Effect of Zinc as an Add-On to Metformin Therapy on Glycemic control, Serum Insulin, and C-peptide Levels and Insulin Resistance in Type 2 Diabetes Mellitus Patient

Younis, Hend Y.; Thanoon, Imad A.; Fadhil, Nabeel N.; Merkhan, Marwan M.

doi:10.52711/0974-360x.2022.00198

Cited by 15 publications

(11 citation statements)

References 19 publications

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“…Additionally, the activity of both extracts was more in yeast than in bacteria. 22 As an antioxidant, extract of these plants could find an application in a wide range of chronic diseases which are associated with oxidative stress, such as, diabetes, [23][24][25][26] hyperlipidemia, 27,28 metabolic syndromes, 29 ulcerative diseases, [30][31][32][33] and thyroid disorders. 34 The potency of these plant extracts could be comparable to commonly used antioxidant vitamins in terms of potential therapy.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Comparative Studies, Antioxidant and Antimicrobial of Artemisia and Star Anise

Abid¹,

Abachi²

2023

Pharmacogn J.

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The tradition of investigating plants and extensively scrutinizing their biologically or pharmacologically active compounds has markedly increased due to their fewer adverse effects compared to synthetic drugs. Through this study, we aim to establish a phytochemical screening and analyze and compare the antioxidant and antimicrobial properties of Artemisia and star anise. The antioxidant characteristics of plant extracts we assessed, the chemical bonds and components composition were analyzed in the sample and further experiments were done to assess the antimicrobial activities. On the results, we found that all the extracts of both the species were very impactful in the inhibition of E. coli, C. Albicans, and S. aureus. However, S. aureus was more sensitive to star anise and E. coli and C. albicans were inhibited better through the alcoholic extracts of Artemisia vulgaris. Star anise has a higher and more effective antioxidant activity against DPPH with a calculated value of 78.3 % at a concentration of 750 ppm, at a concentration of 500 ppm it was 65.3% and in the least concentration of 250 ppm, it was 23.3% compared to Artemisia vulgaris. Additionally, both extracts possessed marked antifungal action.

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Section: Discussionmentioning

confidence: 99%

Phytochemical Comparative Studies, Antioxidant and Antimicrobial of Artemisia and Star Anise

Abid¹,

Abachi²

2023

Pharmacogn J.

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“…For example, statins (41,42), proton-pump inhibitors (43,44), CNS drugs (45,46), chemotherapeutic agents (47,48), drug used for diabetes (49,50). Moreover, the same positive effects obtained from beta carotene could be provided by other harmless OTC drugs, such as, vitamins (51,52), or minerals (53,54), or herbal remedies (55) or xanthine oxidase inhibitors (allopurinol) (56,57). Nevertheless, claiming potentially positive agents from these drugs need experimental in vivo studies on laboratory animal before their clinical application into human, if possible.…”

Section: Discussionmentioning

confidence: 99%

The Protective Effect of Beta Carotene Against Amikacin Induced Nephrotoxicity

Khalaf¹,

Althanoon²

2023

Mil. Med. Sci. Lett.

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Background:The rapid loss of kidney function is known as nephrotoxicity. The harmful effects of medications may cause this. Amikacin-related nephrotoxicity is an excellent illustration of such a case. Amikacin is a synthetic aminoglycoside that works against the majority of gram-negative bacteria and, in some circumstances, can be harmful to the kidneys. One of the many methods used to prevent or decrease this toxicity is the use of antioxidant substances with amikacin. Beta carotene is an antioxidant carotenoid pigment. The aim of the current study: is to illustrate the ameliorative effect of beta carotene against the nephrotoxicity caused by amikacin when given before or during the treatment of amikacin. The study also evaluates the nephrotoxicity evoked by amikacin. Material and Methods: Five groups of animals were used (seven rats in each group): the control group, the amikacin group, the beta carotene group, the beta carotene with the amikacin group, and the group given beta carotene first, then added amikacin later together with the beta carotene. Results:The results of the current study demonstrate that when comparing the amikacin-treated group to the control group, there was a significant elevation (p ˂ 0.05) of serum creatinine and urea levels. The results also showed that when comparing the amikacin -treated group to the group treated with beta carotene during amikacin treatment for 14 days, there was a significant reduction (p ˂ 0.05) in serum creatinine and urea levels. Furthermore, in comparison of the amikacin -treated group to the group treated with beta carotene only for 9 days and continued with amikacin for 14 days, there was a significant reduction (p ˂ 0.05) in serum creatinine and urea levels. Also, there were significant decreases (near normal) in serum creatinine and urea. Histological findings confirmed these findings; there was damage to renal tissue in the amikacin -treated group, whereas groups treated with beta carotene and amikacin showed improvements in histological images. Discussion and conclusion: According to the results of renal function tests and histological findings, treatment with AMK only causes renal toxicity in rats, and when rats are treated with BC before and during AMK treatment or even only during AMK treatment, BC can prevent this renal toxicity by decreasing serum urea and creatinine levels, which, in agreement with the previous study, leads us to conclude that BC offers significant protection against AMK-induced nephrotoxicity, The results also showed the efficiency of two methods of administration of beta carotene in giving the required protection against renal toxicity (not preferring one method over the other).

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“…enero-junio 2024 Gac Med Bol 2024; 47(1): Some researchers try to find the effect of metformin on magnesium and zinc in type II diabetes patients [21][22][23] , in chronic kidney disease 24 , before and after surgery 25 and one research tries to find the effect of metformin on zinc and magnesium level23 Other type of research try to find the effect of zinc and magnesium as an added complement to metformin treatment [26][27][28][29] . The third type of research tries to determine the level of magnesium and zinc in polycystic ovary syndrome 12,16,30 .…”

Section: G M Bmentioning

confidence: 99%

Efecto del fármaco metformina sobre los niveles de zinc y magnesio en mujeres con síndrome de ovario poliquístico

Abdulmunem Ibrahim

2024

GMB

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El síndrome de ovario poliquístico implica oligomenorrea y/o anovulación por exceso de testosterona o LH, además de trastornos metabólicos que pueden resultar en una disminución de los niveles de vitaminas y minerales importantes, incluidos los niveles de zinc y magnesio. Objetivo:mostrar si el tratamiento con metformina para mujeres de ovario poliquístico puede cambiar los niveles de zinc y magnesio en esas mujeres.Métodos:este estudio involucra a 23 mujeres de ovario poliquístico diagnosticadas temprano que no toman metformina y 16 mujeres ováricas poliquísticas que toman metformina 850mg dos veces al día durante al menos tres meses. FSH, LH, testosterona, estradiol, prolactina, SHBG, insulina en ayunas, glucosa en ayunas, magnesio y zinc se miden en el segundo día del ciclo. Resultados:los pacientes sin metformina mostraron aumentos significativos en la relación LH, FSH y testosterona libre en valores de p de 0,03, 0,037 y 0,009 respectivamente.El zinc mostró una correlación directa con el estradiol en pacientes que no recibieron metformina y una correlación indirecta con el índice de masa corporal en pacientes en tratamiento con metformina.Conclusión:el zinc es un elemento importante para la fertilidad femenina, ya que puede mejorar el nivel de estradiol puede deberse a su actividad antioxidante que disminuye la reacción inflamatoria en la región pélvica y mejora la función del ovario.El aumento en el nivel de zinc tiene un efecto inverso en el índice de masa corporal. Sin embargo, el tratamiento con metformina en este estudio no mostró ningún efecto sobre el nivel de magnesio y zinc en mujeres ováricas poliquísticas.

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Effect of Zinc as an Add-On to Metformin Therapy on Glycemic control, Serum Insulin, and C-peptide Levels and Insulin Resistance in Type 2 Diabetes Mellitus Patient

Cited by 15 publications

References 19 publications

Phytochemical Comparative Studies, Antioxidant and Antimicrobial of Artemisia and Star Anise

Phytochemical Comparative Studies, Antioxidant and Antimicrobial of Artemisia and Star Anise

The Protective Effect of Beta Carotene Against Amikacin Induced Nephrotoxicity

Efecto del fármaco metformina sobre los niveles de zinc y magnesio en mujeres con síndrome de ovario poliquístico

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