Effect of Zuogui Pill (左归丸) on monoamine neurotransmitters and sex hormones in climacteric rats with panic attack

Li, Xiaoyü; Wang, Xiaoyun

doi:10.1007/s11655-016-2095-4

Cited by 4 publications

(2 citation statements)

References 20 publications

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“…Morris water maze test indicated that ZGP could repress the damage of MCAO/R by inhibiting escape latency and improving the percentage of time spent in the target quadrant. In a publication of Li and Wang [29], the treatment with ZGP in climacteric rats can recover the behavior from panic attacks. Another study reports that ZGP has protective effects on rat optic nerve [30].…”

Section: Discussionmentioning

confidence: 99%

Zuogui Pill Attenuates Neuroinflammation and Improves Cognitive Function in Cerebral Ischemia Reperfusion-Injured Rats

Liu

Dai

Yang

et al. 2021

Neuroimmunomodulation

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Introduction: Cerebral ischemia and reperfusion (CI/R) injury is a devasting cerebrovascular disease, accompanied with ischemia stroke, cerebral infarction. Zuogui Pill (ZGP), as a Chinese traditional medicine, is proved to be effective in many diseases and cancers. Our study aimed to detect the roles of ZGP in CI/R injury. Methods: Neural stem cells were isolated from rats and induced by oxygen and glucose deprivation and recovery. CCK-8 and flow cytometry were applied to assess the function of ZGP on cell viability and apoptosis. Rat CI/R injury models were established by the middle cerebral artery occlusion and reperfusion. The function of ZGP on CI/R injury was identified via evaluating modified neurological severity score, infarct area, and cognitive impairment. Results: Compared to the control, the cell viability was obviously decreased in the oxygen and glucose deprivation and recovery (OGD/R) group, while the adverse influence on cells was reversed by cultured plus 10% ZGP serum. Consistently, ZGP attenuated the influence of OGD/R on cell apoptosis. More importantly, ZGP could alleviate CI/R injury of rats by reducing neurological damage and infarct area and promoting cognitive function. Conclusion: This study provided protective roles of ZGP on cell viability and apoptosis induced by OGD/R. In addition, ZGP played protective roles on neuroinflammation and cognitive function in rats.

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Section: Discussionmentioning

confidence: 99%

Zuogui Pill Attenuates Neuroinflammation and Improves Cognitive Function in Cerebral Ischemia Reperfusion-Injured Rats

Liu

Dai

Yang

et al. 2021

Neuroimmunomodulation

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“…More importantly, ZGW is associated with many neuro-systemic disorders. According to a study on monoamine neurotransmitters in climacteric rats, the treatment of ZGW apparently decreases the time spent in elevated T-maze and the levels of 5-hydroxytryptamine and noradrenalin, indicating ZGW may participate in the nerve conduction [13]. Another study by Wang et al [14] proposes ZGW has protective effects on retina ganglion cells after optical nerve clipping contusion in rats.…”

Section: Introductionmentioning

confidence: 99%

Zuoguiwan Ameliorates Cognitive Deficits and Neuro-Inflammation in Streptozotocin-Induced Alzheimer’s Disease Rats

Liu

Zhong

Dai

et al. 2021

Neuroimmunomodulation

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Introduction: Alzheimer’s disease is the most popular neurodegenerative disorder with no effective drugs to stop the progression. Zuoguiwan (ZGW), a traditional Chinese herbal medicine, has been applied in many diseases. Our study aimed to detect the function and mechanisms of ZGW in Alzheimer’s disease (AD). Methods: The rat models of AD were established by streptozotocin (STZ), and the function of ZGW on cognitive dysfunction was measured with the Morris water maze test. The concentration of pro-inflammatory mediators was accessed by enzyme-linked immunosorbent assay. The relative mRNA expression of ERβ was detected by real-time quantitative PCR. Results: The treatment with ZGW could suppress the cognitive impairment by the findings of escape latency and time spent in the target quadrant and the increased concentration of IL-1β, IL-6, and TNF-α induced by STZ. STZ might repress the mRNA levels of ERβ, and ZGW management weakened the declined mRNA expression of ERβ. ZGW might play a protective role in AD rats against the injury of STZ on cognition and neuro-inflammation by improving the mRNA expression of ERβ. Conclusion: The results indicated that ZGW might be a novel therapeutic strategy to slow the process of AD by modulating ERβ.

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Zuogui Wan alleviated maternal kidney-yin deficiency-induced thymic epithelial cell dysfunction in newborn rats through Wnt/β-catenin signaling pathway

Chen

Ren

Cao

et al. 2021

Journal of Ethnopharmacology

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Effect of Zuogui Pill (左归丸) on monoamine neurotransmitters and sex hormones in climacteric rats with panic attack

Abstract: Pretreatment with ZGP in climacteric rats may improve the behavior of panic attack, which may be related to increased 5-HT and NE in the brain.

Cited by 4 publications

References 20 publications

Zuogui Pill Attenuates Neuroinflammation and Improves Cognitive Function in Cerebral Ischemia Reperfusion-Injured Rats

Zuogui Pill Attenuates Neuroinflammation and Improves Cognitive Function in Cerebral Ischemia Reperfusion-Injured Rats

Zuoguiwan Ameliorates Cognitive Deficits and Neuro-Inflammation in Streptozotocin-Induced Alzheimer’s Disease Rats

Zuogui Wan alleviated maternal kidney-yin deficiency-induced thymic epithelial cell dysfunction in newborn rats through Wnt/β-catenin signaling pathway

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