The aim of the present study was to investigate the mediating role of emotional coping ability in the relationship between EI and wellness. The study was conducted in public and private hospitals and 766 valid responses were considered for the analysis. Information related to the demographic, correlation coefficient, direct and indirect effects, and the path coefficient of the model was presented in tabular form. Data were analysed using SPSS 22 and Smart PLS 3. Findings show that the path between EI and wellness was mediated by emotional coping ability and the effect was found to be statistically significant. The R2 for the model was found to be 41.5%. Moreover, the correlation coefficient ranged from 0.527–0.601. The present study was able to establish the mediating effect of emotional coping ability and proposes a model of wellness, which is of great significance for the psychological intervention of nursing professionals in the future.