Effect of vitamin supplementation on cytokine response and on muscle damage after strenuous exercise

Petersen, Emil Wolsk; Ostrowski, Kenneth; Ibfelt, Tobias; Richelle, Myriam; Offord, Elizabeth; Halkjær-Kristensen, J; Pedersen, Bente Klarlund

doi:10.1152/ajpcell.2001.280.6.c1570

Cited by 135 publications

(109 citation statements)

References 29 publications

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“…Serum cortisol significantly lower in the vit C1500 group than in combined P and vit C-500 group The increases in plasma IL-6, IL-10, IL-1ra, and IL-8 were attenuated in runners ingesting 1500 mg, but not 500 mg, vitamin C supplements Petersen et al (2001) 20 male recreational runners; 5% downhill 90-min treadmill run at 75% VO 2 max Antioxidants (500 mg of vitamin C and 400 mg of vitamin E) for 14 days before and 7 days after exercise Plasma vitamins, creatine kinase, lymphocytes, NK cell, cytokines (IL-1ra, IL-6).…”

Section: Nutrition and Exercise-induced Immunodepressionmentioning

confidence: 81%

“…Carbohydrate intake before or during exercise had a major effect in attenuating increases in IL-6, IL-10, IL-2, IL-8 or IL-1ra in six studies (NehlsenCannarella et al, 1997;Nieman et al, 2001Nieman et al, , 2003Starkie et al, 2001;Bacurau et al, 2002;Bishop et al, 2002) but failed to show any significant effect in nine studies (Henson et al, 1999;Starkie et al, 2000;Petersen et al, 2001;Nieman et al, 2001Nieman et al, , 2003Nieman et al, , 2004Bishop et al, 2002;Lancaster et al, 2003;Chan et al, 2003). Vitamin C intake had inconsistent effects on plasma increases of IL-6, IL-10, IL-1ra and IL-8.…”

Section: Nutrition and Exercise-induced Immunodepressionmentioning

confidence: 98%

“…Although the cellular antioxidant mechanism adapts efficiently to acute and chronic exercise (Mena et al, 1991), extreme physical exercise causes oxidative damage to athletes, which is reflected by increases in plasma levels of malondialdehyde (Marzatico et al, 1997), urine 8-hydroxideoxyguanosine (Radak et al, 2000) and erythrocyte catalase activity (Tauler et al, 1999), which could relate to exercise-induced immunodepression. Vitamin C supplementation augmented the increase in lymphocyte counts after exercise (Petersen et al, 2001;Peters et al, 2001b), attenuated the serum cortisol increase in ultramarathon runners (Peters et al, 2001a, b;Nieman et al, 2002b) and attenuated the increases in inflammatory cytokines (Nieman et al, 1997b(Nieman et al, , 2000bPeters et al, 2001a, b), when ingested in doses greater than or equal to 1000 mg/day, but not on 500 mg/day. However, the risks of vitamin C excessive intake may outweigh any potential benefits, and none of the trials assessed adverse events.…”

Section: Antioxidants and Vitaminsmentioning

confidence: 99%

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Nutritional modulation of exercise-induced immunodepression in athletes: a systematic review and meta-analysis

et al. 2006

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Background: Heavy exercise induces marked immunodepression that is multifactorial in origin. Nutrition can modulate normal immune function. Objective: To assess the efficacy of nutritional supplements in exercise-induced immunodepression in athletes. Design: Systematic review. Review methods: Randomised and/or controlled trials of athletes undertaking nutritional supplements to minimise the immunodepression after exercise were retrieved. The primary outcome measure was incidence of upper respiratory tract (URT) illness symptoms after exercise, and secondary outcomes included cortisol, cell counts, plasma cytokine concentration, cell proliferative response, oxidative burst, natural killer cell activity and immunoglobulins. When data were available for a pooled estimate of the effect of intervention, meta-analyses were conducted for direct comparisons. Results: Forty-five studies were included (1603 subjects). The studies were heterogeneous in terms of exercise interventions, selection of athletes, settings and outcomes. The overall methodological quality of most of the trials was poor. Twenty studies addressed carbohydrate supplementation, eight glutamine, 13 vitamin C and four others interventions. Three trials assessed the effect of intervention on prevention of URT infections. The pooled rate ratio for URT infections after vitamin C supplementation against placebo was 0.49 (0.34-0.71). Carbohydrate supplementation attenuated the increase in cortisol and neutrophils after exercise; vitamin C attenuated the decrease in lymphocytes after exercise. No other interventions had significant or consistent effect on any of the studied outcomes. Conclusions: Although the prevention of URT infections by vitamin C was supported by two trials, further studies are needed. The available evidence failed to support a role for other nutritional supplements in preventing exercise-induced immune suppression. Larger trials with clinically relevant and uniform end points are necessary to clarify the role of these nutritional interventions.

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Section: Nutrition and Exercise-induced Immunodepressionmentioning

confidence: 81%

Section: Nutrition and Exercise-induced Immunodepressionmentioning

confidence: 98%

Section: Antioxidants and Vitaminsmentioning

confidence: 99%

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Nutritional modulation of exercise-induced immunodepression in athletes: a systematic review and meta-analysis

et al. 2006

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“…Επιπλέον, η συγκέντρωση της MDA μετά την άσκηση ήταν σημαντικά χαμηλότερη στην ομάδα που έλαβε το αντιοξειδωτικό σκεύασμα σε σχέση με την αντίστοιχη ομάδα ελέγχου. Εντούτοις, δεν υπήρξαν σημαντικές διάφορες μεταξύ της ομάδας που έλαβε το αντιοξειδωτικό συμπλήρωμα και της ομάδας που έλαβε το εικονικό σκεύασμα (Petersen, et al, 2001). …”

Section: έκκεντρη άσκηση και οξειδοαναγωγική κατάσταση του αίματοςunclassified

“…Σε αντίθεση με αυτές τις εργασίες, υπάρχουν εργασίες οι οποίες αναφέρουν ακριβώς τις αντίθετες επιδράσεις της λήψης βιταμίνης C και Ε σε δείκτες μυϊκής απόδοσης και οξειδωτικού στρες (Childs, et al, 2001;Close, et al, 2006) ή αντίστοιχες εργασίες που δεν αναφέρουν καμία επίδραση (Cannon, et al, 1990;Connolly, et al, 2006;Petersen, et al, 2001;Thompson, et al, 2001). Στην ουσία για κάθε εργασία η οποία αναφέρει μια θετική επίδραση σε ένα δείκτη μυϊκής βλάβης ή οξειδωτικού στρες υπάρχει η αντίστοιχη εργασία η οποία για τον ίδιο ή για κάποιο σχετικό δείκτη θα αναφέρει το αντίθετο αποτέλεσμα ή θα αναφέρει ότι η χορήγηση των βιταμινών δεν είχε καμία επίδραση.…”

Section: Petersen Et Al 2001unclassified

Η Επίδραση Της Έκκεντρης Προπόνησης Σε Δείκτες Μυϊκής Βλάβης Και Οξειδωτικού Στρες

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Anastasios A. Theodorou : The effect of eccentric training on muscle damage and redox status indices (Under the supervision of Athanasios Jamurtas, Assistand Professor)Antioxidant supplementation is quite often among athletes in an attempt to counteract the increased production of free radicals during exercise and especially after exerciseinduced muscle damage (eccentric). Recently an increasing number of studies reported negative effects of antioxidant supplementation on the training and cellular adaptations to chronic exercise. The aim of the present study was to investigate the effects of vitamin C and E supplementation on muscle performance, blood and muscle redox status, hemolysis and blood lipid profile in both trained and untrained individuals after acute and chronic exercise. After previous investigations of our group, a specific type of exercise was applied (eccentric) in order to produce long lasting and extensive changes in all biomarkers and examine more easily any effects of antioxidant supplementation. In a double-blinded fashion, participants received either a daily oral supplementation of vitamin C and vitamin E (n=14) or placebo (n=14) for eleven weeks. Following baseline tests, volunteers performed an eccentric exercise session two times per week for four weeks. Before and after the chronic eccentric exercise volunteers were subjected to one session of acute eccentric exercise, and physiological measurements were performed as well as blood samples and muscle biopsies (from 8 participants) were collected. The present results failed to support any effect of antioxidant supplementation; eccentric exercise similarly modified muscle damage and performance, blood redox status, hemolysis and lipid profile in both supplemented and non-supplemented groups. This is despite the fact that eccentric exercise induced marked changes in muscle damage and performance as well as redox status and lipid profile for several days after exercise. The complete lack of any effect on the physiological and biochemical outcome measures employed questions the validity of using orally antioxidant supplementation as redox modulators of muscle and redox status in healthy humans. Moreover, the lack of any effect of antioxidant supplementation on training and cellural adaptation to exercise observed in this study, opposed previous studies suggesting that antioxidant may block training adaptations.

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Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases

Bjelaković

Nikolova

Gluud

et al. 2008

Cochrane Database of Systematic Reviews

251

166

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Effect of vitamin supplementation on cytokine response and on muscle damage after strenuous exercise

Cited by 135 publications

References 29 publications

Nutritional modulation of exercise-induced immunodepression in athletes: a systematic review and meta-analysis

Nutritional modulation of exercise-induced immunodepression in athletes: a systematic review and meta-analysis

Η Επίδραση Της Έκκεντρης Προπόνησης Σε Δείκτες Μυϊκής Βλάβης Και Οξειδωτικού Στρες

Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases

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