Effect of vitamin K2 on bone mineral density and serum cathepsin K in female osteoporosis patients

Abstract

Purpose: To investigate the influence of vitamin K2 on bone mineral density, bone metabolism and serum tissue protease K (cathepsin K) in female patients with osteoporosis. Method: A total of 210 osteoporosis patients in Affiliated Hospital of Nanjing University of Chinese Medicine who met the inclusion criteria were selected from January 2017 to January 2018. The patients were randomly divided into vitamin K2 group, strontium renate group and blank control group (70 patients/group). Strontium ranelate group was orally given 2 g of strontium ranelate daily, while vitamin K2 group received 15 mg of Gulikang capsule 3 times a day. Bone mineral density (BMD) and serum osteocalcin (BGP), β-collagen degradation product (β-crosslaps), type I procollagen amino terminal propeptide (PINP), cathepsin K (cathe K) and TRAP were measured prior to drug treatment, and six months after surgery, using standard procedures. Results: Relative to the blank control, hip and lumbar spine density of vitamin K2 and strontium ranelate groups increased to varying degrees. Strontium ranelate group had significantly higher bone mineral density (BMD) than any other groups (p < 0.05), and also had the lowest osteoclast activity (β-crosslaps and TRAP) and the highest osteogenic activity (BGP and PINP). On the other hand, osteoclast and osteogenic activities increased significantly (p < 0.05) in the vitamin K2 group. Conclusion: Appropriate vitamin K2 treatment improves BMD in the hip and waist of women with osteoporosis by promoting osteogenic activity, and by reducing osteoclast activity and cathepsin K expression.

Morphological and biomechanical effects of vitamin K2 on fracture healing: An animal study on the rat tibia fracture model

“…Osteocalcin was main non-collagenous protein produced by osteoblasts and levels were increased at 24 weeks after fracture of the tibial shaft. 32 Yuanyang et al 32 investigated the effect of vitamin K2 on bone mineral density in female patients with osteoporosis and they found that appropriate vitamin K2 treatment improves bone mineral density in the hip and waist of women with osteoporosis and PINP levels were increased in vitamin K2 treatment in these group. In our study, a remarkable increase was found in biomarkers of bone metabolism such as osteocalcin, PINP, and PICP compared to the control group.…”

The Medical Benefits of Vitamin K2 on Calcium-Related Disorders

“…This correlated with an increase in osteogenic activity, therefore providing evidence that the risk of osteoporotic fracture can be reduced through nutritional supplements, specifically vitamin K 2 . However, the effect of vitamin K 2 on increasing BMD and reduced osteoclast activity was relatively small when compared to other standard medications, such as strontium ranelate of the supplements used in the study; strontium ranelate was shown to express the highest increase in BMD while also reducing osteoclast activity [ 28 ].…”