Study of Vitamin C Administration Effect on Postoperative Plasma IL-6 Concentrations in Septic Patients After Abdominal Surgery

Ferrón-Celma, I.; Olmedo, C.; Mansilla, Alfonso; García-Navarro, Ana; Muffak, Karim; Bueno, Pablo; Ferrón, Jose-Antonio

doi:10.5772/48676

Cited by 1 publication

(2 citation statements)

References 35 publications

(45 reference statements)

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“…A D. Gutierrez et al performed a study in DM patients, and found that 500 up to 1000 mg/d vitamin C supplementation in short durations has an anti-atherosclerotic effect in diabetic patients [31]. Moreover, I Ferr on-Elma et al found that 450 mg/d vitamin C supplementation significantly can decrease plasma IL-6 concentration in patients with abdominal surgery and sepsis conditions [32]. Furthermore, Hiedra R et al administered vitamin C intravenously at a dose of 1 g every 8 h for 3 days and observed a significant decrease in inflammatory markers in COVID-19 patients [33].…”

Section: Discussionmentioning

confidence: 99%

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Vitamin C reduces interleukin-6 plasma concentration: a systematic review and meta-analysis of randomized clinical trials

Gholizadeh

Saeedy

Abdi

et al. 2021

Clinical Nutrition Open Science

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Background: Interleukin 6 is an important biomarker for distinguishing high-risk and low-risk patients, and is a constituent of the Nutrition Risk in the Critically III (NUTRIC) Score. Studies have indicated the beneficial effects of vitamin C on lowering IL-6 levels and reducing cytokine storm. However, there is still controversy about the exact effect, appropriate route, and dose of vitamin C usage. This meta-analysis was conducted to evaluate the current evidence base relating to vitamin C intervention on decreasing IL-6 levels. Methods: A systematic search was performed in PubMed, Scopus, Google Scholar, and Cochran databases, from database inception to July 3 rd 2021, to obtain any possible randomized clinical trial for inclusion. After screening and removing unrelated and duplicate articles, 24 eligible articles remained for statistical analysis. Results: We found a significant lowering effect of vitamin C supplementation on IL-6 levels via peroral (PO) (WMD ¼ -0.29 pg/l,

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Section: Discussionmentioning

confidence: 99%

“…During sepsis, plasma levels of vitamin C are notably depleted or even not measurable [21e23]. Studies have shown that vitamin C can impede the production of IL-6 [23,24], and has potent effects on diminishing inflammatory status [25,26].…”

Section: Introductionmentioning

confidence: 99%