Effect of viral respiratory tract infection on outcome of acute otitis media

Chonmaitree, Tasnee; Owen, Mary; Patel, Janak A.; Hedgpeth, Dawn; Horlick, David; Howie, Virgil M.

doi:10.1016/s0022-3476(05)81950-x

Cited by 166 publications

(85 citation statements)

References 19 publications

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“…Children with AOM were prospectively enrolled in clinical trials of antibiotic therapy during a 3-year period from 1990-1992 [9,10]. All children were healthy outpatients seen at our primary care clinics, and none had received antibiotics during the preceding week.…”

Section: Patientsmentioning

confidence: 99%

“…A second needle tympanocentesis and a second set of viral studies were performed at days 3-5. Venous blood was collected at study entry and follow up as described [9].…”

Section: Specimensmentioning

confidence: 99%

“…Rapid viral antigen detection was performed on both MEF and NW specimens as previously described [9]. Viral serologic tests for the same respiratory viruses were also performed by the same indirect fluorescent antibody technique; acute and convalescent sera from the same patient were tested at the same time.…”

Section: Specimen Processing and Virologic Proceduresmentioning

confidence: 99%

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Association of human metapneumovirus with acute otitis media

Williams¹,

Tollefson²,

Nair³

et al. 2006

International Journal of Pediatric Otorhinolaryngology

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SummaryObjective-Human metapneumovirus (hMPV) is a recently described paramyxovirus that has been associated with acute upper and lower respiratory infection (LRI) in infants and children worldwide. We previously observed that one-third of the children with hMPV-associated LRI had been diagnosed with a concomitant acute otitis media (AOM). In the current study, we sought to investigate an association between hMPV and children presenting with AOM as a primary diagnosis.Methods-We used realtime RT-PCR for hMPV to retrospectively test 144 paired nasal wash (NW) and middle ear fluid (MEF) specimens that had been prospectively collected from children with AOM during a 3-year period from 1990-1992. RNA was extracted from archived, frozen samples and realtime RT-PCR for hMPV was performed.Results-We detected hMPV in 8/144 (6%) NW and 1/144 MEF. Several of the children still tested positive for hMPV in NW 3 days later, showing persistent virus shedding. All were detected from November-May and six had bacterial co-pathogens. Two of the eight (25%) hMPV-infected children had no bacterial pathogen isolated, suggesting that hMPV may be associated with AOM as a sole pathogen.Conclusions-These data show that hMPV is associated with a proportion of AOM and thus has additional morbidity and healthcare impact related to these illnesses.

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Section: Patientsmentioning

confidence: 99%

“…A second needle tympanocentesis and a second set of viral studies were performed at days 3-5. Venous blood was collected at study entry and follow up as described [9].…”

Section: Specimensmentioning

confidence: 99%

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Association of human metapneumovirus with acute otitis media

Williams¹,

Tollefson²,

Nair³

et al. 2006

International Journal of Pediatric Otorhinolaryngology

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“…[13][14][15][16][17][18] There is evidence that concurrent viral and bacterial middle ear infection significantly worsens the course of AOM. 19 Influenza and its complications lead to a 10% to 30% increase in the number of antimicrobial courses prescribed to children during influenza season. 20 It now also has been shown that an antecedent influenza infection is associated with development of severe pneumococcal pneumonia in children.…”

Section: Influenza In Childrenmentioning

confidence: 99%

Technical Report: Reduction of the Influenza Burden in Children

Rennels¹,

Meissner²

2002

Pediatrics

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ABSTRACT. Epidemiologic studies have shown that children of all ages with certain chronic conditions, such as asthma, and otherwise healthy children younger than 24 months (6 through 23 months) are hospitalized for influenza and its complications at high rates similar to those experienced by the elderly. Annual influenza immunization is already recommended for all children 6 months and older with high-risk conditions. By contrast, influenza immunization has not been recommended for healthy young children. To protect children against the complications of influenza, increased efforts are needed to identify and recall high-risk children. In addition, immunization of children between 6 through 23 months of age and their close contacts is now encouraged to the extent feasible. Children younger than 6 months may be protected by immunization of their household contacts and out-of-home caregivers. The ultimate goal is universal immunization of children 6 to 24 months of age.

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“…Konvansiyonel tanısal yöntemler kullanılarak AOM'lı çocukların nazofarenksinde %30-50, orta kulak sıvısında %20 oranında solunum yolu viruslarının varlığı gösterilmiştir (12)(13)(14)(15)(16)(17). Ancak yapılan başka bir araştırmaya göre bu oranlar solunum yolu viruslarının AOM oluşuma etkisini yeterince yansıtmamaktadır.…”

Section: S Su Um MM Ma Ar Ry Y V Vi Ir Ru Us Se Es S a An Nd D A Ac Cunclassified

Viruslar ve Akut Otitis Media

Çıftçı¹,

Doğru²

2003

Ankara Üniversitesi Tıp Fakültesi Mecmuası

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Effect of viral respiratory tract infection on outcome of acute otitis media

Cited by 166 publications

References 19 publications

Association of human metapneumovirus with acute otitis media

Association of human metapneumovirus with acute otitis media

Technical Report: Reduction of the Influenza Burden in Children

Viruslar ve Akut Otitis Media

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