Effect of Vitamin D deficiency in lower extremity and pulmonary venous thromboembolism

Dehghani, Khatereh; Nowrouzi, Aygin; Pourdavood, Amir Hossein; Rahmanian, Zhila

doi:10.15419/bmrat.v6i4.535

Cited by 10 publications

(14 citation statements)

References 27 publications

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“…No association between vitamin D and integrin alpha1:beta complex has been described before; however, given the large number of comparisons, then a type 1 error cannot be excluded. The data in the controls would be in accord with the studies showing that vitamin D has effects on both the thrombogenic and anti-thrombogenic variables of the coagulation system and has been associated with pulmonary embolus and deep vein thrombosis [ 11 ] and that vitamin D supplementation may be protective.…”

Section: To the Editorsupporting

confidence: 72%

Vitamin D association with coagulation factors in polycystic ovary syndrome is dependent upon body mass index

et al. 2021

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Section: To the Editorsupporting

confidence: 72%

Vitamin D association with coagulation factors in polycystic ovary syndrome is dependent upon body mass index

et al. 2021

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“…93 In the literature, there has been an interesting discussion about the probable relationship between infection-induced thrombosis and pre-existing risk factors, such as smoking, lipid levels, and possibly vitamin D status. 94 These factors can directly influence pathogen-driven thrombosis or alternatively the infection promotes the risk of thrombosis through these factors. 94 Moreover, exacerbations of CVD, including acute myocardial infarction, has been observed in some infections caused by Neisseria meningitidis, Staphylococcus aureus and recently in COVID-19 infection.…”

Section: Vitamin D and Thrombosismentioning

confidence: 99%

The Relationship Between Vitamin D and Infections Including COVID-19: Any Hopes?

Taha¹,

Abureesh²,

Alghamdi³

et al. 2021

IJGM

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Vitamin D is proposed to have a potential role in the pathogenicity, clinical presentation, prognosis, complications, and treatment of several diseases. In addition to its well-known role in calcium metabolism, vitamin D regulates both innate and adaptive immunity, and subsequently modulates the antiviral and antibacterial inflammatory immune responses. In view of the emerging coronavirus disease 2019 (COVID-19) pandemic, searching for potential therapeutic and protective strategies is of urgent interest, and vitamin D is one of the promising agents in this field. In this review, we present data from literature that supports the promising role of vitamin D in treatment and/or prevention of several infections including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This review summarizes vitamin D metabolism and its role in inflammation, thrombosis and immune regulation. It also reviews, in short, the role of vitamin D and the impact of its deficiency in several infections namely tuberculosis, influenza, human immunodeficiency virus (HIV), and SARS-CoV-2. Considering the roles of vitamin D on immune modulation, controlling of thrombosis, and attacking several microorganisms, the current review will elaborate on the association between these salient roles of vitamin D and the pathogenicity of various infectious agents including COVID-19. Consequently, the comprehensive finding of the current review shows a possible significant impact of vitamin D supplement as a hope in preventing, treating, and/or improving the progression of certain infections, specifically during the worldwide attempts to fight against the COVID-19 pandemic and minimize the severity of health complications encountered accordingly. In addition, avoiding a status of vitamin D deficiency to obtain its positive effects on the immune system and its protective mechanism during infections will be a general benefit overall.

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“…While the anti-thrombogenic components are antithrombin, plasminogen, tissue plasminogen activator, heparin, thrombomodulin, and protein C and S [53]. The anti-thrombotic effects of vitamin D on these thrombogenic and anti-thrombogenic components of the coagulation system have been very well documented [51,54,55]. A recent study demonstrated the association of low vitamin D levels with the development of deep venous thromboembolic (DVT) events in patients with ischemic stroke [51].…”

Section: Role Of Vitamin D In the Coagulation Pathwaymentioning

confidence: 99%

“…In another study, expression of eNOS was shown to be reduced by 50% in aortic tissue of VDR gene knockout when compared with the wild type mice [54]. A research paper employing an endothelial-specific knockout of the murine VDR gene showed a significant impairment in acetylcholine-induced aortic relaxation [101].…”

Section: Role Of Vitamin D In the Endothelial Cell Activationmentioning

confidence: 99%

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Emerging Role of Vitamin D and its Associated Molecules in Pathways Related to Pathogenesis of Thrombosis

2019

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Vitamin D, besides having an essential role in calcium and bone metabolism, also acts as a mediator of many non-calcemic effects through modulations of several biological responses. Vitamin D exists in its two major forms, vitamin D 2 , or commonly known as ergocalciferol, and vitamin D 3 , or commonly known as cholecalciferol. Both of these forms bind to vitamin D-binding protein to get transported to all vital target organs, where it serves as a natural ligand to vitamin D receptors for enabling their biological actions. Clinical reports corroborating vitamin D deficiency with an increase in thrombotic episodes implicate the role of vitamin D and its associated molecule in the regulation of thrombosis-related pathways. Thrombosis is the formation and propagation of a blood clot, known as thrombus. It can occur either in the arterial or the venous system resulting in many severe complications, including myocardial infarction, stroke, ischemia, and venous thromboembolism. Vitamin D, directly or indirectly, controls the expression of several genes responsible for the regulation of cellular proliferation, differentiation, apoptosis, and angiogenesis. All of these are the processes of potential relevance to thrombotic disorders. This review, thus, discussed the effects of vitamin D on pathways involved in thrombosis, such as hemostatic process, inflammatory pathway, and endothelial cell activation, with a focus on the molecular mechanisms associated with them.

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Effect of Vitamin D deficiency in lower extremity and pulmonary venous thromboembolism

Cited by 10 publications

References 27 publications

Vitamin D association with coagulation factors in polycystic ovary syndrome is dependent upon body mass index

Vitamin D association with coagulation factors in polycystic ovary syndrome is dependent upon body mass index

The Relationship Between Vitamin D and Infections Including COVID-19: Any Hopes?

Emerging Role of Vitamin D and its Associated Molecules in Pathways Related to Pathogenesis of Thrombosis

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