Effectiveness of acupuncture combined mecobalamin in the treatment of elderly diabetic peripheral neuropathy

Abstract

Background: Although previous studies have reported the effectiveness of acupuncture combined mecobalamin (AM) in the treatment of elderly diabetic peripheral neuropathy (EDPN), no systematic study has assessed its effectiveness and safety. Thus, this study will evaluate the effectiveness and safety of AM for the treatment of patients with EDPN. Methods: Bibliographic electronic databases will be searched as follows: Cochrane Library, PUBMED, EMBASE, CINAHL, PsycINFO, WANGFANG, and China National Knowledge Infrastructure. All of them will be searched from each database initial to March 1, 2020 without language restrictions. All study selection, information extracted, and study quality evaluation will be performed by 2 independent authors. Any disagreements between 2 authors will be resolved by a third author via discussion. RevMan 5.3 software will be used for data pooling and meta-analysis performance if it is possible. Results: This study will provide synthesis of current evidence of AM for patients with EDPN through primary outcome of glycemic profile, and secondary of neuropathic pain intensity, plantar tactile sensitivity, sensory nerve conduction velocity and motor nerve conduction velocity, health-related quality of life, and adverse events. Conclusion: This study will provide helpful reference for the efficacy and safety of AM for the treatment of patients with EDPN to the clinicians and further studies. Study registration number: INPLASY202040094.

Effects of Infrared Combined with Methylcobalamin on the Vibratory Sensory Threshold and Nerve Conduction Velocity of the Lower Extremity in Patients with Diabetic Foot Treatment

“…Methylcobalamin is a commonly used drug for the treatment of diabetic foot. It is a methylated vitamin B 12 , which is widely distributed in peripheral nerves and can be transported to nerve cells to stimulate the synthesis of lecithin and axonal pulp proteins by transmethylation, repair myelin, and accelerate the regeneration of damaged axons, thus regulating nerve conduction speed and relieving patients' symptoms [ 9 ]. It has also been pointed out that mecobalamin is an endogenous B 12 , which can participate in the carbon unit cycle and has an important role in the homocysteine synthesis protein acid transmethylation reaction, and is extremely suitable for lower limb neuropathy [ 10 ].…”

"Effectiveness of Acupoint Massage for Improving Sensory Function of Peripheral Nerve in Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis"

“…However, there are few guidelines on improving nerve conduction. Some studies have proposed the use of neurotrophic agents such as mecobalamin and lipoic acid, but the clinical effect still need to be debated [12][13][14]. Therefore, some thought that treatment of DPN is limited [15] Nursing technique can assist clinical treatment to promote health, maintain health, and prevent disease.…”