the rats killed at different time points taken together, Bi et al (1985) reported a statistically higher rate of testicular injuries in the 100-and 3000-ppm groups, but not in the 10-ppm group. There was fusion of spermatids or spermatocytes into giant cells.…”

Section: Effects On the Reproductive Systemmentioning

confidence: 97%

“…Similarly, increased liver weight by itself is not considered a significant toxic end point. So the SMACs are not derived from the discovery made by Bi et al (1985) that the liver weight increased in rats exposed to vinyl chloride at 10, 100, or 3000 ppm, 6 h/d, 6 d/w for 6 mo. Torkelson et al (1961) found that there were species differences in the sensitivity to vinyl chloride's liver toxicity.…”

Section: Liver Toxicitymentioning

confidence: 99%

Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants, Volume 1

Nasa¹

1994

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“…An acute-duration inhalation MRL was derived for vinyl chloride based on developmental effects in offspring of mice exposed during gestation (22,23). An intermediate-duration inhalation MRL was also derived based on hepatic effects in rats (24). A review of the toxicokinetic data indicated that vinyl chloride readily reaches steady state, is rapidly metabolized and excreted, and neither it nor its metabolites readily accumulate in tissue (25) (37).…”

Section: Derivation Of Health Guidance Valuesmentioning

confidence: 99%

Public Health Implications of Environmental Exposures

Rosa¹,

Pohl²,

Williams³

et al. 1998

Environmental Health Perspectives

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The Agency for Toxic Substances and Disease Registry (ATSDR) is a public health agency with responsibility for assessing the public health implications associated with uncontrolled releases of hazardous substances into the environment. The biological effects of low-level exposures are a primary concern in these assessments. One of the tools used by the agency for this purpose is the risk assessment paradigm originally outlined and described by the National Academy of Science in 1983. Because of its design and inherent concepts, risk assessment has been variously employed by a number of environmental and public health agencies and programs as a means to organize information, as a decision support tool, and as a working hypothesis for biologically based inference and extrapolation. Risk assessment has also been the subject of significant critical review. The ATSDR recognizes the utility of both the qualitative and quantitative conclusions provided by traditional risk assessment, but the agency uses such estimates only in the broader context of professional judgment, internal and external peer review, and extensive public review and comment. This multifaceted approach is consistent with the Council on Environmental Quality's description and use of risk analysis as an organizing construct based on sound biomedical and other scientific judgment in concert with risk assessment to define plausible exposure ranges of concern rather than a single numerical estimate that may convey an artificial sense of precision. In this approach biomedical opinion, host factors, mechanistic interpretation, molecular epidemiology, and actual exposure conditions are all critically important in evaluating the significance of environmental exposure to hazardous substances. As such, the ATSDR risk analysis approach is a multidimensional endeavor encompassing not only the components of risk assessment but also the principles of biomedical judgment, risk management, and risk communication. Within this framework of risk analysis, the ATSDR may rely on one or more of a number of interrelated principles and approaches to screen, organize information, set priorities, make decisions, and define future research needs and directions.Environ Health Perspect 106(Suppl 1): 369-378 (1998). http.//ehpnetl.niehs.nih.gov/docs/1998/Suppl-1/369-378derosa/ abstract.html

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Effect of vinyl chloride on testis in rats

Cited by 22 publications

References 7 publications

Estimation of benchmark dose for micronucleus occurrence in Chinese vinyl chloride-exposed workers

Estimation of benchmark dose for micronucleus occurrence in Chinese vinyl chloride-exposed workers

Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants, Volume 1

Public Health Implications of Environmental Exposures

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