Effect of Vitamin D Deficiency and Replacement on Endothelial Function in Asymptomatic Subjects

Tarçın, Özlem; Yavuz, Dilek Gogas; Özben, Beste; Telli, Ahu; Öğünç, Ayliz Velioğlu; Yüksel, Meral; Toprak, Ahmet; Yazıcı, Dilek; Sancak, Seda; Deyneli, Oğuzhan; Akalın, Sema

doi:10.1210/jc.2008-1212

Cited by 365 publications

(183 citation statements)

References 38 publications

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“…Low 25(OH)D levels have been found to be associated with endothelial dysfunction, infl ammation, increased vascular stiffness and high coronary artery calcium scores [5]. In addition, 25(OH)D defi ciency aff ects vascular functions by aggravating atherosclerosis, while treatment with 25(OH)D may have protective eff ects on atherosclerosis [6,7]. Low 25(OH)D levels have been found to be associated with early signs of atherosclerosis such as increased carotid intima-media wall thickness [8].…”

Section: -Oh Vitamin D (25(oh)d)mentioning

confidence: 99%

Association between serum vitamin D levels and subclinical coronary atherosclerosis and plaque burden/composition in young adult population

Satılmış

Çelik²,

Bıyık

et al. 2015

Biomol Biomed

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Evidence suggests that low 25-OH vitamin D 25(OH)D concentrations may increase the risk of several cardiovascular diseases such as hypertension, peripheral vascular disease, diabetes mellitus, obesity, myocardial infarction, heart failure and cardiovascular mortality. Recent studies suggested a possible relationship between vitamin D defi ciency and increased carotid intima-media wall thickness and vascular calcifi cation. We hypothesized that low 25(OH)D may be associated with coronary atherosclerosis and coronary plaque burden and composition, and investigated the relationship between serum vitamin D levels and coronary atherosclerosis, plaque burden or structure, in young adult patients by using dual-source 128x2 slice coronary computed tomography angiography (CCTA). We included 98 patients with coronary atherosclerosis and 110, age and gender matched, subjects with normal fi ndings on CCTA examinations. Patients with subclinical atherosclerosis had signifi cantly higher serum total cholesterol, triglycerides, hs-CRP, uric acid, HbA1c and creatinine levels and lower serum 25(OH)D levels in comparison with controls. Th ere was no signifi cant correlation between 25(OH)D and plaque morphology. Th ere was also a positive relationship between 25(OH)D and plaque burden of coronary atherosclerosis. In multivariate analysis, coronary atherosclerosis was associated high hs-CRP (adjusted OR: 2.832), uric acid (adjusted OR: 3.671) and low 25(OH)D (adjusted OR: 0.689). Low levels of 25(OH)D were associated with coronary atherosclerosis and plaque burden, but there was no signifi cant correlation between 25(OH)D and plaque morphology.

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Section: -Oh Vitamin D (25(oh)d)mentioning

confidence: 99%

Association between serum vitamin D levels and subclinical coronary atherosclerosis and plaque burden/composition in young adult population

Satılmış

Çelik²,

Bıyık

et al. 2015

Biomol Biomed

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“…Recent clinical studies have associated low levels of 25-OH VD with hypertension, coronary artery calcification, and cardiovascular diseases such as myocardial infarction, acute stroke, congestive heart failure, and diabetes mellitus [6][7][8][9]. The mechanisms underlying the role of VD in the prevention of cardiovascular disease are not known; however, they may involve diverse physiological actions on the vascular wall, including reduction of smooth muscle cell proliferation, reduction of secretion of the pro-inflammatory cytokines interleukin-6 and tumour necrosis factor-alpha by macrophages, and increased secretion of the anti-inflammatory cytokine interleukin-10, all acting to reduce vascular inflammation [10,11]. Given its relationship with cardiovascular disease, VD insufficiency may be associated with CT.…”

Section: Discussionmentioning

confidence: 99%

“…Postulated mechanisms for these presumed cardiovascular effects include endothelial dysfunction, inflammation, reduced vessel compliance, detrimental effects via bone proteins such as osteoprotegerin, as well as dysregulation of the renin-angiotensin system and arterial wall calcification because of increased parathyroid hormone levels [10,11]. Additionally, VD effectively preserved the structure of elastic fibres and the ratio of elastic fibres to collagen fibres in the artery media [12].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D insufficiency is associated with coronary artery tortuosity

et al. 2017

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A b s t r a c tBackground: Increasing evidence suggests a relationship between vitamin D (VD) insufficiency and cardiovascular disease. Aim:We aimed to investigate the association between serum 25-hydroxyvitamin D (25-OH VD) with coronary tortuosity (CT) in patients with normal or near-normal (< 40% stenosis) coronary arteries. Methods:The present study was cross-sectional and observational. We enrolled 356 consecutive patients who had undergone coronary angiography for suspected ischaemic heart disease and were found to have normal or near-normal coronary arteries. Patients were categorised as VD insufficient (< 30 ng/mL) or VD sufficient (≥ 30 ng/dL). CT was defined as the presence of ≥ three bends (defined as ≥ 45° change in vessel direction) along the main trunk of at least one coronary artery, present both in systole and in diastole. Results:The study populations were divided into two groups according to the presence of CT: patients with CT (n = 103, 29%) and patients without CT (NCT; n = 253, 71%). CT is more frequently seen in elderly women and is positively correlated with hypertension. The incidence of VD insufficiency was significantly higher in the CT group (n = 46, 45%) than in the NCT group (n = 90, 36%; p = 0.005). In further multivariate logistic regression analyses, adjustment for major clinical parameters affecting CT showed statistically significant correlations between 25-OH VD and CT (odds ratio = 0.77, 95% confidence interval 0.66-0.98, p = 0.006). Conclusions: Vitamin D insufficiency was independently associated with coronary tortuosity.Key words: vitamin D insufficiency, coronary tortuosity, coronary artery disease, biomarkers, coronary angiography Kardiol Pol 2017; 75, 2: 174-180 INTRODUCTIONCoronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide. Coronary angiography is still the gold standard for the diagnosis of CAD, and coronary artery tortuosity (CT) is a common coronary angiography (CAG) finding [1][2][3]. The aetiology and clinical importance of CT are still unclear. CT is generally attributed to age-dependent, pathologic changes of elastic material in the vessel, and hypertension due to elongation and dilatation of the arteries with left ventricular hypertrophy [3,4]. A recent clinical trial showed that CT was associated with subclinical atherosclerosis and increased coronary artery calcification, even in the absence of significant obstructive lesion [5].

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“…Therefore, adipose tissue may have some influence on endothelial function. Tarcin et al (2009) demonstrated that vitamin D replacement increased serum leptin levels accompanied by improving FMD in asymptomatic subjects. In the present study, ELD did not change the increased body weight in OVX rats.…”

Section: Limitations Of This Studymentioning

confidence: 97%

Eldecalcitol prevents endothelial dysfunction in postmenopausal osteoporosis model rats

Serizawa¹,

Tashiro²,

Takeda

et al. 2015

Journal of Endocrinology

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Postmenopausal women have high incidence of cardiovascular events as estrogen deficiency can cause endothelial dysfunction. Vitamin D is reported to be beneficial on endothelial function, but it remains controversial whether vitamin D is effective for endothelial dysfunction under the treatment for osteoporosis in postmenopausal women. The aim of this study was to evaluate the endothelial protective effect of eldecalcitol (ELD) in ovariectomized (OVX) rats. ELD (20 ng/kg) was orally administrated five times a week for 4 weeks from 1 day after surgery. After that, flow-mediated dilation (FMD) as an indicator of endothelial function was measured by high-resolution ultrasound in the femoral artery of living rats. ELD ameliorated the reduction of FMD in OVX rats. ELD inhibited the increase in NOX4, nitrotyrosine, and p65 and the decrease in dimer/monomer ratio of nitric oxide synthase in OVX rat femoral arteries. ELD also prevented the decrease in peroxisome proliferator-activated receptor gamma (PPARg) in femoral arteries and cultured endothelial cells. Although PPARg is known to inhibit osteoblastogenesis, ELD understandably increased bone mineral density of OVX rats without increase in PPARg in bone marrow. These results suggest that ELD prevented the deterioration of endothelial function under condition of preventing bone loss in OVX rats. This endothelial protective effect of ELD might be exerted through improvement of endothelial nitric oxide synthase uncoupling, which is mediated by an antioxidative effect through normalization of vascular PPARg/NF-kB signaling.

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Effect of Vitamin D Deficiency and Replacement on Endothelial Function in Asymptomatic Subjects

Cited by 365 publications

References 38 publications

Association between serum vitamin D levels and subclinical coronary atherosclerosis and plaque burden/composition in young adult population

Association between serum vitamin D levels and subclinical coronary atherosclerosis and plaque burden/composition in young adult population

Vitamin D insufficiency is associated with coronary artery tortuosity

Eldecalcitol prevents endothelial dysfunction in postmenopausal osteoporosis model rats

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