Effective Wound Closure With a New Two-Component Wound Closure Device (Prineo™) in Excisional Body-Contouring Surgery: Experience in Over 200 Procedures

Abstract

Background In excisional body-contouring surgery the surgeon is often confronted with time-consuming closure of long wounds. Recently, a new combination of a selfadhering mesh together with a liquid 2-octyl cyanoacrylate adhesive (Prineo TM ; Ethicon, Inc., Somerville, NJ, USA) has been introduced to replace intracutaneous running suture. Methods An observational study was undertaken to evaluate the efficacy of the new wound closure device in excisional body-contouring procedures between January 2008 and November 2010. Wound characteristics were recorded in a prospectively maintained database. Results During the study period, 224 procedures in 180 patients were undertaken. Twenty-seven patients had two subsequent operations and four patients had three subsequent operations. Application of the new device was easy and safe and patient satisfaction with the results was generally high. However, intense local allergic reactions were seen in 4 patients (1.8%), which necessitated early removal and topical corticosteroid treatment. Conclusions Prineo TM enables the surgeon to perform a quick and smooth skin closure, especially in long incisions frequently encountered in excisional body-contouring surgery. The application is fast and easy if basic guidelines are respected. Operating time is saved by eliminating the need for time-consuming intracutaneous running sutures. Removal is easy and painless for the patient. However, there is a potential for local allergic adverse effects of which the surgeon must be aware.

Hemostats, sealants, and adhesives III: a new update as well as cost and regulatory considerations for components of the surgical toolbox

“…In a recent prospective single‐center prospectively maintained database, this product was found to be especially useful in longer incisions such as those associated with body contouring reducing the time required to place lengthy, running, intracutaneous sutures 53 . Several allergic reactions were seen in 1.8% (4/224) and required removal of the system and application of corticosteroid cream.…”

Allergic contact dermatitis after using Prineo: Case Report and Review of Literature

“…This product reduces the time necessary for wound closure, better approximates edges, and effectively distributes wound tension. 1 There have been several reports of allergic contact dermatitis after use of octyl-2-cyanoacrylate 2-10 and two reports of a reaction after use of octyl-2-cyanoacrylate with mesh 1,11 .We report our expe A 56-year-old woman with left breast cancer underwent mastectomy and presented for delayed breast reconstruction after chemotherapy and radiation. She underwent left breast reconstruction with a left latissimus dorsi flap and tissue expander without complication.…”

“…1,11 Of these patients, 4 had confirmed previous exposure to octyl-2-cyanoacrylate with mesh that could have sensitized them for reaction in subsequent encounters. Three randomized control trials of 222 patients have not reported any allergic reactions after using octyl-2-cyanoacrylate with mesh.…”

Biomechanical properties of celiotomy wounds closed with tape and cyanoacrylate versus intradermal sutures

“…As a result, wounds closed with this mesh reached a higher holding strength than wounds closed with skin staples and subcuticular sutures in an ex vivo study on porcine skin . Previous clinical studies on MOC have established its safety, effectiveness, speed of application, and good cosmetic results compared with intradermal sutures when applied to sparsely haired regions in man . To the best of the authors’ knowledge, the biomechanical properties of surgically created wounds closed by MOC have not been described in dogs.…”

“…8 Previous clinical studies on MOC have established its safety, effectiveness, speed of application, and good cosmetic results compared with intradermal sutures when applied to sparsely haired regions in man. [9][10][11][12] To the best of the authors' knowledge, the biomechanical properties of surgically created wounds closed by MOC have not been described in dogs.…”