Effective protection of Terminalia catappa L. leaves from damage induced by carbon tetrachloride in liver mitochondria

Tang, Xin; Gao, Jing; Wang, Yanping; Fan, Yida; Xu, Lizhi; Zhao, Xiaoning; Xu, Qiang; Qian, Zhong Ming

doi:10.1016/j.jnutbio.2005.06.008

Cited by 63 publications

(45 citation statements)

References 20 publications

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“…Intoxication of CCL 4 also results in inhibition of the synthesis of the bile acids from the cholesterol and leads to elevated level of cholesterol [20] . Suppression of cholesterol level in the serum parameters suggests the inhibition of synthesis of the bile acids from cholesterol, and is reversed by the pre-administration of the L. racemosa leaf extract [21] . Reduction in the level of SGOT, SGPT towards the normal value is an indication of the stabilization of the plasma membrane as well as repair of hepatic tissue damage caused by CCL 4 [22] .…”

Section: Discussionmentioning

confidence: 98%

Hepatoprotective and antioxidant activity of a mangrove plant Lumnitzera racemosa

Sundaram

Gnanadesigan

2011

Asian Pacific Journal of Tropical Biomedicine

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Section: Discussionmentioning

confidence: 98%

Hepatoprotective and antioxidant activity of a mangrove plant Lumnitzera racemosa

Sundaram

Gnanadesigan

2011

Asian Pacific Journal of Tropical Biomedicine

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“…Serum levels of AST and ALT are the quite sensitivity indicators to evaluate the degree of hepatic damage. The level of AST is an indicator of mitochondrial damage, because mitochondria contain 80% of the enzyme (Tang et al 2006). The increase of AST indicates that the mitochondria were destroyed.…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective effect of a protein-enriched fraction from the maggots (Musca domestica) against CCl4-induced hepatic damage in rats

Wang

Chen

et al. 2007

Biotechnol Lett

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The hepatoprotective potential of a protein-enriched fraction (PEF) isolated from the maggots of housefly (Musca domestica) was evaluated in rats against carbon tetrachloride (CCl4)-induced acute hepatic damage. Activities of serum aspartate aminotransferase and alanine aminotransferase increased by 4- and 13-fold induced by CCl4, were significantly inhibited by pretreatment with 50, 100 and 200 mg PEF/kg. The formation of malondialdehyde was also significantly decreased in PEF-treated group compared with CCl4-treated group. The treatments with PEF also elevated total protein levels significantly. These results were further supplemented by histopathological examination of liver sections. Hyperplasia of kupffer cells was observed after treatment with PEF (100 and 200 mg/kg). We conclude that PEF is effective in this model of liver damage.

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“…The inner and outer membranes of mitochondria contain unsaturated lipids and they are susceptible to free radicals attack [36]. The mitochondrial dysfunction during aluminium sulphate toxicity resulted from the declined activities of TCA enzymes and respiratory chain complexes, which are ascribed to the ROS generated by ccl4 [37]. In this study, the activities of the major TCA enzymes such as ICDH, α-KGDH, SDH and MDH were declined significantly in the aluminium sulphate control compared with that of normal rats.…”

Section: Discussionmentioning

confidence: 52%

Efficacy of Wattakaka Volubilis Against Aluminium Sulphate Induced in Liver Toxicity

S¹,

Ray²

2018

Int J Pharm Pharm Sci

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Objective: The modulation of membrane-bound ATPases, carbohydrate metabolizing enzymes and mitochondrial TCA cycle enzymes in Wattakaka volubilis on aluminium sulphate induced liver toxicity. Methods:Medicinal therapy requires careful assessment of effective treatment offering an acceptable safety over human health. Experimental animals were divided into five groups (Untreated, negative and positive control, hepatic group and the hepatic group fed on Wattakaka volubilis), Metabolising enzymes level, estimation of DNA, RNA and quantification of DNA fragmentation and gene expression were investigated. These altered enzyme levels were ameliorated significantly by administration of Wattakaka volubilis at the concentration of 200 mg/kg in drug-treated animals. Results:Results showed that treatment with methanol extract of Wattakaka volubilis normal level of enzymes which are compared with silymarin. This was evident from the significant increase in p<0.05, p<0.01, p<0.001 enzyme levels. Aluminium sulphate induced rats showed decreased the activities of metabolising enzymes and increased DNA fragmentation in the liver. This clearly explained the reason for the hepatoprotective activity of Wattakaka volubilis leaf extract. Conclusion:The methanolic leaf extract of W. volubilis showed high protective activity against aluminium sulphate-induced hepatotoxicity.

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Effective protection of Terminalia catappa L. leaves from damage induced by carbon tetrachloride in liver mitochondria

Cited by 63 publications

References 20 publications

Hepatoprotective and antioxidant activity of a mangrove plant Lumnitzera racemosa

Hepatoprotective and antioxidant activity of a mangrove plant Lumnitzera racemosa

Hepatoprotective effect of a protein-enriched fraction from the maggots (Musca domestica) against CCl4-induced hepatic damage in rats

Efficacy of Wattakaka Volubilis Against Aluminium Sulphate Induced in Liver Toxicity

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