Effect of vitamin E treatment on the oxidative damage occurring in Henoch‐Schönlein purpura

Abstract

Aim: To evaluate the role of reactive oxygen molecules (ROMs) in the pathogenesis of Henoch‐Schonlein purpura and the effect of vitamin E on oxidative damage. ROMs have been suggested to contribute in many pathological conditions including renal diseases and vasculitis. Methods: The activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH‐Px) as antioxidant enzymes were measured, and the level of malondialdehyde (MDA) as an indicator of lipid peroxidation in 27 children with Henoch‐Schönlein purpura at the onset of the disease and during the remission period. The results of this study were compared with those of 11 healthy children studied as a control group. Results: With regard to all the oxidative damage parameters such as SOD, GSH‐Px and MDA, significant differences were detected between the patients and the control group in both the acute and remission periods. But no such differences were detected between patients with and those without renal involvement. In 15 patients receiving vitamin E treatment, oxidative damage parameters and clinical course showed no improvement despite significant increases in plasma vitamin E levels. Conclusion: Oxidative damage and lipid peroxidation may play an important part in the pathogenesis of Henoch‐Schonlein purpura but vitamin E given after initiation of lipid peroxidation, which is the last phase of cellular damage, is of no use in breaking down the oxidative chain reactions that have already been triggered.

Beneficial effects of creatine phosphate sodium for the treatment of Henoch–Schönlein purpura in patients with early renal damage detected using urinary kidney injury molecule-1 levels

“…Studies performed in China and other countries have shown that the incidence of HSP is related to oxidative damage and an imbalance in antioxidant protection [19]. Oxidative stress, especially lipid peroxidation, plays an important role in the renal damage of HSP [12]. Exogenous CP increases the stability of the cell membrane by reducing the production of oxygen radicals and lipid peroxidation.…”

Lipid Peroxidation and Oxidative Protein Products in Children With Episodic Fever of Unknown Origin / Lipidna Peroksidacija I Oksidativni Proteinski Produkti Kod Dece Sa Epizodinom Groznicom Nepoznatog Uzroka

“…Plasma MDA values were very similar between our groups, suggesting no significant tissue damage in children with episodic FUO. It is important to note that both erythrocyte and plasma MDA values were assessed in the afebrile phase, because lipid peroxidation products are often found in inflammatory diseases and show significantly higher values in the acute period of disease than in remission (12,24,25). The significant positive correlation of erythrocyte MDA with AOPP and albumins in our study may indicate elevated ROS levels in the febrile phase of episodic FUO and their modifying effects on lipids and proteins in this phase.…”

Neutrophil activation, protein oxidation and ceruloplasmin levels in children with Henoch-Schönlein purpura

“…Some protective mechanisms exist to limit free-radical tissue injury. Protective mechanisms consist of antioxidant enzymes, which inhibit free-radical reactions and freeradical scavengers, e.g., vitamin E and C and β-carotene [11]. The significantly lower activity of antioxidant enzyme ARYL at disease onset and considerable increase in remission suggest that antioxidant enzyme is depleted as a compensation for protection from hazardous effects of increased ROS in the active phase.…”

“…This mechanism has a crucial and probably causative role in the pathogenesis of various acute and chronic diseases, including inflammation, renal failure, and cardiovascular damage [3][4][5]. Experimental studies on oxidative injury have been carried out in glomerular diseases and vasculitis [6][7][8]; however, clinical investigations on oxidative stress in HSP are scarce [9][10][11].…”