EFFECTIVENESS AND TOXICITY DIFFERENCES BETWEEN THE USE OF REGIMEN CHEMOTHERAPY BLEOMYCIN-VINCRISTINE-MITOMYCIN-CISPLATIN AND BLEOMYCIN- VINCRISTINE-MITOMYCIN-CARBOPLATIN FOR THREE CYCLES IN PATIENTS CERVICAL CANCER SQUAMOUS CELL STADIUM IIB-IIIB IN SANGLAH GENERAL HOSPITAL DENPASAR BALI Research Article

Abstract

Objectives: Medicines in the market need their security and their effectiveness monitored to ensure patient safety, which is called Clinical Testing Stage IV. Cytotoxic medicines especially those for cervical cancer chemotherapy, particularly need to be monitored. These medicines include two combinations: Bleomycin-vincristine-mitomycin-cisplatin (BOM-cisplatin) and bleomycin-vincristine-mitomycin-carboplatin (BOM-carboplatin). Both these combinations are commonly used for cervical cancer treatments in Sanglah General Hospital. Up till now, there has not been adequate data to differentiate between the two combinations. Therefore, we conducted the research to explore the relative effectiveness and toxicity of both combinations. The assessment of both combinations can be seen using parameter squamous cell carcinoma (SCC) and tumor-mass. Toxicity assessment of the chemotherapy can be seen by judging functions of the liver (serum glutamic oxaloacetic transaminase [SGOT], serum glutamic pyruvic transaminase [SGPT]), kidneys (blood urea nitrogen [BUN], creatinine), and blood (leukocytes, hemoglobin) of patients. Methods:The observational research with the cross-sectional method in Obstetrics and Gynecology Clinics in Sanglah General Hospital Denpasar Bali. Research on both combinations was carried out between 2013 and 2015. The samples were obtained before the 1 st chemotherapy and after the 3 rd chemotherapy, by using consecutive sampling method. Prodia Clinical Laboratory carried out examinations on levels of SCC, while tumor-mass and the other parameters were carried out by Clinical Pathology Laboratory Sanglah General Hospital. Data were analyzed with the paired t-test with 95% confidence interval, using SPSS 17.0 for Windows.

Evaluasi Serum Kreatinin Dan Blood Urea Nitrogen Pasien Kanker Serviks Yang Menjalani Kemoterapi Paklitaksel-Karboplatin Di Rsup Sanglah Denpasar Tahun 2018

“…Penelitian tersebut menunjukan setelah dilakukan kemoterapi dengan menggunakan cisplatin terjadi peningkatan serum kreatinin dan BUN tetapi pada kemoterapi dengan menggunakan karboplatin tidak terdapat peningkatan serum kreatinin dan BUN tetapi cenderung menurun. 7…”