Effect of vitamin D on clinical and biochemical parameters in polycystic ovary syndrome women: A meta‐analysis

Abstract

Aim: Using a meta-analysis framework, we investigated the association between the serum level of vitamin D and the risk of polycystic ovary syndrome (PCOS) and further examined the therapeutic effect of vitamin D on the clinical features of PCOS. Material and Methods: Multiple databases were searched to retrieve studies. We chose clinical studies that investigated the relation between the serum level of vitamin D and the risk of PCOS or the therapeutic effect of vitamin D on PCOS. The search results were screened according to strict inclusion and exclusion criteria to select high-quality studies for inclusion. Statistical analyses were carried out using STATA 12.0. Results: Seventeen studies were eligible in this meta-analysis. The levels of 25-hydroxyvitamin D and the quantitative insulin-sensitivity check index in the PCOS group were remarkably lower than in the controls, whereas the homeostasis model assessment of insulin resistance in the PCOS group was markedly higher than in the controls. No statistically significant difference was observed in serum parathyroid hormone levels between the two groups. The 25-hydroxyvitamin D levels were significantly elevated after PCOS patients received vitamin D 3 treatment, but serum parathyroid hormone concentration, homeostasis model assessment of insulin resistance and quantitative insulin-sensitivity check index did not show any significant changes, indicating a lack of therapeutic response. Conclusion: Our results suggest that the serum level of vitamin D is associated with the risk of PCOS, but the therapeutic effect of vitamin D on PCOS remains to be further explored.

Vitamin D and aspects of female fertility

“…[71][72][73][74][75][76][77][78][79][80][81][82][83][84] Meanwhile, recent meta-analyses of supplementation studies could not support a therapeutic effect of vitamin D treatment on metabolic disorders of the syndrome, [85][86][87] apart from its positive effect on the reduction of serum triglycerides. 88 In terms of hyperandrogenism markers, one meta-analysis con-IR.…”

Vitamin D predictors in polycystic ovary syndrome: a meta-analysis

“…Vitamin D insufficiency/deficiency is also common (10-60%) in the general adult population worldwide [2][3][4][5]. Evidence from two meta-analyses [12,13] suggests lower serum vitamin D concentrations in patients with PCOS than in controls, which are related to the metabolic and hormonal dysregulation of the syndrome. Evidence from two meta-analyses [12,13] suggests lower serum vitamin D concentrations in patients with PCOS than in controls, which are related to the metabolic and hormonal dysregulation of the syndrome.…”

Vitamin D status and premature adrenarche

“…The 25(OH)D level has been reported to be significantly low in patients with PCOS compared with controls . A meta‐analysis also suggested that serum vitamin D was associated with hyperandrogenism . Vitamin D deficiency has been shown to be related to IR both in humans and in animal models .…”