Effectiveness and safety of iodopovidone in an experimental pleurodesis model

Abstract

OBJECTIVES:Chemical pleurodesis is an important therapeutic tool to control recurrent malignant pleural effusion. Among the various sclerosing agents, iodopovidone is considered effective and safe. However, in a recent study, ocular changes were described after iodopovidone was used in recurrent pneumothorax. The aim of the study was to evaluate the efficacy and morbidity of iodopovidone pleurodesis in an experimental model.METHODS:New Zealand rabbits were submitted to intrapleural injection of iodopovidone at concentrations of 2%, 4% and 10%. Biochemical (lactic dehydrogenase, proteins, triiodothyronine, free thyroxine, urea and creatinine) and immunological (Interleukin-8 [IL-8], VEGF and TGFβ) parameters were measured in the pleural fluid and blood. After 1, 3, 7, 14 and 28 days, groups of animals were euthanized, and macro- (pleura) and microscopic (pleura and retina) analyses were performed.RESULTS:An early pleural inflammatory response with low systemic repercussion was observed without corresponding changes in thyroid or renal function. The higher concentrations (4% and 10%) correlated with greater initial exudation, and maximum pleural thickening was observed after 28 days. No changes were observed in the retinal pigment epithelium of the rabbits.CONCLUSION:Iodopovidone is considered to be an effective and safe sclerosing agent in this animal model. However, its efficacy, tolerance and safety in humans should be further evaluated.

The effects of aqueous extract of babassu (Orbignya phalerata) on the pleura and lung parenchyma in rats

“…The findings of babassu action on the pleural cavity differ to other substances in which the majority of rats exhibited slight adhesions, as well as acute and mild inflammatory changes macroscopically at study endpoint 24 .…”

The efficacy of hydrogel foams in talc Pleurodesis

“…The animal model is based on a well-described rabbit model of pleural adhesions [4,8]. Briefly, New Zealand white male rabbits weighing 2.0 to 3.0 kg were utilized.…”

“…The degree of pleurodesis was evaluated according to an established scoring system by a blinded pathologist and graded: 0: normal pleural space; 1: one to three small adhesions in the pleural space; 2: more than three scattered adhesions with lung easily separated from the chest wall; 3: generalized scattered adhesions with areas where the lung can be separated from the chest wall only with difficulty; and 4: complete obliteration of the pleural space ( Fig. 1) [8].…”

Perfil biomolecular do derrame pleural maligno experimentalmente induzido: frequência de mutações e impacto de terapias-alvo

“…[89][90][91][92][93][94][95] Pela ausência de doença maligna, a avaliação da evolução natural do câncer de pulmão, da interação neoplasia-hospedeiro, da resposta imunológica ou de possíveis terapias era expeculativa. [89][90][91][92][93][94][95] Já com os modelos experimentais de neoplasia pleural, foi possível mimetizar a condição humana, com significativos avanços na compreensão da patogênese do adenocarcinoma de pulmão, dos mecanismos de formação do derrame pleural maligno decorrente do câncer de pulmão, da disseminação do tumor e de possíveis terapias-alvo. [23][24][25][26][27][28] Vários mediadores foram estudados, como o VEGF, por exemplo.…”