Effectiveness of Acupoint Application in Patients with Pharyngeal Pain: Evidence from CHUNBO, A Prospective Real-World Study

Ma, Huiqiang; Wang, Yiming; Mei-zhu, Guo; Li, C.; Li, Rui; Gao, Rui

doi:10.1007/s11655-023-3699-8

Cited by 1 publication

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The formulation of our ointment is derived from the renowned traditional Chinese medicine doctor, Professor Yehuang Wang, from Jiangsu Province, China. The primary ingredients are traditional Chinese medicines, including Corydalis Rhizoma, Radix Sanguisorbae Carbonisata, Natrii Sulfas, Calcine Alunite, Plant soot, and Borneolum, with analgesic, hemostatic, swelling and other effects [19][20][21][22]. The aim of this experiment is to establish an experimental framework for optimizing the ointment formulation process, utilizing DSD, decision tree analysis, and Gaussian process optimization.…”

Section: Introductionmentioning

confidence: 99%

Refining the rheological characteristics of high drug loading ointment via SDS and machine learning

Qian,

Wang,

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

This paper presents an optimized preparation process for external ointment using the Definitive Screening Design (DSD) method. The ointment is a Traditional Chinese Medicine (TCM) formula developed by Professor WYH, a renowned TCM practitioner in Jiangsu Province, China, known for its proven clinical efficacy. In this study, a stepwise regression model was employed to analyze the relationship between key process factors (such as mixing speed and time) and rheological parameters. Machine learning techniques, including Monte Carlo simulation, decision tree analysis, and Gaussian process, were used for parameter optimization. Through rigorous experimentation and verification, we have successfully identified the optimal preparation process for WYH ointment. The optimized parameters included drug ratio of 24.5%, mixing time of 8 min, mixing speed of 1175 rpm, petroleum dosage of 79 g, liquid paraffin dosage of 6.7 g. The final ointment formulation was prepared using method B. This research not only contributes to the optimization of the WYH ointment preparation process but also provides valuable insights and practical guidance for designing the preparation processes of other TCM ointments. This advanced DSD method enhances the screening approach for identifying the best preparation process, thereby improving the scientific rigor and quality of TCM ointment preparation processes.

show abstract

Section: Introductionmentioning

confidence: 99%