Effect, on Serum Lipid Levels of Ω-3 Fatty Acids, of Ingesting Fish-Oil Concentrate

Gent, C.M. van; Luten, J. B.; Bronsgeest-Schoute, H.C.; Ruiter, A.

doi:10.1016/s0140-6736(79)92374-2

Cited by 33 publications

(5 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These methyl esters originated during the urea inclusion complex formation step. In our dose-response study (1,2), there was no objection to this methylation. It can possibly be avoided by substituting methanol with another solvent, e.g., ethanol, during the urea inclusion compound formation.…”

Section: Jaocsmentioning

confidence: 71%

“…In a recent study on the dose-response relationship between 6o3 fatty acid intake and certain blood parameters in human subjects, an 603 fatty acid concentrate was used (1,2). Such a concentrate was preferred to "whole" fish oil because it keeps the daily amount of fatty acids ingested as low as possible and other fatty acids, which might be physiologically active, are then present only in small amounts or are completely absent.…”

Section: Introductionmentioning

confidence: 99%

“…From among the different methods available for the preparation of concentrates of polyunsaturated fatty acids from natural sources (3), low-temperature crystallization and urea inclusion compound formation (4-7) are suitable, as they-allow the handling of large quantities of fatty acids (ca. 3,000 g of 603 fatty acids were needed [1,2] ).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Preparation of an ω3 fatty acid concentrate from cod liver oil

Haagsma

Gent

Luten³

et al. 1982

J Americ Oil Chem Soc

111

View full text Add to dashboard Cite

show abstract

Section: Jaocsmentioning

confidence: 71%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Preparation of an ω3 fatty acid concentrate from cod liver oil

Haagsma

Gent

Luten³

et al. 1982

J Americ Oil Chem Soc

111

View full text Add to dashboard Cite

show abstract

“…Dietary n-3 fatty acids lower serum triglyceride levels (12,19,(146)(147)(148)(149)(150) apparently by reducing liver triglyceride production and VLDL secretion (151)(152)(153)(154). It is not known if n-3 fatty acids also inhibit triglyceride synthesis in the enterocyte, but it is known that fat meals high in n-3 fatty acids do not usually produce the hyperlipemia characteristic of meals high in saturated fat (2,98}.…”

Section: Absorption Of N-3 Fatty Acidmentioning

confidence: 99%

Absorption and transport of fat in mammals with emphasis on n−3 polyunsaturated fatty acids

Nelson

Ackman

1988

Lipids

117

View full text Add to dashboard Cite

The current state of knowledge concerning the absorption and transport of dietary fat with emphasis on long-chain polyunsaturated n-3 fatty acids in mammals is reviewed. It is apparent that long-chain polyunsaturated n-3 fatty acids, either as free acids or as part of triglycerides, are readily absorbed in the gut and transported by the circulatory system. Indeed, it would appear that long-chain polyunsaturated n-3 fatty acids are digested, absorbed and transported similarly to other long-chain fatty acids with only minor variations, although there is much that is still not understood about these processes. The main unresolved issues in the area of the absorption and transport of long-chain polyunsaturated n-3 fatty acids appear to be: 1) If they, when located in the 2-position of triglycerides, have unique metabolic pathways; and 2) whether the unnatural forms, i.e., methyl or ethyl ester derivatives, are suitable vehicles for administration as dietary supplements. The effect in man of dietary, long-chain polyunsaturated n-3 fatty acids on blood serum lipid and lipoprotein levels, particularly the low density lipoproteins, remains controversial, except for the well-documented reduction in serum triglyceride levels. Also, there is uncertainty regarding their distribution and metabolism in tissues. Finally, if the consumption of long-chain polyunsaturated n-3 fatty acids has beneficial health consequences, what is the appropriate therapeutic dose? In view of these important, unresolved issues and uncertainties, it would seem prudent to direct additional research toward a better understanding of the overall process by which fat is digested, absorbed and transported.

show abstract

“…Currently most environmental exposure to mercury is to low level organic mercury through diet. The principle contemporary dietary source of organic mercury being fish [Clarkson and Magos, 2006], but fish also contain high levels of n-3 PUFAs [Tolan et al , 1972;van Gent et al , 1979;Gebauer et al , 2006]. However regardless of the source, ingested organic Hg is rapidly metabolized to Hg 2+ .…”

Section: Discussionmentioning

confidence: 99%

Dietary n-3 PUFAs augment caspase 8 activation in Staphylococcal aureus enterotoxin B stimulated T-cells

Gill

Jen

McCabe

et al. 2016

Toxicology and Applied Pharmacology

View full text Add to dashboard Cite

Epidemiological studies have linked consumption of n-3 PUFAs with a variety of beneficial health benefits, particularly with respect to putative anti-inflammatory effects. Unfortunately, many of these results remain somewhat controversial because in most instances there has not been a linkage to specific molecular mechanisms. For instance, dietary exposure to low levels of mercury has been shown to be damaging to neural development, but concomitant ingestion of n-3 PUFAs as occurs during consumption of fish, has been shown to counteract the detrimental effects. As the mechanisms mediating the neurotoxicity of environmental mercury are not fully delineated, it is difficult to conceptualize a testable molecular mechanism explaining how n-3 PUFAs negate its neurotoxic effects. However, environmental exposure to mercury also has been linked to increased autoimmunty. By way of a molecular understanding of this immuno-toxic association, disruption of CD95 signaling is well established as a triggering factor for autoimmunity, and we have previously shown that environmentally relevant in vitro and dietary exposures to mercury interfere with CD95 signaling. In particular we have shown that activation of caspase 8, as well as downstream activation of caspase 3, in response to CD95 agonist stimulation is depressed by mercury. More recently we have shown in vitro that the n-3 PUFA docosahexaenoic acid counteracts the negative effect of mercury on CD95 signaling by restoring caspase activity. We hypothesized that concomitant ingestion of n-3 PUFAs with mercury might be protective from the immuno-toxic effects of mercury, as it is with mercury’s neuro-toxic effects, and in the case of immuno-toxicity this would be related to restoration of CD95 signal strength. We now show that dietary ingestion of n-3 PUFAs generally promotes CD95 signaling by upregulating caspase 8 activation. Apart from accounting for the ability of n-3 PUFAs to specifically counteract autoimmune sequelae of mercury exposure, this novel finding for the first time suggests a testable molecular mechanism explaining the overall anti-inflammatory properties of n-3 PUFAs.

show abstract

Effect, on Serum Lipid Levels of Ω-3 Fatty Acids, of Ingesting Fish-Oil Concentrate

Cited by 33 publications

References 7 publications

Preparation of an ω3 fatty acid concentrate from cod liver oil

Preparation of an ω3 fatty acid concentrate from cod liver oil

Absorption and transport of fat in mammals with emphasis on n−3 polyunsaturated fatty acids

Dietary n-3 PUFAs augment caspase 8 activation in Staphylococcal aureus enterotoxin B stimulated T-cells

Contact Info

Product

Resources

About