Effect of Vitamin D supplement on mood status and inflammation in Vitamin D deficient Type 2 diabetic women with anxiety: A randomized clinical trial

Introduction: Many sources list a number of properties of vitamin D on human health. It seems that the benefits of using this vitamin include not only the regulation of the calcium-phosphate metabolism, but also a number of other applications, also in human mental health. The aim of the study: The aim of the study was to research about the influence of vitamin D on the mental health. The research was done on the problems such as depression, anxiety, psychoses, stress, mood and emotions. Material and method: The literature was found using websites such as PubMed or Google Scholar was used to develop this work. Description of the state of knowledge: A number of studies have confirmed that vitamin D can have a significant impact on reducing the level of depression. One example of a study on this topic is that high vitamin D supplementation in women in early pregnancy can protect them from late depression during the last weeks of pregnancy. Likewise, adequate vitamin D supplementation in older people can improve mental health and reduce the likelihood of depression and Seasonal Mood Disorder (SAD). In addition, vitamin D can reduce the probability of psychosis or anxiety disorders. Summary: Many sources report a positive correlation between vitamin D supply and mental health. Often the differences are also noticeable, but not statistically significant. This work sometimes shows divergent views of scientists, which is important to continue research into the effects of vitamin D on mental health in humans.

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“…It also assessed the intensity of stress in the respondents' lives. However, this was not related to any degree with vitamin D levels [32].…”

Section: Stressmentioning

confidence: 69%

The effect of vitamin D on mental health – literature analysis

Kozyra¹,

Zimnicki²,

Kaczerska³

et al. 2020

J Educ Health Sport

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“…The basic details of the studies included in the systematic review [26][27][28][29][30][31] are presented in Table 2. The included studies that evaluated the influence of vitamin D supplementation on the mental health of diabetic patients were conducted mainly in Iran [29][30][31], and also in the United States of America [28], Canada [27], and the Netherlands [26]. The study sample comprised patients recruited from the specific clinics of the hospitals [27,29,31] or from general practitioners [26].…”

Section: Resultsmentioning

confidence: 99%

“…The included studies that evaluated the influence of vitamin D supplementation on the mental health of diabetic patients were conducted mainly in Iran [29][30][31], and also in the United States of America [28], Canada [27], and the Netherlands [26]. The study sample comprised patients recruited from the specific clinics of the hospitals [27,29,31] or from general practitioners [26]. Some groups were recruited to be characterized by specific diabetes complications, such as chronic kidney disease [27] or painful diabetic neuropathy [31].…”

Section: Resultsmentioning

confidence: 99%

“…Some groups were recruited to be characterized by specific diabetes complications, such as chronic kidney disease [27] or painful diabetic neuropathy [31]. Some studies included patients suffering from mental health problems, such as anxiety [29] or depressive symptomatology [28,30], while some included patients were diagnosed with vitamin D deficiency only [29,31]. The basic characteristics of the participants of the studies included in the systematic review are presented in Table 3.…”

Section: Resultsmentioning

confidence: 99%

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Influence of Vitamin D Supplementation on Mental Health in Diabetic Patients: A Systematic Review

et al. 2021

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Diabetes is associated with a number of mental health consequences, including enhanced risk of depression and anxiety, as well as decreased quality of life, and vitamin D deficiency is considered to be one of the factors that influence these outcomes in diabetic patients. The aim of the present study was to conduct a systematic review of the literature presenting the data regarding the influence of vitamin D supplementation on mental health in diabetic adults. This study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and registered in the International Prospective Register of Systematic Reviews (PROSPERO) database (Registration number CRD42020155779). A systematic search of the PubMed and Web of Science databases was performed, and the intervention studies published until September 2021 were included in the review. The human studies were included if an adult sample of diabetic individuals received vitamin D supplementation during the intervention and its effect on any mental health aspect was assessed, but studies presenting the influence of combined supplementation of multiple nutrients were excluded. After removing duplicate records, a total of 8,514 publications were screened and assessed independently by two researchers, based on their title, abstract, and full text. Finally, six studies were included in the current systematic review, and the risk of bias was evaluated using the Newcastle–Ottawa Scale (NOS). The included studies analyzed the influence of a specific dose of vitamin D, or different doses of vitamin D, or compared the results of supplementation with a specific dose of vitamin D against the placebo group. The supplementation was performed for at least 12 weeks. The mental health outcomes analyzed in these studies included health-related quality of life, depression, anxiety, stress, and general mental health status of adult diabetic patients. The results of the majority of the studies confirmed the positive influence of vitamin D supplementation on the mental health of diabetic individuals. Those studies that analyzed the influence of vitamin D supplementation on depression and anxiety established the beneficial effect of the vitamin. In some studies, the influence of vitamin D supplementation on the health-related quality of life was not considered unless combined with mindfulness training. However, it must be emphasized that different dosage regimens and intervention periods were followed in the reviewed studies, and only a small number of studies were randomized against placebo, which should be considered as a limitation of the present study. The findings of the conducted systematic review demonstrated the positive influence of vitamin D supplementation on the mental health of diabetic patients, which was proved for anxiety and depression, but in the case of health-related quality of life, the positive effect was observed only when the intervention included mindfulness training. These outcomes suggest that supplementation should be recommended to improve the vitamin D status and the mental health of patients in this group.

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“…Moreover, our results showed that people with depression, anxiety, and insomnia take significantly more vitamin D ( Table 3 and Figure 1 ). Previous interventions have shown the impact of vitamin D deficiency on depression [ 50 , 51 ], however, limited studies have been carried out to illustrate the association of anxiety disorders with serum levels of vitamin D [ 52 ]. Penckofer et al reported that six-month intervention with 50,000 IU vitamin D significantly decreased depression and anxiety in people with type 2 diabetes mellitus (T2DM) who had depression [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Dietary Intake and Mental Health among Saudi Adults during COVID-19 Lockdown

Alfawaz

Yakout

Wani

et al. 2021

IJERPH

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The study aimed to explore the influence of the COVID-19 lockdown on the mental status and dietary intake of residents in Saudi Arabia. In this cross-sectional study, an online survey was conducted from 11 May to 6 June 2020 corresponding to almost two weeks during and after Ramadan (23 April–23 May 2020). The Patient Health Questionnaire was used to assess anxiety, depression, and insomnia. Logistic regression analysis was used to identify predictors of anxiety, depression, and insomnia. The prevalence of anxiety, depression, and insomnia among the participants was 25.4%, 27.7%, and 19.6%, respectively. Participants aged ≥50 years with high income (≥8000 SAR) were at a lower risk of developing depression, whereas participants of the same age group with income 5000–7000 SAR were at high risk of developing anxiety. Students and master-educated participants suffer from median elevated depression and are required to take more multivitamins and vitamin D than others. Anxiety and depression were more common among married participants with low income. There is a wide range of Saudi residents who are at a higher risk of mental illness during the COVID-19 pandemic. Policymakers and mental healthcare providers are advised to provide continuous monitoring of the psychological consequences during this pandemic and provide mental support.

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Effect of Vitamin D supplement on mood status and inflammation in Vitamin D deficient Type 2 diabetic women with anxiety: A randomized clinical trial

Cited by 29 publications

References 52 publications

The effect of vitamin D on mental health – literature analysis

The effect of vitamin D on mental health – literature analysis

Influence of Vitamin D Supplementation on Mental Health in Diabetic Patients: A Systematic Review

Dietary Intake and Mental Health among Saudi Adults during COVID-19 Lockdown

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