Effective treatment of liver metastases from colon cancer with a combination of ?-interferon and cisplatin chemotherapy: Report of a case

Abstract

We report herein the case of a 63-year-old man with cancer of the sigmoid colon and metastatic nodules in the liver who was effectively treated with a combination of cisplatin regional chemotherapy, given through the hepatic artery, in conjunction with a 3-week course of intravenous gamma-interferon (INF-gamma), following palliative sigmoidectomy and dissection of the regional lymph nodes. This was followed-up by a 3-month course of oral 5-fluorouracil. Hepatic imaging performed 6 months postoperatively showed no masses in the right hepatic lobe and an apparent decrease in the size of the tumor in the left lobe. A second-look operation with resection performed at this time confirmed the efficacy of the chemotherapy. The patient survived in excess of 30 months following his initial surgery before succumbing to hepatic failure.

Liposome-targeted delivery for highly potent drugs

“…Among them, the ability of targeted anti-mRNA liposomal delivery systems in covering protection of entrapped anti-mRNA formulation from renal clearance and nuclease degradation besides providing efficient cellular uptake and endosomal escape is of utmost importance (Gandhi et al 2014, Pereira et al 2013). Tumor immunotherapy [Park et al 2012] c-Interferon (INF-c) Cisplatin Cancer of the sigmoid colon and metastatic nodules in the liver [Kohara et al 1995] Tumor necrosis factor-a (TNF) Liposomal DOX Soft-tissue sarcoma [Ten Hagen et al 2002] IL-2 -Hepatic metastases [Kanaoka et al 2002] Calcitonin -Assessment of mucoadhesive function for oral administration [Takeuchi et al 2003] Vasoactive intestinal peptide (VIP) -Chronic ocular pathologies such as autoimmune uveitis [Lajavardi et al 2009] Asialoerythropoietin (AEPO) -Cerebral ischemia-reperfusion (I/R) [Ishii et al 2012] Insulin -Diabetes mellitus-oral route-intestinal route-pulmonary route [Jain et al 2007] [Bi et al 2008 Asai et al have developed tetraethylenepentamine-based polycation liposomes, active targeted with Ala-Pro-Arg-Pro-Gly (APRPG-TEPA-PCL) for the systemic delivery of siRNA used for targeting angiogenic endothelium. Intravenous injection of APRPG-TEPA-PCL into Colon26 NL-17 carcinoma-bearing mice have showed liposome accumulation in the tumor, which have confirmed APRPG-PEG conjugation to liposome and it was a useful strategy for both drug-and gene-targeted delivery to angiogenic vessels in tumors (Asai et al 2011).…”

Interferon-gamma (IFN-γ) as a potential radio- and chemo-protectant

“…These varied anti-tumor activities of interferons have led to the use of interferon-gamma (IFN-␥) in a number of clinical settings, and with widely disparate results. It has been used in combination with chemotherapeutic agents in the treatment of colon, small cell lung and metastatic renal cell carcinoma, high-risk cutaneous melanoma, as well as chronic myelogenous leukemia [6][7][8][9][10][11][12]. Because of the demonstrated potentiation of radiation's antiproliferative effects, it has also been given together with radiation in an effort to improve radiation's efficacy in other tumors [13,14].…”

Interferon‐gamma (IFN‐γ) as a potential radio‐ and chemo‐protectant

“…It has been used in combination with chemotherapeutic agents in the treatment of colon, small cell lung and metastatic renal cell carcinoma, high-risk cutaneous melanoma, as well as chronic myelogenous leukemia [6][7][8][9][10][11][12]. It has been used in combination with chemotherapeutic agents in the treatment of colon, small cell lung and metastatic renal cell carcinoma, high-risk cutaneous melanoma, as well as chronic myelogenous leukemia [6][7][8][9][10][11][12].…”