Effect of vitamin D treatment in children with attention-deficit hyperactivity disorder

Dehbokri, Nadia; Noorazar, Gholamreza; Ghaffari, Aida; Mehdizadeh, Gita; Sarbakhsh, Parvin; Ghaffary, Saba

doi:10.1007/s12519-018-0209-8

Cited by 35 publications

(33 citation statements)

References 35 publications

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“…In rats, maternal vitamin D deficiency was associated with increased DAT density in the nucleus accumbens of female, but not male, offspring [ 106 ]. A study of 96 children with ADHD found that vitamin D supplementation (50 000IU/week) for eight weeks improved ADHD symptoms as assessed by the Conners Parent Rating Scale [ 107 , 108 ]. Vitamin D supplementation produced an increase in dopamine, but not serotonin, in children with ADHD [ 108 ].…”

Section: Gut Microbiota and Neurotransmitters In Autism Spectrum Disomentioning

confidence: 99%

“…Propionate is the SCFAs most produced by ASD prevalent microorganisms [ 120 , 121 ]. SCFA may exert influence on the CNS by binding to free fatty acid receptors [ 107 ] in the brain. Propionate bound to the receptor FFAR3 on human brain entholieum inhibited pathways associated with non-specific microbial infections via a CD14-dependent mechanism, suppressed expression of LRP-1 and protected the BBB from oxidative stress via NRF2 signalling [ 122 ].…”

Section: Microbial Metabolite In Autism Spectrum Disorder and Attentimentioning

confidence: 99%

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Gut instincts: vitamin D/vitamin D receptor and microbiome in neurodevelopment disorders

2020

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The gut microbiome regulates a relationship with the brain known as the gut–microbiota–brain (GMB) axis. This interaction is influenced by immune cells, microbial metabolites and neurotransmitters. Recent findings show gut dysbiosis is prevalent in autism spectrum disorder (ASD) as well as attention deficit hyperactivity disorder (ADHD). There are previously established negative correlations among vitamin D, vitamin D receptor (VDR) levels and severity of ASD as well as ADHD. Both vitamin D and VDR are known to regulate homeostasis in the brain and the intestinal microbiome. This review summarizes the growing relationship between vitamin D/VDR signalling and the GMB axis in ASD and ADHD. We focus on current publications and summarize the progress of GMB in neurodevelopmental disorders, describe effects and mechanisms of vitamin D/VDR in regulating the microbiome and synoptically highlight the potential applications of targeting vitamin D/VDR signalling in neurodevelopment disorders.

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Section: Gut Microbiota and Neurotransmitters In Autism Spectrum Disomentioning

confidence: 99%

Section: Microbial Metabolite In Autism Spectrum Disorder and Attentimentioning

confidence: 99%

Gut instincts: vitamin D/vitamin D receptor and microbiome in neurodevelopment disorders

2020

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“…Some studies tested zinc [ 54 , 55 , 56 ] or vitamin D [ 25 , 57 , 58 ] ( Table 1 c). Zinc was used as sulfate [ 55 , 56 ] or glycinate [ 54 ] and vitamin D as generic [ 25 ] or D3 [ 57 , 58 ].…”

Section: Resultsmentioning

confidence: 99%

“…Some studies tested zinc [ 54 , 55 , 56 ] or vitamin D [ 25 , 57 , 58 ] ( Table 1 c). Zinc was used as sulfate [ 55 , 56 ] or glycinate [ 54 ] and vitamin D as generic [ 25 ] or D3 [ 57 , 58 ]. All studies provided micronutrients in addition to MPH [ 25 , 55 , 56 , 57 , 58 ] or dextroamphetamine [ 54 ].…”

Section: Resultsmentioning

confidence: 99%

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Use of Non-Pharmacological Supplementations in Children and Adolescents with Attention Deficit/Hyperactivity Disorder: A Critical Review

et al. 2020

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Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children and adolescents, with environmental and biological causal influences. Pharmacological medication is the first choice in ADHD treatment; recently, many studies have concentrated on dietary supplementation approaches to address nutritional deficiencies, to which part of non-responses to medications have been imputed. This review aims to evaluate the efficacy of non-pharmacological supplementations in children or adolescents with ADHD. We reviewed 42 randomized controlled trials comprised of the following supplementation categories: polyunsaturated fatty acids (PUFAs), peptides and amino acids derivatives, single micronutrients, micronutrients mix, plant extracts and herbal supplementations, and probiotics. The reviewed studies applied heterogeneous methodologies, thus making it arduous to depict a systematic overview. No clear effect on single cognitive, affective, or behavioral domain was found for any supplementation category. Studies on PUFAs and micronutrients found symptomatology improvements. Peptides and amino acids derivatives, plant extracts, herbal supplementation, and probiotics represent innovative research fields and preliminary results may be promising. In conclusion, such findings, if confirmed through future research, should represent evidence for the efficacy of dietary supplementation as a support to standard pharmacological and psychological therapies in children and adolescents with ADHD.

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Effects of oral vitamin D supplementation on linear growth and other health outcomes among children under five years of age

Huey

Acharya

Silver

et al. 2020

Cochrane Database of Systematic Reviews

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Effect of vitamin D treatment in children with attention-deficit hyperactivity disorder

Cited by 35 publications

References 35 publications

Gut instincts: vitamin D/vitamin D receptor and microbiome in neurodevelopment disorders

Gut instincts: vitamin D/vitamin D receptor and microbiome in neurodevelopment disorders

Use of Non-Pharmacological Supplementations in Children and Adolescents with Attention Deficit/Hyperactivity Disorder: A Critical Review

Effects of oral vitamin D supplementation on linear growth and other health outcomes among children under five years of age

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