Effect of weaning on epidermal growth factor and its receptor messenger RNA levels in various tissues of piglets

Meng, Ping; Lebel, Denis; Palin, M-F.; Pelletier, G.

doi:10.4141/cjas96-091

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…However, it is possible that pancreatic weight increased before 90 d of age. This assumption is supported by the fact that pancreatic weight (Peng et al, 1996a) and pancreatic enzyme activities increased during the weaning period (Kelly et al, 1991;Lainé et al, 1996). A role of IGF-I on pancreatic growth was suggested because IGF-I is present in pancreatic A-cells and IGF-II was observed exclusively in B-cells in humans, and the pancreas of dogs and rats (Maake and Reinecke, 1993).…”

Section: Discussionmentioning

confidence: 97%

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Ontogeny of insulin-like growth factors (IGF), IGF binding proteins, IGF receptors, and growth hormone receptor mRNA levels in porcine pancreas.

Meng

Abribat

Calvo

et al. 1998

Journal of Animal Science

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We examined the ontogeny of mRNA levels of IGF-I and -II, IGF type 1 (IGFI-R) and type II receptors (IGFII-R), IGF binding protein-1 and -3 (IGFBP-1 and -3), GH receptor (GHR), and tissue concentrations of IGF and IGFBP in the pancreas of pigs. Tissues were collected from fetuses at 90 and 110 d of gestation and from pigs at 1, 21, 90 and 180 d of age. Northern blots were performed using total RNA hybridized with 32P-labeled cDNA probes (human IGF-I and human IGFI-R) and cRNA probes (rat IGF-II, human IGFII-R, human IGFBP-1, pig IGFBP-3, and pig GHR). There were two accelerated growth stages of the pancreas: the first one at 90 d of fetal life, which is characterized by cell hyperplasia (high ratio of DNA to body weight), and the second one at postnatal 90 d, which is attributed to cell hypertrophy (high ratios of pancreatic weight, RNA, and protein to DNA). The level of IGF-II mRNA and its tissue concentration were predominant during fetal life and low thereafter. The IGF-I mRNA level was high during fetal and early postnatal life and decreased thereafter. Messenger RNA levels of IGFI-R, IGFBP-3, and GHR and concentrations of IGFBP-1 and -2 were abundant during fetal and early postnatal life. In conclusion, IGF may be involved in various physiological periods of pancreatic development in pigs.

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Section: Discussionmentioning

confidence: 97%

“…Messenger RNA for IGF-I and -II were found in various tissues from rats (Murphy et al, 1987) and pigs (Lee et al, 1993;Peng et al, 1996a). The IGFI receptor ( R) was also found on rat pancreatic A and B cells (Van Schravendijk et al, 1987).…”

Section: Introductionmentioning

confidence: 97%

Ontogeny of insulin-like growth factors (IGF), IGF binding proteins, IGF receptors, and growth hormone receptor mRNA levels in porcine pancreas.

Meng

Abribat

Calvo

et al. 1998

Journal of Animal Science

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“…The EGFR but not its ligands are expressed in human skeletal muscle. The expression of EGF and EGFR has been detected in skeletal muscle of adult mice (Frati and others 1976, Hiramatsu and others 1992) and pigs (Peng and others 1996). The present study shows that EGF, TGFα and EGFR were expressed in differentiated dog skeletal muscle.…”

Section: Discussionmentioning

confidence: 99%

Epidermal growth factor and active caspase-3 expression in the levator ani muscle of dogs with and without perineal hernia

Pérez-Gutiérrez

Argüelles

Iglesias-Nunez

et al. 2011

Journal of Small Animal Practice

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Pelvic diaphragm muscle weakening is the leading cause of perineal hernia in the dog. Survival and death signals expressed in these muscles may contribute to the pathogenesis of this disease. This study reports epidermal growth factor, transforming growth factor-alpha and epidermal growth factor receptor immunohistochemical expression in the skeletal muscle and suggests that perineal hernia in the dog is accompanied by levator ani muscle atrophy, increased expression of epidermal growth factor receptor, caspase-3 activation, and decreased expression of transforming growth factor-alpha.

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Effects of EGF receptor ligands on fetal ovine myoblasts

Harper

Buttery

2001

Domestic Animal Endocrinology

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Effect of weaning on epidermal growth factor and its receptor messenger RNA levels in various tissues of piglets

Cited by 4 publications

References 10 publications

Ontogeny of insulin-like growth factors (IGF), IGF binding proteins, IGF receptors, and growth hormone receptor mRNA levels in porcine pancreas.

Ontogeny of insulin-like growth factors (IGF), IGF binding proteins, IGF receptors, and growth hormone receptor mRNA levels in porcine pancreas.

Epidermal growth factor and active caspase-3 expression in the levator ani muscle of dogs with and without perineal hernia

Effects of EGF receptor ligands on fetal ovine myoblasts

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