Effective treatment with photodynamic therapy of cutaneous leishmaniasis: A case report

Johansen, Mila Broby; Jemec, Gregor B. E.; Fabricius, Susanne

doi:10.1111/dth.13022

Cited by 21 publications

(24 citation statements)

References 15 publications

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“…The ulcero-crusted form of CL was found to be more frequent (105; 73.7%), followed by the papulonodular form (30; 21.1%), and lastly the impetigenous form (7; 5.2%) (Table -5). These results are in agreement with those reported by previous studies [25,26]. The latter study found that the ulcerated form has the most common presentation.…”

Section: Resultssupporting

confidence: 94%

Evaluation of the Surveillance and Epidemiological Aspects of Cutaneous Leishmaniasis in Babylon Province, Iraq

Al-Obaidi

Ali

2021

eijs

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Leishmaniasis diseases constitute an important public health problem in both tropical and subtropical areas. The aim of this study is to evaluate the epidemiological situation of cutaneous leishmaniasis (CL) in Babylon province, Iraq. The current work included the recording of 142 new cases of CL infection in Babylon province for the period from November 2019 to February 2020. Male infection was represented by 87 cases (61.27%), while females composed 55 samples (38.73%), with a significant difference (p<0.05) between the two groups. The age group of 5-14 years was found to have the highest recorded CL cases (56; 39.44%), while the age group of less than one year had the lowest cases (1; 0.70%), with the differences being significant at p<0.05. Al-Gazali location was found to include the highest recorded CL cases (29; 20.42%), whereas Kish location had the lowest cases (1; 0.70%). The dry type of CL lesions was represented in 112 cases (78.9%), while the wet type was represented 30 cases (21.1%). The ulcero-crusted form of CL sores was more frequent (105; 73.7%), followed by the papulonodular form (30; 21.1%). According to the location of lesions, the upper limb lesions were more frequent (90; 63.16%), followed by the lower limb lesions (37; 26.32%). About 82 (57.9%) of the recorded CL cases were appearing as new cases, whereas 60 cases (42.1%) were recorded as a relapse after treatment. The study concludes that CL is highly distributed in Babylon province.

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Section: Resultssupporting

confidence: 94%

Evaluation of the Surveillance and Epidemiological Aspects of Cutaneous Leishmaniasis in Babylon Province, Iraq

Al-Obaidi

Ali

2021

eijs

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“…The use of PDT as an alternative therapeutic approach was justified by several reports that demonstrated some success in treating superficial CL. [9][10][11] In the present case, after initial failure of firstline liposomal amphotericin B therapy, sensitized PDT alone did not cure the condition. However, the first sessions of PDT resulted in significant reduction in size of the lesion, possibly due to the 7-day association with posaconazole.…”

Section: Discussioncontrasting

confidence: 55%

Cutaneous leishmaniasis due to Leishmania aethiopica: A therapeutic challenge

Mengeot¹,

Yombi²,

Baeck³

2022

JAAD Case Reports

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“…He was previously resistant to pentavalent antimony, oral fluconazole and local ketoconazole. His ulcer healed completely after repeated ALA-PDT ( Figure 6 ) ( 115 ). Compared with systemic therapy, this method should be considered as an attractive antiparasitic treatment, especially for drug-resistant cases.…”

Section: The Effects Of the Photosensitizer-based Therapies On Human ...mentioning

confidence: 99%

The photosensitizer-based therapies enhance the repairing of skin wounds

Ning

Zeng

et al. 2022

Front. Med.

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Wound repair remains a clinical challenge and bacterial infection is a common complication that may significantly delay healing. Therefore, proper and effective wound management is essential. The photosensitizer-based therapies mainly stimulate the photosensitizer to generate reactive oxygen species through appropriate excitation source irradiation, thereby killing pathogenic microorganisms. Moreover, they initiate local immune responses by inducing the recruitment of immune cells as well as the production of proinflammatory cytokines. In addition, these therapies can stimulate the proliferation, migration and differentiation of skin resident cells, and improve the deposition of extracellular matrix; subsequently, they promote the re-epithelialization, angiogenesis, and tissue remodeling. Studies in multiple animal models and human skin wounds have proved that the superior sterilization property and biological effects of photosensitizer-based therapies during different stages of wound repair. In this review, we summarize the recent advances in photosensitizer-based therapies for enhancing tissue regeneration, and suggest more effective therapeutics for patients with skin wounds.

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Effective treatment with photodynamic therapy of cutaneous leishmaniasis: A case report

Cited by 21 publications

References 15 publications

Evaluation of the Surveillance and Epidemiological Aspects of Cutaneous Leishmaniasis in Babylon Province, Iraq

Evaluation of the Surveillance and Epidemiological Aspects of Cutaneous Leishmaniasis in Babylon Province, Iraq

Cutaneous leishmaniasis due to Leishmania aethiopica: A therapeutic challenge

The photosensitizer-based therapies enhance the repairing of skin wounds

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