Effect of wedging on the flow characteristics past tilting disc aortic valve prosthesis

Different Tilting Disc Valves Show Similar Rotation-Dependent Impairment in Hemodynamic Performance under a Tilted Implantation Position

“…This indicates systolic dysfunction due to a limited net opening angle and a diminished projected area of the tilted valve. Our results confirm the findings of Wurzel [6] and Chandran [7]. There were no substantial differences between valve sizes or types.…”

“…Due to the zero angle of attack, valve closure is delayed. Antunes [5] and Chandran [7] described similar findings. Regurgitation causes additional energy loss [14] and increases ventricular volume load, which further impedes myocardial recovery [19].…”

“…Other studies have investigated the hemodynamic implications of isolated valve tilting with a fixed axial rotation position. Chandran [7] observed an increased maximum gradient and higher Fig. 2 Definitions of valve rotation and tilting angles with respect to the aortic root.…”

“…Wurzel [6] examined its effect on the mean pressure gradient in vitro. Chandran [7] noticed an adverse outcome of tilting in vitro while Laas [8] and Kleine [9] described the influence of valve rotation in vivo. As for bileaflet valves, we could recently show that tilting leads to a significant impairment in valvular performance and increases their susceptibility to rotation [10].…”

Emerging Trends in Heart Valve Engineering: Part IV. Computational Modeling and Experimental Studies

“…29,144,160 Given the multiscale nature of the valve biomechanics, linking the organ scale to tissue and cell scales and ultimately to molecular scales, should lead to a full understanding of the disease mechanisms and processes. This would necessitate multiscale models that can seamlessly span and link these disparate scales (see Fig.…”