Effectiveness of 4-hydroxy phenyl N-tert-butylnitrone (4-OHPBN) alone and in combination with other antioxidant drugs in the treatment of acute acoustic trauma in chinchilla

Choi, Chul-Hee; Chen, Kejian; Vasquez-Weldon, Angelica; Jackson, Ronald L.; Floyd, Robert A.; Kopke, Richard D.

doi:10.1016/j.freeradbiomed.2008.02.005

Cited by 62 publications

(76 citation statements)

References 90 publications

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“…PBN and its derivatives have been successfully tried on several rodent models of cancer and seem to be promising [201]. Nitrones seem also to be effective on animal models of hearing loss [202][203][204].…”

Section: Nitronesmentioning

confidence: 99%

Clinical and pharmacological aspects of bath salt use: A review of the literature and case reports

Miotto¹,

Striebel²,

Cho

et al. 2013

Drug and Alcohol Dependence

121

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Abstract:Reactive oxygen species (ROS) are widely believed to cause or aggravate several human pathologies such as neurodegenerative diseases, cancer, stroke and many other ailments. Antioxidants are assumed to counteract the harmful effects of ROS and therefore prevent or treat oxidative stress-related diseases. In this report, recent human studies exploring the efficiency of antioxidants in prevention and treatment of various diseases are reviewed. Few antioxidants including edaravone (for ischemic stroke in Japan), Nacetylcysteine (for acetaminophen toxicity), alfa-lipoic acid (for diabetic neuropathy) and some flavonoids (polyphenolic compounds present in dietary plants), such as micronized purified flavonoid fraction (diosmin and hesperidin) and oxerutins (for chronic venous insufficiency) as well as baicalein and catechins (for osteoarthritis) have found accepted clinical use. However, despite much enthusiasm in the 1980s and 1990s, many well-known agents such as antioxidant vitamins and also more recently developed compounds such as nitrones have not successfully passed the scrutiny of clinical trials for prevention and treatment of various diseases. This has given rise to a pessimistic view of antioxidant therapy, however, the evidence from human epidemiological studies about the beneficial effects of dietary antioxidants and preclinical in vitro and animal data are compelling. We have probably wasted too much time on agents like antioxidant vitamins instead of focusing on more disease specific, target-directed, highly bioavailable antioxidants. We here discuss possible reasons for the lack of success in some clinical trials and seek to provide some suggestions to be considered if antioxidant therapy is to succeed as an effective therapeutic strategy.

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Section: Nitronesmentioning

confidence: 99%

Clinical and pharmacological aspects of bath salt use: A review of the literature and case reports

Miotto¹,

Striebel²,

Cho

et al. 2013

Drug and Alcohol Dependence

121

View full text Add to dashboard Cite

show abstract

“…Based on these studies, a number of antioxidants were studied either to enhance intrinsic cochlear stress defenses or as exogenous antioxidants and have been successfully used to prevent AAT through systemic or local application in several animal models [20][21][22][23][24][25][26][27]. More importantly, postexposure treatment in animal models [21,24,27,28] provides a new possible use of the antioxidants to treat AAT in the clinic in the future.…”

Section: Introductionmentioning

confidence: 99%

“…More importantly, postexposure treatment in animal models [21,24,27,28] provides a new possible use of the antioxidants to treat AAT in the clinic in the future.…”

Section: Introductionmentioning

confidence: 99%

“…International Journal of Otolaryngology Protective mechanisms of 4-hydroxy phenyl N-tertbutylnitrone (4-OHPBN), a major metabolite of phenyl N-tert-butylnitrone (PBN), are still unclear although it has been successfully used in the treatment of AAT [21,31]. PBN is a spin trapping agent, and its phenyl ring reacts with hydroxyl radicals [32].…”

Section: Introductionmentioning

confidence: 99%

“…Biological functions of PBN may involve the reduction of oxidative stress and inflammation, as well as attenuation of glutamate excitotoxicity [33,34]. Although PBN was unable to reduce the auditory threshold shifts induced by noise alone in rats [35,36], the derivative, 4-OHPBN, alone or in combination with other antioxidants can effectively treat AAT in chinchilla, suggesting 4-OHPBN may have different biological functions compared to PBN [21]. A three-drug combination (NAC + ALCAR + 4-OHPBN) was significantly better than any single antioxidant treatment as reflected by hearing testing through auditory brainstem responses (ABRs) and outer hair cell (OHC) counts [21].…”

Section: Introductionmentioning

confidence: 99%

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Gene Therapy for Hearing Protection

Lee¹

2017

Korean J Otorhinolaryngol-Head Neck Surg

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Objective. Inhibition of inflammation and free radical formation in the cochlea may be involved in antioxidant treatment in acute acoustic trauma. Procedure. Chinchilla were exposed to 105 dB sound pressure level octave band noise for 6 hours. One group of chinchilla was treated with antioxidants after noise exposure. Auditory brainstem responses, outer hair cell counts, and immunohistochemical analyses of biomarkers in the cochlea were conducted. Results. The antioxidant treatment significantly reduced hearing threshold shifts, outer hair cell loss, numbers of CD45 + cells, as well as 4-hydroxy-2-nonenal and nitrotyrosine formation in the cochlea. Conclusion. Antioxidant treatment may provide protection to sensory cells by inhibiting formation of reactive oxygen and nitrogen products and migration of mononuclear phagocytes in the cochlea. The present study provides further evidence of effectiveness of antioxidant treatment in reducing permanent hearing loss.

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Synthetic Antioxidants

Durand¹

2013

Molecular Basis of Oxidative Stress

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Effectiveness of 4-hydroxy phenyl N-tert-butylnitrone (4-OHPBN) alone and in combination with other antioxidant drugs in the treatment of acute acoustic trauma in chinchilla

Cited by 62 publications

References 90 publications

Clinical and pharmacological aspects of bath salt use: A review of the literature and case reports

Clinical and pharmacological aspects of bath salt use: A review of the literature and case reports

Gene Therapy for Hearing Protection

Synthetic Antioxidants

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