Effect of whey protein and glycomacropeptide on measures of satiety in normal-weight adult women

Chungchunlam, Sylvia M.S.; Henare, Sharon J.; Ganesh, Siva; Moughan, Paul J.

doi:10.1016/j.appet.2014.03.027

Cited by 23 publications

(18 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, the consumption of CMP andWPI with a high and low CMP content as a preload (60 g) drink 120 min before an ad libitum lunch was studied with 22 healthy females with a BMI of 20-25 kg m -2 . Only the WPIs induced a reduction in food intake by more than 15% in comparison to CMP [27].…”

Section: Satiatingand Weight Management Effects Of Milk Proteins In Hmentioning

confidence: 86%

“…An urgent need exists for the development of integrated research platforms involving interdisciplinary skills to address the role and mechanism of action of milk protein-derived peptides in humans. higher in all groups  (C) group of ♀: +33% CCK concentrations 30 min after lunch and lower compensatory food intake on the study day (-1.7 MJ) [21] CMP isolate, WPI with low and high CMP  Healthy ♀ subjects (n=22)  Treatments (A): CMP, (B): WPI low CMP and (C): WPI high CMP  Dose: 60 g preload 120 min before lunch  Food intake: >-15% with (B) and (C) compared to (A)  Appetite suppression and food intake: no effect of CMP [27] …”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Bioactive properties of milk proteins in humans: A review

Nongonierma

Fitzgerald

2015

Peptides

View full text Add to dashboard Cite

Many studies have demonstrated that milk protein consumption has benefits in terms of promoting human health. This review assesses the intervention studies which have evaluated potential health enhancing effects in humans following the ingestion of milk proteins. The impact of milk protein ingestion has been studied to asses their satiating, hypotensive, antimicrobial, anti-inflammatory, anticancer, antioxidant, insulinotropic properties as well as their impact on morphological modifications (e.g., muscle and fat mass) in humans. Consistent health promoting effects appear to have been observed in certain instances (i.e., muscle protein synthesis, insulinotropic and hypotensive activity). However, controversial outcomes have also been reported (i.e., antimicrobial, antiinflammatory, anticancer and antioxidant properties). Several factors including interindividual differences, the timing of protein ingestion as well as the potency of the active components may explain these differences. In addition, processing conditions have been reported, in certain instances, to affect milk protein structure and therefore modify their bioactive potential. It is thought that the health promoting properties of milk proteins are linked to the release of bioactive peptides (BAPs) during gastrointestinal digestion. There is a need for further research to develop a more in-depth understanding on the possible mechanisms involved in the observed physiological effects. In addition, more carefully controlled and appropriately powered human intervention studies are required to demonstrate the health enhancing properties of milk proteins in humans.

show abstract

Section: Satiatingand Weight Management Effects Of Milk Proteins In Hmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 98%

Bioactive properties of milk proteins in humans: A review

Nongonierma

Fitzgerald

2015

Peptides

View full text Add to dashboard Cite

show abstract

“…There is considerable evidence that dietary proteins, in general, are more satiating than carbohydrate and fat (1)(2)(3)(4)(5) , and that among protein sources dairy whey protein is particularly satiating (6)(7)(8) . In comparison with carbohydrate, ingestion of whey protein has been shown to reduce subsequent energy intake relative to glucose (9,10) , sucrose (11) or maltodextrin (12)(13)(14) . In our own earlier study with healthy, normal-weight human subjects (13)(14)(15) , we found that whey protein, when provided as the main fraction of a preload meal, suppressed subsequent food intake and increased subjective ratings of fullness relative to maltodextrin.…”

mentioning

confidence: 99%

“…In comparison with carbohydrate, ingestion of whey protein has been shown to reduce subsequent energy intake relative to glucose (9,10) , sucrose (11) or maltodextrin (12)(13)(14) . In our own earlier study with healthy, normal-weight human subjects (13)(14)(15) , we found that whey protein, when provided as the main fraction of a preload meal, suppressed subsequent food intake and increased subjective ratings of fullness relative to maltodextrin. Consumption of whey protein has been shown to result in a greater reduction in subsequent food intake and increase in subjective ratings of satiety compared with casein (16,17) , egg albumen (11,18) , milk protein (19) , soya protein (17) , tuna (18) and turkey meat (18) .…”

mentioning

confidence: 99%

Effect of whey protein and a free amino acid mixture simulating whey protein on measures of satiety in normal-weight women

et al. 2016

Self Cite

View full text Add to dashboard Cite

Dietary protein is considered more satiating than carbohydrate, and whey protein is more satiating than other protein sources. The purported satiating effect of whey protein may be due to direct effects of the unique mixture of proteins in whey, due to the effects of peptides released upon digestion and/or its amino acid composition. The objective of the present study was to compare the satiating effects of intact whey protein isolate (WPI) or a free amino acid mixture (AAM) simulating the amino acid composition of the WPI. A single-blind completely randomised block design included twenty, healthy, adult women (age 24·2 (sem 0·8) years) of normal weight (BMI 22·7 (sem 0·4) kg/m2). Following consumption of isoenergetic (approximately 1800 kJ) preload meals enriched (52 g amino acid equivalent) with WPI or AAM, consumption of an ad libitum test meal 120 min later and subjective feelings of appetite using visual analogue scales (VAS) were determined. There were no significant differences (P=0·24) in the ad libitum test meal intakes between the WPI (268·5 (sem 27·3) g) and the AAM (238·4 (sem 22·7) g) preload meals. Subjective VAS ratings of appetite did not differ significantly between the WPI and the AAM preload meals (P>0·05). Intact whey protein and a free AAM simulating the whey protein showed similar effects on satiety. This suggests that the satiating effect of whey protein may be related to its specific amino acid composition.

show abstract

“…As whey protein is an abundant by-product in cheese production (10 litres of milk produces about 9 litres of whey during cheese manufacturing), it is considered an inexpensive source of high-quality protein that can be used in functional foods claiming health benefits (7) . Several studies conducted in humans have shown that whey supplementation affects appetite and reduces food intake (8)(9)(10) . However, it is unclear whether the consumption of whey affects the central mechanisms involved in food intake control.…”

mentioning

confidence: 99%

Dietary whey reduces energy intake and alters hypothalamic gene expression in obese phyto-oestrogen-deprived male rats

et al. 2016

View full text Add to dashboard Cite

Removing dietary phyto-oestrogens in adult male rats causes obesity and diabetes. As whey proteins have been reported to reduce food intake and improve glucose homoeostasis, we investigated whether they could attenuate susceptibility to obesity and diabetes due to phytooestrogen deprivation. To this end, thirty male Wistar rats were fed a high-phyto-oestrogen (HP) or a phyto-oestrogen-free (PF) diet for 10 weeks; six rats from each group were killed. The remaining HP animals (six animals) continued receiving the HP diet for 6 weeks. The remaining PF rats (twelve rats) were divided in two groups: one was given the PF diet and the other a variation of the PF diet plus whey protein (PF-W). Body weight, food intake and adipose tissue weights were recorded. Hypothalamic mRNA expressions of orexigenic (neuropeptide Y, agouti-related protein (AgRP)) and anorexigenic (pro-opiomelanocortin (POMC), cocaine-amphetamine-related transcript (CART)) neuropeptides were quantified by real-time PCR. Serum glucose, insulin and total thyroxine (T4), thyroid-stimulating hormone, testosterone and oestradiol were assessed. After 10 weeks of PF diet, increased body weight, adiposity and energy intake, with up-regulation of AgRP and down-regulation of POMC', were observed. Longer treatment exacerbated these results, increased total T4 levels, reduced oestradiol levels and impaired glucose homoeostasis. PF-W reduced energy intake and increased POMC expression; however, body weight and adiposity remained unchanged. PF-W could not prevent the hormonal changes or the high circulating glucose levels induced by phytooestrogen deprivation, but reduced fasting insulin. These data demonstrate that, although 6 weeks of whey administration could not prevent obesity in phyto-oestrogen-deprived rats, the reduction in energy intake and circulating insulin could be beneficial with longer treatments.

show abstract

Effect of whey protein and glycomacropeptide on measures of satiety in normal-weight adult women

Cited by 23 publications

References 31 publications

Bioactive properties of milk proteins in humans: A review

Bioactive properties of milk proteins in humans: A review

Effect of whey protein and a free amino acid mixture simulating whey protein on measures of satiety in normal-weight women

Dietary whey reduces energy intake and alters hypothalamic gene expression in obese phyto-oestrogen-deprived male rats

Contact Info

Product

Resources

About