Effectiveness of adjunctive antimicrobial photodynamic therapy in reducing peri -implant inflammatory response in individuals vaping electronic cigarettes: A randomized controlled clinical trial

Rifaiy, Mohammed Q Al; Qutub, Osama A.; Alasqah, Mohammed; Al-Sowygh, Zeyad H.; Mokeem, Sameer A; Alrahlah, Ali

doi:10.1016/j.pdpdt.2018.03.002

Cited by 33 publications

(103 citation statements)

References 33 publications

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“…A previous study showed that the outcomes of peri‐implantitis treated with mechanical debridement and PDT were similar between smokers and non‐smokers . A study suggested that adjunctive PDT achieved better outcomes than mechanical debridement alone in individuals using e‐cigarettes and conventional tobacco, but one study did not observe such effect . Those results suggest that smoking might not affect the outcomes of PVD, but additional studies are necessary to examine the factors that could affect the efficacy of PVD.…”

Section: Discussionsupporting

confidence: 87%

“…According to the literature, 66 participants with peri‐implantitis were given photodynamic therapy and conventional therapy respectively. Based on the available literature, the average decline in periodontal PD in the experimental and control groups after 6 weeks of treatment were estimated. With α = 0.05, β = 0.2, ratio of 1:1 and 20% loss to follow‐up, 132 participants were needed in total.…”

Section: Methodsmentioning

confidence: 95%

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Adjunctive photodynamic therapy improves the outcomes of peri‐implantitis: a randomized controlled trial

Wang

Zhang

et al. 2019

Australian Dental Journal

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Background: Photodynamic therapy (PDT) can be used for the management of peri-implantitis. This study aimed to explore the efficacy and safety of PDT for peri-implantitis in Chinese Han patients. Methods: This was a single-centre, open-label, randomized controlled trial of participants with peri-implantitis treated at the Beijing Chao-Yang Hospital, randomized 1:1 to PDT or no PDT. PDT was performed using toluidine blue (10 mg/ mL; 3 min) and a 635-nm laser (750 mW; 10 s/implant side; minimum of 60 mW/cm 2 ). The primary outcome was the decline in periodontal probing depth (PD) at 6 months. The secondary outcomes were peri-implant plaque index (PLI), sulcular bleeding index (SBI), and clinical attachment loss (CAL). Results: PD after treatment was smaller in the PDT group (n = 66) than in controls (n = 65) (all P < 0.001 vs. baseline). At 1 month, compared with controls, the PD in the PDT group was larger, while at 3-and 6-month, the PDs were smaller (all P < 0.001). CAL, PLI and SBI in the PDT group was better (P < 0.05 vs. controls). Conclusion: PDT combined with mechanical debridement significantly improves PD, PLI and SBI in participants with peri-implantitis. Importantly, PDT achieved a better CAL than mechanical debridement and cleaning.Abbreviations: AE = adverse event; CAL = clinical attachment loss; DB = distobuccal; PD = pocket depth; PDT = Photodynamic therapy; PLI = peri-implant plaque index; SBI = sulcular bleeding index.

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Section: Discussionsupporting

confidence: 87%

Section: Methodsmentioning

confidence: 95%

Adjunctive photodynamic therapy improves the outcomes of peri‐implantitis: a randomized controlled trial

Wang

Zhang

et al. 2019

Australian Dental Journal

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“…After excluding articles based on their titles and abstracts, 39 studies were left for full-text assessment. Following a discussion after full-text analysis, 18 studies were included for systematic review [9,10,12,13,16,17,19,20,23,24,26,[31][32][33][34][35][36]41]. The process of identi cation of the included studies from the initial yield is described in Fig.1.…”

Section: Resultsmentioning

confidence: 99%

“…PDT has also been reported to kill pathogenic microbes associated with the etiology of periodontal and peri-implant disease such as Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), Prevotella intermedia, and Porphyromonas gingivalis (P. gingivalis) [49]. A total of 7 articles included in this study were about PDT, three of which were about peri-implant mucositis [14,17,19] and four were about peri-implantitis [13,16,20,41]. The follow-up time of three literatures on peri-implant mucositis was only three months, probably because in ammation had improved signi cantly within three months after treatment, and no longer observation time was required.…”

Section: Discussionmentioning

confidence: 99%

“…Summarizing the risk of bias for each study, only six studies were considered at low risk of bias [17,20,23,33,34,36], seven were at unclear risk [10,14,16,19,31,35,41], and ve studies were considered at high risk of bias [9,13,24,26,32]. Results of the quality assessment of RCTs are listed in Table 2, following the recommendations [44].…”

Section: Quality Assessmentmentioning

confidence: 99%

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Adjunctive therapies for the nonsurgical treatment of peri-implant diseases: systemic review and meta-analysis

Xiao

Qin

2020

Preprint

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Background Peri-implant diseases are mainly caused by biofilms around the implant and may lead to implant failure. Non-surgical mechanical debridement with different adjunctive therapies has being applied in the treatment of peri-implant diseases. This systematic review aims to figure out whether one adjunctive therapy is superior to any other. Methods Two independent authors screened the literature via the MEDLINE, Cochrane Library and Science Direct. Only clinical randomized controlled trials (RCTs) that compared the efficacy of adjunctive therapies in the treatment of peri-implant diseases with non-surgical mechanical debridement (MD) were included in this review. The studies selected were published before June 2020. Comparisons of clinical outcomes were estimated using meta-analysis Results: A total of eighteen RCTs met the inclusion criteria, of which 13 articles were included in the meta-analysis. The following adjunctive interventions were compared in the included studies: modifying the prosthesis; air abrasive; photodynamic therapy; local antibiotics; systemic antibiotics; probiotics. Statistically significant difference was observed between MD with photodynamic therapy and MD alone at 3 months follow-up ( P < 0.01). There is no statistical difference between MD with chlorhexidine and MD alone in the treatment of peri-implant diseases at 3 months follow-up ( P = 0.84), so is MD with probiotics and MD alone ( P = 0.96), and so is systemic antibiotics and MD alone ( P = 0.47). Conclusion. MD adjunct with PDT is an effective treatment for peri-implant mucositis. However, there is still no effective non-surgical treatment for peri-implantitis.

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Adjunctive antimicrobial photodynamic therapy for treating periodontal and peri-implant diseases

Jervøe-Storm,

Bunke,

Worthington

et al. 2024

Cochrane Database of Systematic Reviews

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Effectiveness of adjunctive antimicrobial photodynamic therapy in reducing peri -implant inflammatory response in individuals vaping electronic cigarettes: A randomized controlled clinical trial

Cited by 33 publications

References 33 publications

Adjunctive photodynamic therapy improves the outcomes of peri‐implantitis: a randomized controlled trial

Adjunctive photodynamic therapy improves the outcomes of peri‐implantitis: a randomized controlled trial

Adjunctive therapies for the nonsurgical treatment of peri-implant diseases: systemic review and meta-analysis

Adjunctive antimicrobial photodynamic therapy for treating periodontal and peri-implant diseases

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