“…Enantiomerically pure cyanohydrins are important structural units, which can easily be converted into variety of organic intermediates including a-hydroxy acids, a-amino acids, and b-amino alcohols. [1][2][3][4][5][6][7][8] Significant advances have been made for developing efficient catalysts for the synthesis of chiral cyanohydrins [9][10][11][12] using Snapper and Hoveyda's peptide-Al catalysts, 13 Jacobsen's thiourea catalysts, 14 Feng's double-activation, [15][16][17][18][19][20][21][22][23] amino acid salt, 24 and Deng's chiral Lewis base. 25,26 Besides, in search of new methodology, Belokon and North have reported bimetallic Ti(IV) salen complex 27 while Shibasaki and coworkers have used bifunctional catalysts with Ti(IV), 28,29 Gd(O i Pr) 3 , 30 and Sm(O i Pr) 3 31 for the enantioselective cyanosilylation of ketones.…”