Effect of zinc oxide nanoparticles on diabetes development and complications in diabetic rats compared to conventional zinc sulfate and metformin

Shaban, Eman; El‐Aziz, Mahmoud E. Abd; Ibrahim, K.; Nasr, Soad M.; Desouky, Hassan M.; Elbakry, Hagar

doi:10.1016/j.bcab.2022.102538

Cited by 6 publications

(2 citation statements)

References 55 publications

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“…The upregulation of the ALP with the administration of zinc contributed to the recovery of the liver tissue via its protective action. 58,59 The delivery of Zn, ZnPcN, and formulation ZnPcPNs demonstrated normal glomerular capillary blood vessels without any abnormalities in proximal convoluted tubular tissue. 60 With reference to Alomari et al, 56 the zinc nanosystems decreases the TGF-β1 and collagen IV expression and create the antifibrotic effect, which mainly contributes to the recovery of kidney damage caused by STZ.…”

Section: Semmentioning

confidence: 97%

Zinc–Phthalocyanine Loaded PLGA–PVA–Chitosan Nanosystem for the Enhancement of Antidiabetic Activity

Govardhane,

Shende

2023

Mol. Pharmaceutics

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Zinc, one of the most common nutraceutical agents, proved to be effective for diabetes as it regulates the blood glucose level by inhibiting glucagon secretion. However, the hepatotoxicity of zinc creates necrosis, hepatic glycogen depletion, and apoptosis of hepatocytes at the concentration of 10 μg/kg. Phthalocyanine, a bluecolored compound, is an aromatic macrocyclic compound with good antioxidant ability owing to its heterocyclic nitrogen conjugation. The conjugation of zinc with phthalocyanine aimed to reduce the toxicity associated with zinc and enhance the antidiabetic activity at a lower dose. Hence, the present research work possessed the insights of the synthetic aspect of zinc with phthalocyanine along with its entrapment in the poly(lactic-co-glycolic acid) (PLGA)−chitosan nanosystem via oral administration in the treatment of diabetes. A nanoprecipitation technique was implemented for the synthesis of PLGA chitosan nanoparticles, and formulation was further optimized using a central composite design. Twenty trials provided by the software selected optimum concentrations of PLGA, poly(vinyl alcohol) (PVA), and chitosan in consideration with particle size up to 335.6 nm, zeta potential 27.87 mV, and entrapment efficiency of 75.67 ± 8.13%. Addition of chitosan to the nanocarrier system for controlling the release of the drug for 3 days was accompanied by the improvement in the glucose level within 28 days. The delivery of the nanoparticles showed enhancement in the cholesterol, triglyceride, alkaline phosphatase (ALP), urine parameters, and proinflammatory cytokines. The application of DoE (design of experiments) for the optimization of the nanoparticles established a controlled release formulation for diabetes, which displayed safety and effectiveness in streptozotocin (STZ)-induced diabetic rats.

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Section: Semmentioning

confidence: 97%

Zinc–Phthalocyanine Loaded PLGA–PVA–Chitosan Nanosystem for the Enhancement of Antidiabetic Activity

Govardhane,

Shende

2023

Mol. Pharmaceutics

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“…Additionally, there is no need for external reducing, capping, and stabilizing agents [9]. Meanwhile, green-based synthesized ZnO NPs have been utilized in many biological applications including anti-inflammatory properties without having any negative effects [10], anti-cancer [11], anti-diabetic [12], anti-fungal [13] and anti-bacterial activities [14]. ZnO is classified as a chemical that is "generally recognized as safe" (GRAS) by the U.S. Food and Drug Administration (FDA) [15].…”

Section: Introductionmentioning

confidence: 99%

Comparing the Use of Washingtonia Filifera Seed Extract in Various Solvents for ZnO Nanoparticle Synthesis, Characterization, and its Potential Anti- inflammatory and Biological Applications

Jalil,

Mhamedsharif,

Shnawa

et al. 2023

Preprint

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The present study involves the green synthesis of zinc oxide nanoparticles ZnO NPs using three different solvents for plant extract of ethanol (EtOH), methanol (MeOH), and double distilled water (ddH2O) in a method that is rapid, cost-effective, and environmentally friendly. The novelty of this study was creating ZnO NPs from Washingtonia filifera plant seed extract. Green fabricated ZnO NPs were characterized via UV–Vis spectroscopy, Fourier transform infrared (FT-IR), energy-dispersive spectroscopy (EDX), and X-ray diffraction (XRD). SEM data showed the efficacy of palm seed extract metabolites in fabricating spherical shape of ZnONPs, with an avarage size of 50, 71.6, and 81.6 nm for ddH2O, EtOH, and MeOH Zn ONPs, respectively. FT-IR analysis showed varied absorption peaks related to fuctional group of plant extract and nanoparticle formation. Moreover, data analysis revealed that the antimicrobial activity against pathogenic Gram-positive and Gram-negative bacteria and fungi was dose-dependent and exhibited variable inhibition zone values. In comparison to the plant extract alone, which provides minimum antimicrobial activity, the ZnO NPs prepared from this plant inhibit bacterial activity more efficiently. MeOH-ZnO NPs formed a maximum clear zones, 23.5 ± 0.3, 26.0 ± 0.3, and 19.8 ± 0.3 mm, at highest concentrations of 500 µg/ml against S. aureus, P. aeruginosa, E. coli, respectively. EtOH-ZnO NPs exhibit 82.2, 82.2, and 67.2% of mycelial inhibition after 6 days of treatment with ZnO NPs for A. niger, A. fumigatus and S. apiospermum, respectively. Also, biosynthesized ZnO NPs showed a potent anti-inflammatory activity of were dose-dependent. The present anti-bacterial activities were increased as the NPs concentration increased. The W. filifera-mediated ZnO NPs showed strong antimicrobial activity against clinical pathogens compared to standard drugs. This suggests that plant-based synthesis of NPs can be an excellent strategy for developing versatile and eco-friendly biomedical products.

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Nanomedicines based on trace elements for intervention of diabetes mellitus

Ruan,

Guo,

Ren

et al. 2023

Biomedicine & Pharmacotherapy

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Effect of zinc oxide nanoparticles on diabetes development and complications in diabetic rats compared to conventional zinc sulfate and metformin

Cited by 6 publications

References 55 publications

Zinc–Phthalocyanine Loaded PLGA–PVA–Chitosan Nanosystem for the Enhancement of Antidiabetic Activity

Zinc–Phthalocyanine Loaded PLGA–PVA–Chitosan Nanosystem for the Enhancement of Antidiabetic Activity

Comparing the Use of Washingtonia Filifera Seed Extract in Various Solvents for ZnO Nanoparticle Synthesis, Characterization, and its Potential Anti- inflammatory and Biological Applications

Nanomedicines based on trace elements for intervention of diabetes mellitus

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