Effect of Zinc Supplement on Prevention of PPROM and Improvement of some Pregnancy Outcomes in Pregnant Women with a History of PPROM: A Randomized Double -Blind Controlled Trial

Shahnazi, Mahnaz; Khalili, Azizeh Farshbaf; Azimi, Shiva

doi:10.5812/ircmj.41931

Cited by 3 publications

(4 citation statements)

References 21 publications

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“…Another study found that plasma zinc concentrations in women with PPROM were significantly lower than in controls, lending credence to our findings (27). On the contrary, it was discovered in a study looking into the effect of zinc supplementation in preventing PPROM that zinc sulfate intake had no effect on PPROM prevention (28). Similarly, researchers discovered that zinc supplementation had no effect on the incidence of PPROM in a study of 196 women who were 19-20 weeks pregnant (29).…”

Section: Discussionmentioning

confidence: 99%

Is there any connection between zinc deficiency and poor obstetric outcomes in pregnancy?

DEĞER

Turan

Peker

2022

Jinekoloji-Obstetrik Ve Neonatoloji Tıp Dergisi

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Aim: The present study aims to examine the effects of zinc deficiency on maternal and fetal outcomes during pregnancy. Material-method: The study was carried out in a secondary care hospital between 2020 January and 2020 December. Demographic data of all patients, zinc, hemoglobin (Hb), hematocrit (Hct) levels at birth and adverse pregnancy outcomes such as oligohydramnios, preterm delivery, preeclampsia, preterm premature rupture of membranes (PPROM), intrauterine growth retardation (IUGR) were recorded. Maternal serum zinc levels of

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Section: Discussionmentioning

confidence: 99%

Is there any connection between zinc deficiency and poor obstetric outcomes in pregnancy?

DEĞER

Turan

Peker

2022

Jinekoloji-Obstetrik Ve Neonatoloji Tıp Dergisi

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“…It was reported that 40 mg daily zinc sulfate supplementation prevented the risk of preterm prelabor rupture of membranes during the mid‐ and late trimesters in pregnant women 165 . Interestingly, this trace mineral is considered an alternative to many of the antibiotics that are used for the treatment of diarrhea in newborn calves 166,167 . It plays vital roles in synthesizing humoral immunity and IgG in mammary tissue, and is secreted in colostrum and taken in by newborn calves 168,169 .…”

Section: Factors Affecting On Maternal Immune Responsementioning

confidence: 99%

“…165 Interestingly, this trace mineral is considered an alternative to many of the antibiotics that are used for the treatment of diarrhea in newborn calves. 166,167 It plays vital roles in synthesizing humoral immunity and IgG in mammary tissue, and is secreted in colostrum and taken in by newborn calves. 168,169 Dairy cows receiving higher zinc in their feed have higher production of immunoglobulins and improved passive immunity in their calves.…”

Section: Nutritional Statusmentioning

confidence: 99%

The protective role of maternal genetic immunization on maternal‐fetal health and welfare

Ahmed,

Jiang,

Liu

et al. 2023

Intl J Gynecology & Obste

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Pregnancy is a critical period associated with alterations in physiologic, biologic, and immunologic processes, which can affect maternal‐fetal health through development of several infectious diseases. At birth, neonates have an immature immune system that makes them more susceptible to severe viral infections and diseases. For this reason, different maternal nutritional and immunization interventions have been used to improve the immune and health status of the mother and her neonate through passive immunity. Here, we reviewed the protective role of maternal immunization with different types of vaccines, especially genetic vaccines, during pregnancy in maternal‐fetal health, immune response, colostrum quality, immune response, and anti‐oxidative status. For this purpose, we have used different scientific databases (PubMed and Google Scholar) and other official web pages. We customized the search period range from the year 2000 to 2023 using the key words “maternal immunization” OR “gestation period/pregnancy” OR “genetic vaccination” OR “maternal‐fetal health” OR “micronutrients” OR “neonatal immunity” “oxidative stress” OR “colostrum quality”. The evidence demonstrated that inactivated or killed vaccines produced significant immune protection in the mother and fetus. Furthermore, most recent studies have suggested that the use of genetic vaccines (mRNA and DNA) during pregnancy is efficient at triggering the immune response in mother and neonate without the risk of undesired pregnancy outcomes. However, factors such as maternal redox balance, nutritional status, and the timing of immunization play essential roles in regulating immune response inflammatory status, antioxidant capacity, and the welfare of both the pregnant mother and her newborn.

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“…Furthermore, that disruption of collagen occurs as a result of the effects of zinc-dependent matrix metalloproteinase and tissue-specific inhibitors. The effect of supplementation (daily 40 mg zinc sulphate) vs. placebo treatment to prevent PPROM during the second and early third trimesters in pregnant women who had previously been affected was conducted by Shahnazi et al [52] among women attending an Iranian midwifery clinic. Unfortunately, the researchers were unable to demonstrate any superiority of zinc supplementation on the prevention of PPROM and improvement of gestational age at birth or any anthropometric measurements.…”

Section: Zincmentioning

confidence: 99%

Do Micronutrient and Omega-3 Fatty Acid Supplements Affect Human Maternal Immunity during Pregnancy? A Scoping Review

et al. 2022

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Maternal dietary micronutrients and omega-3 fatty acids support development of the fetal and neonatal immune system. Whether supplementation is similarly beneficial for the mother during gestation has received limited attention. A scoping review of human trials was conducted looking for evidence of biochemical, genomic, and clinical effects of supplementation on the maternal immune system. The authors explored the literature on PubMed, Cochrane Library, and Web of Science databases from 2010 to the present day using PRISMA-ScR methodology. Full-length human trials in English were searched for using general terms and vitamin A, B12, C, D, and E; choline; iodine; iron; selenium; zinc; and docosahexaenoic/eicosapentaenoic acid. Of 1391 unique articles, 36 were eligible for inclusion. Diverse biochemical and epigenomic effects of supplementation were identified that may influence innate and adaptive immunity. Possible clinical benefits were encountered in malaria, HIV infections, anemia, Type 1 diabetes mellitus, and preventing preterm delivery. Only limited publications were identified that directly explored maternal immunity in pregnancy and the effects of micronutrients. None provided a holistic perspective. It is concluded that supplementation may influence biochemical aspects of the maternal immune response and some clinical outcomes, but the evidence from this review is not sufficient to justify changes to current guidelines.

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Effect of Zinc Supplement on Prevention of PPROM and Improvement of some Pregnancy Outcomes in Pregnant Women with a History of PPROM: A Randomized Double -Blind Controlled Trial

Cited by 3 publications

References 21 publications

Is there any connection between zinc deficiency and poor obstetric outcomes in pregnancy?

Is there any connection between zinc deficiency and poor obstetric outcomes in pregnancy?

The protective role of maternal genetic immunization on maternal‐fetal health and welfare

Do Micronutrient and Omega-3 Fatty Acid Supplements Affect Human Maternal Immunity during Pregnancy? A Scoping Review

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