Effect of vitamin D on gastrointestinal symptoms and health‐related quality of life in irritable bowel syndrome patients: a randomized double‐blind clinical trial

Abbasnezhad, Amir; Amani, Reza; Hajiani, Eskandar; Alavine­jad, Pezhman; Cheraghian, Bahman; Ghadiri, Ataallah

doi:10.1111/nmo.12851

Cited by 59 publications

(88 citation statements)

References 47 publications

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“…This is in accordance with other studies in elderly community‐living participants and in heart failure patients . However, other studies have reported improvement in quality of life in patients with irritable bowel syndrome as well as in patients with Crohn's disease, the latter in an uncontrolled trial …”

Section: Discussionsupporting

confidence: 92%

“…This should be highly relevant in the context of the possible pleiotropic effects of vitamin D, where quality of life could be considered a composite end‐point integrating various health effects of vitamin D. Observational studies have reported positive associations between serum 25(OH)D levels and quality of life . The results from intervention studies are, however, conflicting …”

Section: Introductionmentioning

confidence: 99%

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The effect of high‐dose vitamin D supplementation on muscular function and quality of life in postmenopausal women—A randomized controlled trial

Grimnes

Emaus

Cashman

et al. 2017

Clinical Endocrinology

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

The effect of high‐dose vitamin D supplementation on muscular function and quality of life in postmenopausal women—A randomized controlled trial

Grimnes

Emaus

Cashman

et al. 2017

Clinical Endocrinology

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“…In fact, vitamin D has been proposed as a potential treatment for IBS. 38,39 Due to the relative abundance of vitamin D responsive elements (VDREs) in hundreds of vitamin D regulated genes throughout the genome, 40 we postulated that expression of some IBS candidate biomarker genes may be influenced by the presence of the active hormonal metabolite of vitamin D, 1,25-dihydroxyvitamin D 3 (1,25D). 41 The manner in which this potential regulation occurs and the specific genes involved in IBS pathophysiology may suggest possible new approaches to treatment.…”

Section: Discussionmentioning

confidence: 99%

Gene Expression Profiling and Assessment of Vitamin D and Serotonin Pathway Variations in Patients With Irritable Bowel Syndrome

Dussik

Hockley

Grozić

et al. 2018

J Neurogastroenterol Motil

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Background/AimsIrritable bowel syndrome (IBS) is a multifaceted disorder that afflicts millions of individuals worldwide. IBS is currently diagnosed based on the presence/duration of symptoms and systematic exclusion of other conditions. A more direct manner to identify IBS is needed to reduce healthcare costs and the time required for accurate diagnosis. The overarching objective of this work is to identify gene expression-based biological signatures and biomarkers of IBS. MethodsGene transcripts from 24 tissue biopsy samples were hybridized to microarrays for gene expression profiling. A combination of multiple statistical analyses was utilized to narrow the raw microarray data to the top 200 differentially expressed genes between IBS versus control subjects. In addition, quantitative polymerase chain reaction was employed for validation of the DNA microarray data. Gene ontology/pathway enrichment analysis was performed to investigate gene expression patterns in biochemical pathways. Finally, since vitamin D has been shown to modulate serotonin production in some models, the relationship between serum vitamin D and IBS was investigated via 25-hydroxyvitamin D (25[OH]D) chemiluminescence immunoassay. ResultsA total of 858 genetic features were identified with differential expression levels between IBS and asymptomatic populations. Gene ontology enrichment analysis revealed the serotonergic pathway as most prevalent among the differentially expressed genes. Further analysis via real-time polymerase chain reaction suggested that IBS patient-derived RNA exhibited lower levels of tryptophan hydroxylase-1 expression, the enzyme that catalyzes the rate-limiting step in serotonin biosynthesis. Finally, mean values for 25(OH)D were lower in IBS patients relative to non-IBS controls. Conclusions IntroductionIrritable bowel syndrome (IBS) is one of the most common gastrointestinal (GI) disorders afflicting between 10-15% of the global population.1 Primary symptoms associated with IBS include abdominal pain and irregular bowel movements that, based upon the predominant symptom pattern, may be utilized to subdivide the syndrome into 3 classifications: diarrhea-predominant IBS (IBS-D), constipation-predominant IBS (IBS-C), and mixed IBS (IBS-M).2 However, the subtype of IBS that an individual is classified does not necessarily remain static; patients can evolve over time from diarrheic or mixed type to constipative. The chronic and erratic nature of IBS can lead to a multitude of secondary effects, such as depression, anxiety, poor quality of life, insomnia, and sexual dysfunction. 3Using the current diagnostic model for IBS, the Rome IV criteria, symptoms must be present for 3 months or longer before diagnoses can be established. 4 Other disorders with IBS-like symptoms that should be excluded include celiac disease, inflammatory bowel disease (IBD), malabsorptive disorders, pelvic floor disorders, and colon cancer. Further, once diagnosed, treatment for IBS patients may be mostly palliative in nature with dietary changes...

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“…Previous studies have shown that vitamin D deficiency is common among IBS patients [11, 36]. Indeed, as in a previous case report [10] and according to a recent randomized control trial [37] study, vitamin D supplementation has a beneficial effect on the IBS symptoms; currently vitamin D is considered to have potential benefits in the treatment of IBS [10]. …”

Section: Discussionmentioning

confidence: 68%

Serum Transaminase Concentrations and the Presence of Irritable Bowel Syndrome Are Associated with Serum 25-Hydroxy Vitamin D Concentrations in Adolescent Girls Who Are Overweight and Obese

et al. 2017

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Background/Aims: Vitamin D deficiency has become endemic globally and its etiology is complex. Few studies have investigated the determinants of serum 25-hydroxy vitamin D (25-OH D). The aim of this study was to investigate the association between lifestyle patterns, liver functional tests (LFTs), and the presence of irritable bowel syndrome (IBS) with serum 25-OH D in apparently healthy girls. Methods: This cross-sectional study was undertaken in 965 adolescent girls aged 12–18 years. IBS was diagnosed using the Rome III questionnaire. An electrochemiluminescence method was used to measure serum 25-OH D. LFTs were measured using commercial kits and an auto analyzer. Linear regression and univariate analyses were performed to determine the association between continuous and categorical variables with serum 25-OH D respectively. Results: Serum 25-OH D was significantly higher in normal weight subjects compared to either overweight or obese subjects (9.5 ± 7.02 vs. 7.9 ± 5.7 ng/mL, p = 0.03). Physical activity level was positively associated with serum 25-OH D in overweight and obese subjects (β = 0.15, p < 0.05). An inverse relationship was found between the presence of IBS and 25-OH D in both normal (β = –1.95, p < 0.05), overweight and obese subjects (β = –1.83, p < 0.05). Serum alanine transaminase (ALT; β = –0.19, p < 0.05) and aspartate transaminase (β = –0.17, p < 0.05) were inversely associated with serum 25-OH in overweight and obese subjects. Conclusions: Individuals with IBS had significantly lower serum 25-OH D concentrations. In addition, there was an inverse association between serum ALT and 25-OH D. Prospective studies, and perhaps interventional trials, will be required to clarify these associations.

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Effect of vitamin D on gastrointestinal symptoms and health‐related quality of life in irritable bowel syndrome patients: a randomized double‐blind clinical trial

Abstract: Vitamin D seems to be an effective and safe option to improve QoL and symptoms of IBS. ClinicalTrials.gov (NCT02579902).

Cited by 59 publications

References 47 publications

The effect of high‐dose vitamin D supplementation on muscular function and quality of life in postmenopausal women—A randomized controlled trial

The effect of high‐dose vitamin D supplementation on muscular function and quality of life in postmenopausal women—A randomized controlled trial

Gene Expression Profiling and Assessment of Vitamin D and Serotonin Pathway Variations in Patients With Irritable Bowel Syndrome

Serum Transaminase Concentrations and the Presence of Irritable Bowel Syndrome Are Associated with Serum 25-Hydroxy Vitamin D Concentrations in Adolescent Girls Who Are Overweight and Obese

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