Effective Treatment of Hereditary Angioedema with Fresh Frozen Plasma in an Emergency Department

Pekdemir, Murat; Ersel, Murat; Aksay, Ersin; Yanturali, Sedat; Aktürk, Aysun Şikar; Kıyan, Selahattin

doi:10.1016/j.jemermed.2007.02.024

Cited by 34 publications

(18 citation statements)

References 9 publications

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“…Although not approved by the FDA for this indication, fresh frozen plasma (FFP) can be used for HAE, if the more specific therapies are not available (48,49). FFP has also been used for ACEi-AE, and has shown effectiveness (50,51).…”

Section: C1-inhibitor Replacement Therapymentioning

confidence: 99%

Angioedema: Etiology, Pathophysiology, Current and Emerging Therapies

Lewis

2013

The Journal of Emergency Medicine

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Section: C1-inhibitor Replacement Therapymentioning

confidence: 99%

Angioedema: Etiology, Pathophysiology, Current and Emerging Therapies

Lewis

2013

The Journal of Emergency Medicine

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“…Alternatively when this is not available, the use of intravenous fresh frozen plasma has been used effectively. 6,7 Corticosteroids and antihistamines have no effect in limiting the severity of attacks in HAE and should not be used.…”

Section: Case Reportmentioning

confidence: 99%

Hereditary angioedema and pregnancy: successful management of recurrent and frequent attacks of angioedema with C1-inhibitor concentrate, danazol and tranexamic acid – a case report

et al. 2009

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Summary: Hereditary angioedema (HAE) is a rare but potentially life-threatening condition caused by deficiency of C1 esterase inhibitor. It is characterized by subcutaneous swelling in any part of the skin, gastrointestinal and respiratory tracts. We present the case of a pregnant woman with known HAE that deteriorated during pregnancy with frequent attacks that were managed successfully with danazol, tranexamic acid and regular intravenous administration of C1 esterase inhibitor.

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“…Angioedema is localized, rapid-onset, temporary, and often recurrent edema (1,2). It involves the deeper layers of skin; this edema is therefore non-pitting and poorly demarcated.…”

Section: Discussionmentioning

confidence: 99%

“…It is thought to be related to decreased degradation of kinins. Both hereditary and ACE inhibitor-associated angioedema are often refractory to typical therapy with antihistamines, corticosteroids, and epinephrine (2,3). In cases of hereditary angioedema, C1 esterase inhibitor concentrate has been used successfully to treat angioedema (2).…”

Section: Discussionmentioning

confidence: 99%