Effective and Ineffective Antilymphocyte Sera Correlation of in Vitro Tests with Potency of Early Antisera

Davis, Robert C.; Cooperband, Sidney R.; Mannick, John A.

doi:10.3181/00379727-133-34584

Cited by 5 publications

(2 citation statements)

References 4 publications

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“…In contrast to 15 NRS-treated, parasite-infected controls and 7 uninfected but ATS-treated mice, all surviving the treatment, 3 of 15 parasiteinfected, ATS-treated mice died within a period of 3 weeks. Weight curves demonstrated a clear-cut difference between infected and uninfected animals.…”

Section: Effect Of Ats On Infection With High-virulentmentioning

confidence: 90%

Effect of Antithymocyte Serum on Experimental Toxoplasmosis in Mice

Strannegård¹,

Lycke²

1972

Infect Immun

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The effect of antithymocyte serum (ATS) on mice infected with high-virulent or low-virulent strains of Toxoplasma gondii was studied. Treatment with ATS reduced the survival time of mice infected with high-virulent Toxoplasma and aggravated the disease; treatment prolonged parasitemia in animals infected with low-virulent Toxoplasma. Although ATS adversely affected the humoral antibody response, its main effect on toxoplasmosis was probably due to depression of cellmediated immunity. ATS appeared to be able to activate chronic Toxoplasma infection, but this effect was much less pronounced than that on acquisition of immunity. The results suggest that Toxoplasma irnfection should be routinely looked for in patients treated with antilymphocyte serum.

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Section: Effect Of Ats On Infection With High-virulentmentioning

confidence: 90%

Effect of Antithymocyte Serum on Experimental Toxoplasmosis in Mice

Strannegård¹,

Lycke²

1972

Infect Immun

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“…ATS was prepared in 2 New Zealand White rabbits according to the method of Davis, Cooperband & Mannick (1970). Briefly, 3-week-old male CD-I mice were killed, and the thymus glands removed and disrupted until a single cell suspension was present in RPMI 1640 (GIBCO Laboratories, Grand Island, New York).…”

Section: Anti-thymocyte Serum (Ats) Preparationmentioning

confidence: 99%

Effects of anti-thymocyte serum on the eosinophil and lysophospholipase responses in mice infected withTrichinella spiralis

Adewusi

Goven

1987

Parasitology

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Anti-thymocyte serum (ATS) was administered to CD-1 mice infected with 100 Trichinella spiralis larvae and its effects on intestinal lysophospholipase (EC 3.1.1.5) activity, peripheral blood lymphocytes and bone marrow, peripheral blood and intestinal eosinophilia were assayed in the same experimental animal. The ATS caused a significant suppression of both the tissue lysophospholipase response and eosinophilia, in all three compartments, when compared to the values found in infected mice that were either treated with normal rabbit serum (NRS) or untreated. The suppressed eosinophil response and reduced lysophospholipase activity demonstrated a close temporal relation throughout the experiment. These findings support the hypothesis that helminth parasite-induced eosinophilia is the cause of increased lysophospholipase activity present in parasitized tissue and that the responses are thymus cell dependent.

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