“…As the purity of flavonoids from plants is reportedly positively related to their biological activities [ 13 ], it is crucial to establish an efficient method to improve flavonoids purity. At present, many techniques for the enrichment of flavonoids are inefficient and not suitable for large-scale industrial production as they are time- and solvent-consuming, such as ultrafiltration, supercritical fluid extraction, high-speed counter-current chromatography [ 14 ], aqueous two-phase extraction [ 15 ], molecularly imprinted membrane [ 16 ] and preparative HPLC [ 17 , 18 , 19 ]. Because of their relative ideal pore structure, various polarity ranges, high efficiency, environmental friendliness, energy conservation and easy operation, macroporous resins are widely used in flavonoids enrichment from many crude extracts of natural resources such as Pteris ensiformis Burm.…”