However, the following challenges still have to face, like the demanding materials (ultralonger nanowires, [15] ultrathin carbon nanotube/graphene film, [2] conducting polymer with special microstructure, [4] etc.), the fabrication of complicated structures based on micro/nano-electromechanical system technologies, [16] the challenging upscaling Si manufacturing processes, [17] strongly instrument dependence, [18] and not environmental friendly. [19] More important, these developed pressure sensors are mainly focused on sensitivity. [20,21] During practical application, they still need to be used with heavy equipment through cable for data delivery. Thereby, how to detect human pulse signals in a facile way and further to convey the perceived data to terminal devices with battery-less (or free) is very interesting for wearable electronic system.Radio frequency (RF) technology is one kind of wireless information transmission approach and a radio frequency antenna is its critical component. In this way, power will be transmitted from the sender coil to the receiver coil of the object by electromagnetic induction, and the relevant data information of the object will be received by the sender coil through the same principle. Up to now, it also has been applied to radio frequency identification, [22] transistor, [23] sensor, [24] actuator [25] in the traditional silicon and plastic electronics. But, the field of wearable RF sensor is still in its infancy. Like other emerging electronic technologies, both new materials and processing methods are the main driving forces for their everimproving development and performance.Herein, we report a new kind of flexible wireless pressuresensing device based on a chip-type ionic alginate hydrogel (IAH) microsphere, including (i) to synthesize a highly sensitive IAH microsphere as sensing component and to be sandwiched by a folded polyethylene terephthalate (PET) film with continuous silver patterns as both antenna and electrode through a stack of double-sided tape as bonding frame; (ii) to explain the sensing mechanism of the prepared wireless sensor system through a series of theories, which are very important to clarify the working mechanism and provide a significant guidance for this device design and preparation; and (iii) to further optimize the performance of the prepared flexible pressure sensor through the diameters of electrode sensing area, bending angles, and the antenna configurations. Its efficiency Flexible pressure-sensing systems have attracted more attention recently. Here, a novel kind of flexible wireless pressure-sensing device is reported based on a chip-type ionic alginate hydrogel (IAH) microsphere, which is sandwiched by a folded polyethylene terephthalate film with a continuous silver pattern as both antenna and electrode through a stack of double-sided tape as bonding frame. The whole device can be seen as an inductance (L)/capacitance (C)/resistance (R) (LCR) oscillation circuit and the main sensing mechanism is based on the variation of contact electri...