Effective and Selective Extraction of Quercetin from Onion (Allium cepa L.) Skin Waste Using Water Dilutions of Acid-Based Deep Eutectic Solvents

Ciardi, Matteo; Ianni, Federica; Sardella, Roccaldo; Bona, Stefano Di; Cossignani, Lina; Germani, Raimondo; Tiecco, Marcello; Clementi, Catia

doi:10.3390/ma14216465

Cited by 19 publications

(9 citation statements)

References 82 publications

(97 reference statements)

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“…Glycolic acid and trimethylglycine molecules can form a DES when mixed together in 2/1 GA/TMG molar ratio, and this DES has found fruitful applications in chemical transformations, in extraction procedures, in membranes realization [40,[51][52][53][54][55][56][57]. In particular, in the extraction of quercetin from onion skin waste, its 30% w/w water dilution was the best-performing in a screening on various DESs, underlining the water affinity of this solvent [61].…”

Section: Screening Of Molecules For Dess Formation With Watermentioning

confidence: 98%

aquo-DESs: WATER-BASED BINARY NATURAL DEEP EUTECTIC SOLVENTS

Picciolini

Pastore

Giacco

et al. 2023

Preprint

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Deep Eutectic Solvents (DESs) are a class of solvents that are increasing their relevance in the research activity thanks to their environmental-friendly features as well as to their structural characteristics and catalytic properties. Formed by no-solvent mixing of two substances, namely a hydrogen bond donor and a hydrogen bond acceptor, DESs are finding fruitful applications in many different topics as alternatives to common organic compounds. In this work the realization, the characterization and the solubility applications of a novel water- based class of DESs are proposed. These innovative liquids, called aquo-DESs, are binary mixtures of water with glycolic acid (GA) and with trimethylglycine (TMG): GA/H2O (1/4 molar ratio) and TMG/H2O (1/5 molar ratio). The DES identity of these mixtures was demonstrated by: shifts both in terms of the molar fraction and of the melting points in the experimental melting point curves from the theoretical ones; amounts of components over their reported maximum solubility in water; thermogravimetric profiles compared to the pure substances. The aquo-DESs were characterized in their viscosity and ionic conductivity in the temperature range 20-55 C, showing really low viscosity and low ionic conductivity, with a peculiar behavior of the ionic conductivity of GA/H2O DES. The solubilizing properties of aminoacids, phenols and carboxylic acids showed peculiar really high values whenever the solute can participate to the DES as DES component itself.

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Section: Screening Of Molecules For Dess Formation With Watermentioning

confidence: 98%

aquo-DESs: WATER-BASED BINARY NATURAL DEEP EUTECTIC SOLVENTS

Picciolini

Pastore

Giacco

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Various analytical techniques have been developed for the estimation of these compounds, either individually or in combination, from different sources. For instance, high-performance liquid chromatography (HPLC) and UFLC methods have been established for the estimation of Quercetin [16][17][18][19][20][21][22], whereas HPLC and HPTLC techniques have been used for the estimation of Berberine [23][24][25][26][27][28][29][30][31][32][33][34], alone or in combination. Similarly, HPLC methods have been utilized for the quantification of Phytosterols [35][36][37][38][39].…”

Section: Introductionmentioning

confidence: 99%

LC method for the quantification of Quercetin, Berberine, and Phytosterol in lyophilized liposome

Bhavsar,

Jha,

Patel

et al. 2023

Separation Science Plus

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The objective of this study was to create a liquid chromatographic method that could accurately and simultaneously quantify the amount of Quercetin, Berberine, and Phytosterol present in lyophilized liposome used to treat metabolic syndrome. To achieve this goal, the team utilized a Shim‐pack GIST C8 column with a gradient elution of 0.1% (V/V) triethylamine buffer: acetonitrile at 30°C. They analyzed the phytoconstituents using an eluent flow rate of 1 mL/min and ultraviolet detection at 205 nm. The method was linear within a range of 25–77 μg/mL, which had excellent correlation coefficients (R2) of 0.9998, 0.9998, and 0.9996 for Quercetin, Berberine, and Phytosterol, respectively. The %RSD for precision and robustness of the method were also less than 2%, and the recovery values for Quercetin, Berberine, and Phytosterol were 99.5%, 100.5%, and 99.8%, respectively. The assay values of were found to be 100.2%, 101.6%, and 100.5% for Quercetin, Berberine, and Phytosterol, loaded lyophilized liposomes, respectively. As a result, this specific, accurate, and precise method can be employed for the routine analysis of Quercetin, Berberine, and Phytosterols in QC laboratories.

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“…Green tea infusions and bitterness are due to poly phenols were investigated8. Deep Eutectic Solvents (DESs) gives high yield for extraction of QRN and its glycosylated form from onion peels 9 . Phenolic compounds have antioxidant, antimutagenic, anticarcinogenic, anti-inflammatory, and antimicrobial activities 10 .…”

Section: Introductionmentioning

confidence: 99%

Assessment of Quercetin Content in Selected Vegetables and Fruits by Conventional Extraction and High Performance Liquid Chromatography

Swathi

Venugopal

2022

Orient. J. Chem

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One of the dietary flavonoids which can be found in a variety of vegetables and fruits is Quercetin (3,3′,4,5,7-pentahydroxyflavone).Quercetin reduce infection risk and also has unique biological property which improves the physical performance. The current research work describes the extraction and characteristic of quercetin present in carrot (Daucus carota sp. sativus) and grapes (genus vitis). A liquid – solid extraction method of quercetin contained in carrot and grapes was developed, in which Quercetin is extracted from a solid mixture using a liquid solvent (methanol). Determination of Quercetin is studied by using High performance liquid chromatography. The separation study was performed on Zodiac C18, 250mmx 4.6mm, 5µm column, detection at 280nm and flow rate applied 1mL/min. The limits of detection(LOD) and quantification(LOQ) parameters were in the ranges of 0.1–0.3 and 0.3–1.0 μ g/ mL respectively. The results of carrot and grape meet the specified specification limit. The detection of the active substance in carrot and grapes using the HPLC method has the advantage of being simple, fast, and accurate and the reported method was validated.

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Effective and Selective Extraction of Quercetin from Onion (Allium cepa L.) Skin Waste Using Water Dilutions of Acid-Based Deep Eutectic Solvents

Cited by 19 publications

References 82 publications

aquo-DESs: WATER-BASED BINARY NATURAL DEEP EUTECTIC SOLVENTS

aquo-DESs: WATER-BASED BINARY NATURAL DEEP EUTECTIC SOLVENTS

LC method for the quantification of Quercetin, Berberine, and Phytosterol in lyophilized liposome

Assessment of Quercetin Content in Selected Vegetables and Fruits by Conventional Extraction and High Performance Liquid Chromatography

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