Effective biomodulation by leucovorin of high-dose infusion fluorouracil given as a weekly 24-hour infusion: results of a randomized trial in patients with advanced colorectal cancer.

Abstract

Response rate, TTP, and overall survival were superior for LV-containing regimens compared with IFN modulation alone. The addition of IFN to high-dose infusional FU plus LV offers no advantage and may increase toxicity. The regimen of high-dose infusional FU24h/LV warrants further evaluation in patients with metastatic colorectal cancer.

Alpha-interferon does not increase the efficacy of 5-fluorouracil in advanced colorectal cancer

“…Bolus 5FU were administered in 5 comparisons (Hill et al, 1995;Dufour et al, 1996;Greco et al, 1996;Piga et al, 1996;Palmeri et al, 1998) and continuous infusion 5FU in one comparison (Hill et al, 1995b). The comparison of 5FU + LV versus 5FU + LV + α-IFN was addressed in 6 trials, the Gruppo Oncologico dell'Italia Meridionale (GOIM) trial (Colucci et al, 1999), the Roma trial (Cassano et al, 1996), the trial from Hungary (Pajkos et al, 1997), the trial from Argentina (Pensel et al, 1993), the Medical Research Council (MRC) trial (Seymour et al, 1996), and the AIO trial (Köhne et al, 1998). The AIO trial (Köhne et al, 1998) and the trial from Hungary (Pajkos et al, 1997) were multiple-arm trials.…”

“…The comparison of 5FU + LV versus 5FU + LV + α-IFN was addressed in 6 trials, the Gruppo Oncologico dell'Italia Meridionale (GOIM) trial (Colucci et al, 1999), the Roma trial (Cassano et al, 1996), the trial from Hungary (Pajkos et al, 1997), the trial from Argentina (Pensel et al, 1993), the Medical Research Council (MRC) trial (Seymour et al, 1996), and the AIO trial (Köhne et al, 1998). The AIO trial (Köhne et al, 1998) and the trial from Hungary (Pajkos et al, 1997) were multiple-arm trials. Two trials (MRC (Seymour et al, 1996), AIO (Köhne et al, 1998)) used a continuous infusion 5FU.…”

“…The AIO trial (Köhne et al, 1998) and the trial from Hungary (Pajkos et al, 1997) were multiple-arm trials. Two trials (MRC (Seymour et al, 1996), AIO (Köhne et al, 1998)) used a continuous infusion 5FU. Trials were stratified according to 5FU schedule of administration (5FU bolus and 5FU continuous infusion), and in terms of modulation of 5FU by leucovorin.…”

“…Meta-analysis of 5FU + LV vs. 5FU + α-IFN (Table 2) The comparison of 5FU + LV versus 5FU + α-IFN was addressed in 7 trials, the Corfu-A trial (Corfu-A Study Group, 1995), the GOIRC trial (Di Costanzo et al, 1995), the Yale trial (Marsh et al,), the trial from Turkey (Aykan et al, 1996), the ECOG/CALGB trial (O'Dwyer et al, 1996), the AIO trial (Köhne et al, 1998), the trial Hungary (Pajkos et al, 1997). Three of these trials (O'Dwyer et al, 1996;Pajkos et al, 1997;Köhne et al, 1998) were multiple-arms trials.…”

“…Three of these trials (O'Dwyer et al, 1996;Pajkos et al, 1997;Köhne et al, 1998) were multiple-arms trials.…”