Effectiveness and Safety of Chinese Medicine Combined with Omeprazole in the Treatment of Gastric Ulcer：A protocol for systematic review and meta-analysis

Xie, Changsheng; Liu, Langhui; Zhu, Suyou; Wei, Mingquan

doi:10.37766/inplasy2021.4.0048

2021

DOI: 10.37766/inplasy2021.4.0048

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Effectiveness and Safety of Chinese Medicine Combined with Omeprazole in the Treatment of Gastric Ulcer：A protocol for systematic review and meta-analysis

Changsheng Xie¹,

Langhui Liu²,

Suyou Zhu³

et al.

Abstract: Review question / Objective: In order to further clarify its clinical application value, t h i s s t u d y a d o p t s t h e m e t h o d s o f systematic review andMeta analysis to comprehensively evaluate the effectiveness and safety of traditional Chinese medicine combined with omeprazole in the treatment of GU, and provide evidence-based basis for its rational use in clinical practice. Condition being studied: Gastric ulcer (GU) is a chronic digestive system disease with a high clinical incidence and recurr… Show more

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Therapeutic Versus Preventative Use of Ginkgo biloba Extract (EGb 761) against Indomethacin-Induced Gastric Ulcer in Mice

et al. 2022

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The main bioactive constituents in the standardized Ginkgo biloba leaf extract (EGb 761) are the terpene lactones and flavonoid glycosides. EGb 761’s antioxidant and anti-inflammatory properties have previously been demonstrated. Indomethacin-induced gastric ulcers have a multifactorial etiology and represent a major restriction to its therapeutic utility. The underlying ulcerogenic process involves oxidative and inflammatory biomolecular insults. This study was performed to explore the curative and preventative benefits of EGb 761 in experimentally-induced ulcers. To develop gastric ulcers in mice, indomethacin (40 mg/kg) was administered orally. EGb 761 (200 mg/kg) was given by gavage for 7 days before (preventative) and after (therapeutic) indomethacin administration. The histological alterations and macroscopic mucosal lesions were assessed. In gastric tissue homogenates, malondialdehyde (MDA), reduced glutathione (GSH), nitric oxide (NO), and inflammatory cytokines were measured. The expressions of cyclooxygenase-2 (COX-2), cytokines, and proliferating cell nuclear antigen (PCNA) in the stomach mucosa were also investigated. The ulcer index, histological alterations, gastric oxidants, and inflammatory biomarkers were all significantly increased by indomethacin. In stomach specimens, it increased COX-2 and PCNA expression. EGb 761 treatments, both prophylactic and therapeutic, resulted in significant reductions in ulcer lesions, nitrosative and oxidative damage, and inflammatory markers, along with the lowering of COX-2 and PCNA expressions. Furthermore, in the fight against stomach ulcers, EGb 761 treatment was found to be more efficient than prevention.

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Therapeutic Versus Preventative Use of Ginkgo biloba Extract (EGb 761) against Indomethacin-Induced Gastric Ulcer in Mice

et al. 2022

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Advancements in Solubility Enhancement of Omeprazole: A Comprehensive Review

Mulla,

Nemade,

Ansari

et al. 2024

RJPDFT

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Omeprazole, a widely prescribed proton pump inhibitor renowned for its effectiveness in treating gastrointestinal disorders, faces limitations in its therapeutic potential due to its poor aqueous solubility, resulting in suboptimal bioavailability. This article conducts a thorough review of recent advancements in strategies aimed at enhancing omeprazole's solubility. The evaluation encompasses various techniques, including solid dispersion technology, nanosizing, cyclodextrin complexation, salt formation, and micellar delivery systems, all aimed at improving the solubility and overall therapeutic performance of omeprazole. The review addresses existing challenges and outlines future prospects, with a specific focus on the translation of solubility enhancement strategies from laboratory settings to commercial production. The comprehensive insights presented contribute to a profound understanding of the recent advancements in solubility enhancement of omeprazole, fostering the development of more efficient and patient-friendly formulations for improved therapeutic outcomes.

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Effectiveness and Safety of Chinese Medicine Combined with Omeprazole in the Treatment of Gastric Ulcer：A protocol for systematic review and meta-analysis

Cited by 2 publications

References 0 publications

Therapeutic Versus Preventative Use of Ginkgo biloba Extract (EGb 761) against Indomethacin-Induced Gastric Ulcer in Mice

Therapeutic Versus Preventative Use of Ginkgo biloba Extract (EGb 761) against Indomethacin-Induced Gastric Ulcer in Mice

Advancements in Solubility Enhancement of Omeprazole: A Comprehensive Review

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