Effect of Vitamin C Administration on Neutrophil Apoptosis in Septic Patients After Abdominal Surgery

Ferrón-Celma, I.; Mansilla, Alfonso; Hassan, Laila; García-Navarro, Ana; Comino, Ana-Maria; Bueno, Pablo; Ferrón, Jose-Antonio

doi:10.1016/j.jss.2008.04.024

Cited by 70 publications

(86 citation statements)

References 39 publications

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“…These results are in line with previous findings of an accumulation of high vitamin C levels by neutrophils, protecting them from products released during respiratory burst in an inflammatory setting [41]. An increased number of neutrophils are observed in surgical patients, especially in those who develop sepsis [40,42]. It has been proposed that the presence of inflammatory mediators in septic patients produces an over-activation of neutrophils, which remain longer in peripheral blood circulation and exert lesional effects on tissues, thereby increasing the risk of organ failure [43].…”

Section: Vitamin C and Some Cells Of The Immune Systemsupporting

confidence: 92%

“…Whether this occurs in vitamin C-deficient organism is currently not clear, but it is interesting that extensive tissue injury is one of the major symptoms in scurvy, as main vitamin C deficiency. In a recent study, vitamin C supplementation in septic patients after abdominal surgery, for 6 consecutive days, showed the reduction in caspase-3 levels and activity, together with increased level of Bcl-2 (B-cell lymphoma 2) protein in neutrophils, suggesting the low level of apoptosis by caspase-3 and antiapoptotic effect of vitamin C in the mitochondria [40]. These results are in line with previous findings of an accumulation of high vitamin C levels by neutrophils, protecting them from products released during respiratory burst in an inflammatory setting [41].…”

Section: Vitamin C and Some Cells Of The Immune Systemmentioning

confidence: 96%

“…It has been proposed that the presence of inflammatory mediators in septic patients produces an over-activation of neutrophils, which remain longer in peripheral blood circulation and exert lesional effects on tissues, thereby increasing the risk of organ failure [43]. Consequently, the antiapoptotic effect of vitamin C on neutrophils may be detrimental to the patient by increasing their presence in circulation [40]. Stimulation of human polymorphonuclear cells with vitamin C caused a significant increase in number of latex particles phagocytized by each individual cell, whereas the number of cells capable for phagocytosis remained unchanged [44].…”

Section: Vitamin C and Some Cells Of The Immune Systemmentioning

confidence: 99%

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A short overview of vitamin C and selected cells of the immune system

Pavlović

Saraç

2010

Open Medicine

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AbstractVitamin C (ascorbic acid) is an essential water-soluble nutrient that primarily exerts its effect on a host defense mechanisms and immune homeostasis and is the most important physiological antioxidant. Stable intake of vitamin C is essential for life in humans because the body does not synthesize it. Even the numerous studies have demonstrated that vitamin C supplementation stimulates the immune system, prevents DNA damage and significantly decreases the risk of a wide range of pathologies; the potential protective mechanisms are still largely unknown. This review summarizes the recently known facts about the role of vitamin C on the selected cells of the immune system and potential molecular mechanisms involved. Further, in this review, many new data about the positive effects of vitamin C on the immune system, potential toxicological effects, vitamin C supplementation in disease development, as well as some proposed mechanisms of vitamin C activity, are discussed.

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Section: Vitamin C and Some Cells Of The Immune Systemsupporting

confidence: 92%

Section: Vitamin C and Some Cells Of The Immune Systemmentioning

confidence: 96%

Section: Vitamin C and Some Cells Of The Immune Systemmentioning

confidence: 99%

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A short overview of vitamin C and selected cells of the immune system

Pavlović

Saraç

2010

Open Medicine

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“…In addition, many reports have reported the efficacy of the water-soluble antioxidant vitamin C for treating sepsis [5,13,[28][29][30][31]. Although copper and zinc, which bind to the superoxide dismutase active center, are essential for maintaining the antioxidant system, these trace elements have not been studied clinically in septic shock patients [27].…”

Section: Discussionmentioning

confidence: 99%

Effects of the Antioxidant-Enriched Concentrated Liquid Diet ANOM on Oxidative Stress and Multiple Organ Injury in Patients with Septic Shock: A Pilot Study

Matsumoto¹,

Koga²,

Kusaka³

et al. 2011

J Anesthe Clinic Res

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Purpose: In patients with septic shock, excessive production of reactive oxygen species (ROS) by activated neutrophils injures the vascular endothelium. The body responds by recruiting systemic antioxidants, among which vitamin C most rapidly responds. Excessive and prolonged ROS production quickly depletes vitamin C, which is not synthesized by the human body. To improve the prognosis of patients with septic shock, we evaluated the ability of an antioxidant-enriched liquid diet to alleviate oxidative stress and multiple organ failure. Methods:We evaluated 15 patients with septic shock complicated by multiple organ failure who underwent treatment with ANOM ® (antioxidant-enriched concentrated liquid diet, Otsuka Pharmaceutical Co, Tokushima, Japan). Vitamin C concentration was determined by measuring serum levels of vitamin C radicals (VCR) with electron spin resonance (ESR) spectroscopy.Results: Serum VCR concentration was significantly increased from the baseline level of 0.155±0.026 after 1 day of ANOM infusion, reaching the normal range at day 3, and 0.642±0.059 at day 7. Serum 8-hydroxydeoxyguanosine (8-OHdG) concentration, a measure of ROS-induced oxidative injury, was 0.495±0.061 ng/mL at day 7, which was significantly lower than the baseline level of 0.896±0.065 ng/mL. The Sepsis-related Organ Failure Assessment (SOFA) score, a measure of multiple organ failure, decreased significantly from 10.9±1.9 at baseline to 6.2±1.7 at day 7.Conclusions: These findings show that ANOM rapidly restores vitamin C levels, suggesting that it protects against excessive oxidative stress and alleviates multiple organ failure in patients with septic shock.

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“…Treatments were administered daily on 6 consecutive postoperative days. The experimental (vitamin C) group received 450 mg/day of the vitamin in 5% dextrose administered in three equal doses, and the placebo group received an identical administration of 5% dextrose following previous studies [22,23]. Placebo-treated patients received no supplemental nutrition containing vitamins nor vitamin C.…”

Section: Treatmentsmentioning

confidence: 99%